DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sk2 and LCB5

DIOPT Version :9

Sequence 1:	NP_647762.3	Gene:	Sk2 / 326219	FlyBaseID:	FBgn0052484	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_013361.1	Gene:	LCB5 / 850964	SGDID:	S000004250	Length:	687	Species:	Saccharomyces cerevisiae

Alignment Length:	590	Identity:	134/590 - (22%)
Similarity:	243/590 - (41%)	Gaps:	105/590 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 SSGNPNSPAISASGDHHRPATTPSKCSTNS---------RDNIPSDGGDVSAFLYV-------FA 150
            ::.:|:||..|:.      :....||..:.         :.|..|.|.:.|:.|..       ..
Yeast   158 ANSSPSSPLSSSM------SNISEKCDLDELESSQKKERKGNSLSRGSNSSSSLLTSRSPFTKLV 216

  Fly   151 YVLKKRSLRSELHRERTVLTLRFRSFDTFEDNMREADRWYRSLRWQLHRTLEEIFVAPTVDERRR 215
            .|:..|..|.::..:|..|.:.::...:  .:::|.|           ..:|||......:.||.
Yeast   217 EVIFARPRRHDVVPKRVSLYIDYKPHSS--SHLKEED-----------DLVEEILKRSYKNTRRN 268

  Fly   216 R-VLVLLNPKSGSGDAREVFNMHVTPVLNEAEVPYDLYVTKHSNFAIEFLSTRCLDAWCCVVAVG 279
            : :.|::||..|.|.|:::|.....|:|..:....::..||:...|||......:|.:..:....
Yeast   269 KSIFVIINPFGGKGKAKKLFMTKAKPLLLASRCSIEVVYTKYPGHAIEIAREMDIDKYDTIACAS 333

  Fly   280 GDGLFHEIVNGLLQRQDWAHVLPHLALGIIPCGSGNGLARSIAHCYNEPYFSKPVLGAALTVISG 344
            |||:.||::|||.||.|......::|:..|||||||.::.| .|..|.|.:|      .|.:|..
Yeast   334 GDGIPHEVINGLYQRPDHVKAFNNIAITEIPCGSGNAMSVS-CHWTNNPSYS------TLCLIKS 391

  Fly   345 RSSPMDVVRVQLQS----RSLYSFLSIGWGLISDVDIESERIRMLGYQRFTVWTLYRLVNLRTYN 405
            ..:.:|::.....|    ....||||..:|||::.||.:|.||.:|..||.:...:.::..:.|.
Yeast   392 IETRIDLMCCSQPSYAREHPKLSFLSQTYGLIAETDINTEFIRWMGPARFELGVAFNIIQKKKYP 456

  Fly   406 GRISYLLTDHEVSSTHSATGYAAQRRMQSSRSCNTHIDML--NGPAPIYHSSAEYLPQ-----EF 463
            ..|   ...:...|.:....:..:.:.:.|.... ||.|.  |.....|:...||..:     |.
Yeast   457 CEI---YVKYAAKSKNELKNHYLEHKNKGSLEFQ-HITMNKDNEDCDNYNYENEYETENEDEDED 517

  Fly   464 ADVISLETSINQSFRSRCDSWLSGGSRRSFYYSISESIYHSLADESEFAGLAAASLENRQQNY-- 526
            ||....::.:                       ||..:..|.||:        ...|:.:..|
Yeast   518 ADADDEDSHL-----------------------ISRDLADSSADQ--------IKEEDFKIKYPL 551

  Fly   527 --GPASELPDLNEPLSEDQGWLVEEGEFVMMHAVYQTHLGIDCHFAPKAQLNDGTIYLILIRAGI 589
              |..|:...|:..:|.:.|         :.:.....::..|..|.|.|..:|||:.:::..|..
Yeast   552 DEGIPSDWERLDPNISNNLG---------IFYTGKMPYVAADTKFFPAALPSDGTMDMVITDART 607

  Fly   590 SRPHLLSFLYNMSSGTHLPESHDDHVKVLPVRAFRLEPYDNHGIITVDGERVEFGPLQAEVLPGI 654
            |...:...|..:..|:|:.:....|.|:|   |:::.|...:|:.:||||:....|||.|::|.:
Yeast   608 SLTRMAPILLGLDKGSHVLQPEVLHSKIL---AYKIIPKLGNGLFSVDGEKFPLEPLQVEIMPRL 669

  Fly   655 ARVMV 659
            .:.::
Yeast   670 CKTLL 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sk2	NP_647762.3	PLN02958	<213..639	CDD:215517	106/441 (24%)
Sk2	NP_647762.3	DAGK_cat	216..354	CDD:279163	42/138 (30%)
LCB5	NP_013361.1	LCB5	267..603	CDD:224513	92/386 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343285
Domainoid	1	1.000	90	1.000	Domainoid score	I1770
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I1088
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	1	1.000	-	-		mtm9231
orthoMCL	1	0.900	-	-		OOG6_101566
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R653
SonicParanoid	1	1.000	-	-		X918
TreeFam	1	0.960	-	-
	13	12.780