DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sk2 and SPHK1

DIOPT Version :9

Sequence 1:	NP_647762.3	Gene:	Sk2 / 326219	FlyBaseID:	FBgn0052484	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_193885.6	Gene:	SPHK1 / 828239	AraportID:	AT4G21540	Length:	485	Species:	Arabidopsis thaliana

Alignment Length:	516	Identity:	131/516 - (25%)
Similarity:	214/516 - (41%)	Gaps:	153/516 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 FDTFEDNMREADRWYRSLRW--QLHRTLEEIFVAPTVDERRRRVLVLLNPKSGSGDAREVFNMHV 238
            |:...|..|:.        |  :.|:.|..:       .|.:::||.:||..|...||::|...|
plant    93 FEPLSDESRKL--------WSDKFHQHLVSL-------GRPKKLLVFVNPFGGKKTARKIFQEEV 142

  Fly   239 TPVLNEAEVPYDLYVTKHSNFAIEFLSTRCLDAWCCVVAVGGDGLFHEIVNGLLQRQDWAHVLPH 303
            .|:..:|.:..::..||:...|.|.:.:..:..:..:|.|.|||:..|:|||||:|:||...: .
plant   143 KPLFEDANIQLEIQETKYQLHAKEIVRSMDVSKYDGIVCVSGDGILVEVVNGLLEREDWKTAI-K 206

  Fly   304 LALGIIPCGSGNGLARSIAHCYNEPYFSKPVLGAALTVISGRSSPMDVVRVQLQSRSLYSFLSIG 368
            |.:|::|.|||||:.:|:......|.   ....|.:::|.||:..:||..:...:...:|.|.:.
plant   207 LPIGMVPAGSGNGMIKSLLEPVGLPC---SATSATISIIRGRTRSLDVATISQGTTKFFSVLMLA 268

  Fly   369 WGLISDVDIESERIRMLGYQRFTVWTLYRLVNLRTYNGRISYLLTDHEVSSTHSATGYAAQRRMQ 433
            |||::|:|||||:.|.:|..||.::.|.|::.||.|:|||.::
plant   269 WGLVADIDIESEKFRWMGSARFDIYGLQRIICLRQYHGRILFV---------------------- 311

  Fly   434 SSRSCNTHIDMLNGPAPIYHSSAEYLPQEFADVISLETSINQSFRSRC--DSWLSGGSRRSFYYS 496
                          |||.:.|..:                    |:.|  |...||..:...|
plant   312 --------------PAPGFESYGQ--------------------RASCSIDKEPSGSDKTLVY-- 340

  Fly   497 ISESIYHSLADESEFAGLAAASLENRQQNYGPASELPDLNEPLSEDQGWLVEEGEF--VMMHAV- 558
                                         .||.|:|.:|:        |...:|.|  |.:|.|
plant   341 -----------------------------QGPDSKLENLD--------WREMKGPFVSVWLHNVP 368

  Fly   559 --YQTHLGIDCHFAPKAQLNDGTIYLILIRAGISRPHLLSFLYNMSSGTHLPESHDDHVKVLPVR 621
              .:..|.     ||.|:.:||.:.||::: ...:..|||.:..:|.|||:...:..::|   |:
plant   369 WGAENTLA-----APDAKFSDGFLDLIVMK-DCPKLALLSLMTKLSDGTHVQSPYASYLK---VK 424

  Fly   622 AFRLEP------YDNHGIITVDGE---------------RVEFGPLQAEVLPGIARVMVPK 661
            ||.|||      .|..|||..|||               .:.:..||..|..|:|.:..|:
plant   425 AFVLEPGARIDEPDKEGIIDSDGEVLARGRKSYKCDQKALMSYDKLQISVDQGLATLFSPE 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sk2	NP_647762.3	PLN02958	<213..639	CDD:215517	117/438 (27%)
Sk2	NP_647762.3	DAGK_cat	216..354	CDD:279163	45/137 (33%)
SPHK1	NP_193885.6	PLN02958	8..485	CDD:215517	130/514 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	108	1.000	Domainoid score	I2150
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I1316
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681139at2759
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	1	1.000	-	-		mtm1039
orthoMCL	1	0.900	-	-		OOG6_101566
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X918
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830