DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sk2 and CERK

DIOPT Version :9

Sequence 1:NP_647762.3 Gene:Sk2 / 326219 FlyBaseID:FBgn0052484 Length:661 Species:Drosophila melanogaster
Sequence 2:NP_073603.2 Gene:CERK / 64781 HGNCID:19256 Length:537 Species:Homo sapiens


Alignment Length:485 Identity:121/485 - (24%)
Similarity:187/485 - (38%) Gaps:147/485 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   189 WYRSLRWQLHRTLEEIFVAPTVDERRRRVLVLLNPKSGSGDAREVFNMHVTPVLNEAEVPYDLYV 253
            |.::||..|.:          :..|.:.:||.:||..|.|..:.::...|.|:...|.:..|:.|
Human   115 WLQTLREMLEK----------LTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIV 169

  Fly   254 TKHSNFAIEFLSTRCLDAWCCVVAVGGDGLFHEIVNGLLQRQ------DWAH-----VLPHLALG 307
            |:|:|.|.|.|....:|.:..:|.|||||:|.|:::||:.|.      |..|     |...|.:|
Human   170 TEHANQAKETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIG 234

  Fly   308 IIPCGSGNGLARSIAHCYNEPYFSKPVLG------AALTVISGRSSPMDVVRVQLQSRSL-YSFL 365
            |||.||.:.:      ||:       .:|      :||.::.|.|..|||..|...|..| ||..
Human   235 IIPAGSTDCV------CYS-------TVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVS 286

  Fly   366 SIGWGLISDVDIESERIRMLGYQRFTVWTLYRLVNLRTYNGRISYLLTDHEVSSTHSATGYAAQR 430
            .:|:|...|:..:||:.|.||..|:....|...::...|.|.:|:|...|.|.|...        
Human   287 LLGYGFYGDIIKDSEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRD-------- 343

  Fly   431 RMQSSRSCNTHIDMLNGPAPIYHSSAEYLPQEFADVISLETSINQSFRSRCDSWLSGGSRRSFYY 495
            |......|.           :...|.:.|.:|                          .:::.| 
Human   344 RKPCRAGCF-----------VCRQSKQQLEEE--------------------------QKKALY- 370

  Fly   496 SISESIYHSLADESEFAGLAAASLENRQQNYGPASELPDLNEPLSEDQGWLVEEGEFVMMHAVYQ 560
                             ||.||.               |:.|       |.|..|:|:.::|   
Human   371 -----------------GLEAAE---------------DVEE-------WQVVCGKFLAINA--- 393

  Fly   561 THLGIDCH-----FAPKAQLNDGTIYLILIRAGISRPHLLSFLYNMSSGTHLPESHD-DHVKVLP 619
            |::...|.     .:|.|.|.||:..|||||. .||.:.|.||..   .|:..:..| ..|:|..
Human   394 TNMSCACRRSPRGLSPAAHLGDGSSDLILIRK-CSRFNFLRFLIR---HTNQQDQFDFTFVEVYR 454

  Fly   620 VRAFR-----LEPYDNHGIITVDGERVEFG 644
            |:.|:     :|..|:.   ..:|.:..||
Human   455 VKKFQFTSKHMEDEDSD---LKEGGKKRFG 481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sk2NP_647762.3 PLN02958 <213..639 CDD:215517 114/454 (25%)
DAGK_cat 216..354 CDD:279163 49/154 (32%)
CERKNP_073603.2 Required for binding to sulfatide and phosphoinositides. /evidence=ECO:0000269|PubMed:19168031 1..125 4/9 (44%)
Essential for enzyme activity. /evidence=ECO:0000269|PubMed:16269826 1..115 121/485 (25%)
PLN02204 55..528 CDD:215126 121/485 (25%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:Q9NYA1 195..198 2/2 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146138
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1597
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D681139at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.750

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