DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sk2 and SPHK2

DIOPT Version :9

Sequence 1:	NP_647762.3	Gene:	Sk2 / 326219	FlyBaseID:	FBgn0052484	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	XP_016882497.1	Gene:	SPHK2 / 56848	HGNCID:	18859	Length:	716	Species:	Homo sapiens

Alignment Length:	582	Identity:	198/582 - (34%)
Similarity:	284/582 - (48%)	Gaps:	74/582 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 PATTPSKCSTNSRDNIPSDGGDVSAFLYVFAYVLKKRSLRSELHRERTVLTLRFRSFDTFEDNMR 184
            |....|.|.| .|...|||.   :|:..::.|...:|..     |.|...|.|.....|:|:|..
Human   155 PLAEVSGCCT-LRSRSPSDS---AAYFCIYTYPRGRRGA-----RRRATRTFRADGAATYEENRA 210

  Fly   185 EADRWYRSLRWQLHRTLE---EIFVAPTVDERRRRVLVLLNPKSGSGDAREVFNMHVTPVLNEAE 246
            ||.||..:|...| |.|.   :..:.|.:..|..|:|:|:||..|.|.|.:....||.|:::||.
Human   211 EAQRWATALTCLL-RGLPLPGDGEITPDLLPRPPRLLLLVNPFGGRGLAWQWCKNHVLPMISEAG 274

  Fly   247 VPYDLYVTKHSNFAIEFLSTRCLDAWCCVVAVGGDGLFHEIVNGLLQRQDWAHVLPHLALGIIPC 311
            :.::|..|:..|.|.|.:....|..|..:|.|.||||.||::||||.|.||...: .:.:||:||
Human   275 LSFNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVLNGLLDRPDWEEAV-KMPVGILPC 338

  Fly   312 GSGNGLARSIAHCYNEPYFSKPVLG------AALTVISGRSSPMDVVRVQLQSRS-LYSFLSIGW 369
            ||||.||.::    |:....:|.||      .:|.:..|...|:|::.|.|.|.| .:||||:.|
Human   339 GSGNALAGAV----NQHGGFEPALGLDLLLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAW 399

  Fly   370 GLISDVDIESERIRMLGYQRFTVWTLYRLVNLRTYNGRISYLLTDHEVSSTHSATGYAAQRRMQS 434
            |.:|||||:|||.|.||..|||:.|:..|..|.||.||:|||....|.:|...|         .|
Human   400 GFVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLSYLPATVEPASPTPA---------HS 455

  Fly   435 SRSCNTHIDMLNGPA------PIYHSSAEY---LPQ---------EFADVISLE---TSINQSFR 478
            .....:.:.:...||      |::.|.::.   |||         |...::||.   ..:...:.
Human   456 LPRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWG 520

  Fly   479 SRCDSWLSGGSRRSFYYSISESIYHSLADES-----EFAGLAAASLENR--QQNYGPASE-LPDL 535
            ...|:.||.....|......::..||...|.     ..:||...:.:.|  ....||... ||.|
Human   521 GAGDAPLSPDPLLSSPPGSPKAALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPL 585

  Fly   536 NEPLSEDQGWLVEEGEFVMMHAVYQTHLGIDCHFAPKAQLNDGTIYLILIRAGISRPHLLSFLYN 600
            ..||..|  |:..||:||:|.|:..:|||.|...||.|:.:||.::|..:|:||||..||.....
Human   586 GTPLPPD--WVTLEGDFVLMLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLA 648

  Fly   601 MSSGTHL----PESHDDHVKVLPVRAFRLEPYDNHGIITVDGERVEFGPLQAEVLPGIARVM 658
            |..|:|.    |:     :.....|||||||....|::|||||:||:|||||::.|||..::
Human   649 MERGSHFSLGCPQ-----LGYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLL 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sk2	NP_647762.3	PLN02958	<213..639	CDD:215517	159/465 (34%)
Sk2	NP_647762.3	DAGK_cat	216..354	CDD:279163	53/143 (37%)
SPHK2	XP_016882497.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146142
Domainoid	1	1.000	177	1.000	Domainoid score	I3605
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47523
OrthoDB	1	1.010	-	-		D561206at33208
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101566
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R653
SonicParanoid	1	1.000	-	-		X918
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800