Protein Alignment Sk2 and SPHK1

DIOPT Version :9

• Sequence 1: NP_647762.3
• Gene: Sk2 / 326219
• FlyBaseID: FBgn0052484
• Length: 661
• Species: Drosophila melanogaster
• Sequence 2: NP_892010.2
• Gene: SPHK1 / 8877
• HGNCID: 11240
• Length: 470
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 155/569 - (27%)
• Similarity: 223/569 - (39%)
• Gaps: 152/569 - (26%)

  Fly    93 LAMSGACACSSGNPNSPAISASGDHHRPATTPSKCSTNSRDNIPSDGGDVSAFLYVFAYVLKKRS 157
            ||.....|.:..:..:||.:|.|....|.:.|......|.|.
Human    17 LAAPRGPAAAGNDAGAPAATAPGGEGEPHSRPCDARLGSTDK----------------------- 58

  Fly   158 LRSELHRERTVLTLRFRSFDTFEDNMREADRWYRSLRWQLHRTLEEIFVAPT-----VDERRRRV 217
                        .|:..:..|..........|.|..|.::        :.|.     |..|..||
Human    59 ------------ELKAGAAATGSAPTAPGTPWQREPRVEV--------MDPAGGPRGVLPRPCRV 103

  Fly   218 LVLLNPKSGSGDAREVFNMHVTPVLNEAEVPYDLYVTKHSNFAIEFLSTRCLDAWCCVVAVGGDG 282
            ||||||:.|.|.|.::|..||.|:|.|||:.:.|.:|:..|.|.|.:.:..|..|..:|.:.|||
Human   104 LVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDG 168

  Fly   283 LFHEIVNGLLQRQDWAHVLPHLALGIIPCGSGNGLARSIAHC--YNEPYFSKPVLGAALTVISGR 345
            |.||:||||::|.||...: ...|..:|.||||.||.|:.|.  |.:......:....|.:....
Human   169 LMHEVVNGLMERPDWETAI-QKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRL 232

  Fly   346 SSPMDVVRVQLQS-RSLYSFLSIGWGLISDVDIESERIRMLGYQRFTVWTLYRLVNLRTYNGRIS 409
            .|||:::.:...| ..|:|.||:.||.|:|||:|||:.|.||..|||:.|..||..||||.||::
Human   233 LSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLA 297

  Fly   410 YLLTDHEVSSTHSATGYAAQRRMQSSRSCNTHIDMLNGPAPIYHSSAEYLPQEFADVISLETSIN 474
            ||......|.|.::.....|                 ||.     .|..:|
Human   298 YLPVGRVGSKTPASPVVVQQ-----------------GPV-----DAHLVP-------------- 326

  Fly   475 QSFRSRCDSWLSGGSRRSFYYSISESIYHSLADESEFAGLAAASLENRQQNYGPASELPDLNEPL 539
                                                                        |.||:
Human   327 ------------------------------------------------------------LEEPV 331

  Fly   540 SEDQGW-LVEEGEFVMMHAVYQTHLGIDCHFAPKAQLNDGTIYLILIRAGISRPHLLSFLYNMSS 603
            ...  | :|.:.:||::.|:..:|||.:...||..:...|.::|..:|||:||..||.....|..
Human   332 PSH--WTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEK 394

  Fly   604 GTHLPESHDDHVKVLPVRAFRLEPYDNHGIITVDGERVEFGPLQAEVLP 652
            |.|: |....::..:||.||||||.|..|:..||||.:....:|.:|.|
Human   395 GRHM-EYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHP 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sk2	NP_647762.3	PLN02958	<213..639	CDD:215517	132/429 (31%)
		DAGK_cat	216..354	CDD:279163	55/139 (40%)
SPHK1	NP_892010.2	PLN02958	<97..431	CDD:215517	134/433 (31%)
		DAGK_cat	102..>207	CDD:279163	49/105 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146140
Domainoid	1	1.000	107	1.000	Domainoid score	I6506
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39748
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4295
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561206at33208
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	1	1.000	-	-		otm41245
orthoMCL	1	0.900	-	-		OOG6_101566
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R653
SonicParanoid	1	1.000	-	-		X918
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.690