DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sk2 and sphk1

DIOPT Version :9

Sequence 1:	NP_647762.3	Gene:	Sk2 / 326219	FlyBaseID:	FBgn0052484	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_001016918.1	Gene:	sphk1 / 549672	XenbaseID:	XB-GENE-1015643	Length:	509	Species:	Xenopus tropicalis

Alignment Length:	536	Identity:	170/536 - (31%)
Similarity:	239/536 - (44%)	Gaps:	111/536 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 DGGDVSAFLYVFAYVLKKRSLRSELHRERTVLTLRFRSFDTFEDNMREADRWYRSLRWQLHRTLE 202
            |..::..:|......|:..:|...::|:|...|.|.......|.|...|..|...: |::   .|
Frog    71 DPTELGGYLTAAFCPLRGEALGKTIYRQRVSRTFRIEVSRDKEHNFNVAKTWANRI-WEM---AE 131

  Fly   203 EIFVAPTVDERRRRVLVLLNPKSGSGDAREVFNMHVTPVLNEAEVPYDLYVTKHSNFAIEFLSTR 267
            |.....::....||.||||||.:|:|.|...|..||.|.|.||...:.|..|:....|.|.:...
Frog   132 EQGPPSSILPPSRRFLVLLNPFAGTGKASGHFQTHVIPTLTEANATFTLLETERPKQAQELVRDE 196

  Fly   268 CLDAWCCVVAVGGDGLFHEIVNGLLQRQDWAHVLPHLALGIIPCGSGNGLARSIAHCYNEPYFS- 331
            .|..|..:|.:.||||..|:||||::|.|||..:.. .|.::|.||||.||.|::      |:|
Frog   197 DLSGWDAIVVMAGDGLLFEVVNGLMERPDWACAIKK-PLAVLPGGSGNALAASVS------YYSG 254

  Fly   332 -KPVLGAAL------TVISGRSSPMDVVRVQLQS-RSLYSFLSIGWGLISDVDIESERIRMLGYQ 388
             |...|..|      .:..|:..|:|:|.:...| |.::||||..|||||||||||||.|.:|..
Frog   255 HKQASGTKLLNNCTFILCKGQPVPLDLVSLTTSSGRRIFSFLSFAWGLISDVDIESERYRFMGSA 319

  Fly   389 RFTVWTLYRLVNLRTYNGRISYLLTDHEVSSTHSATGYAAQRRMQSSRSCNTHIDMLNGPAPIYH 453
            ||:..|..||..||||.||:|||                                    ||   .
Frog   320 RFSFGTFVRLTALRTYRGRLSYL------------------------------------PA---R 345

  Fly   454 SSAEYLPQEFADVISLETSINQSFRSRCDSWLSGGSRRSFYYSISESIYHSLADESEFAGLAAAS 518
            :|.:..|:                                    |:|..|:|          .:|
Frog   346 TSPDSTPE------------------------------------SDSHRHNL----------NSS 364

  Fly   519 LENRQQNYGPASELPDLNEPLSEDQGW-LVEEGEFVMMHAVYQTHLGIDCHFAPKAQL-NDGTIY 581
            .:....|....|.|..||||:...  | .|.|.:||::..:||:|||.|...||..|. .:|.:.
Frog   365 TDTVNPNVLEDSLLVPLNEPVPPH--WTTVTEDQFVLVLLLYQSHLGADLFTAPMVQSPGEGVMQ 427

  Fly   582 LILIRAGISRPHLLSFLYNMSSGTHLPESHDDHVKVLPVRAFRLEPYDNHGIITVDGERVEFGPL 646
            |....:.|||..||.....|..|:|:.|| ..|:..:||.||||||.:|.||:|||||.:....|
Frog   428 LFYATSRISRASLLKLFLGMEKGSHMGES-IPHITNVPVTAFRLEPLENVGIMTVDGESIPCCSL 491

  Fly   647 QAEVLPGIARVM-VPK 661
            |.::..|:.|:: :|:
Frog   492 QGQIHKGLGRIISIPQ 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sk2	NP_647762.3	PLN02958	<213..639	CDD:215517	148/436 (34%)
Sk2	NP_647762.3	DAGK_cat	216..354	CDD:279163	55/145 (38%)
sphk1	NP_001016918.1	PLN02958	100..484	CDD:215517	157/482 (33%)
sphk1	NP_001016918.1	DAGK_cat	145..284	CDD:279163	55/145 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3683
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39748
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2769
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561206at33208
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	1	1.000	-	-		mtm9501
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X918
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.070