DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sk2 and SPAC4A8.07c

DIOPT Version :9

Sequence 1:	NP_647762.3	Gene:	Sk2 / 326219	FlyBaseID:	FBgn0052484	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_593818.1	Gene:	SPAC4A8.07c / 2543328	PomBaseID:	SPAC4A8.07c	Length:	458	Species:	Schizosaccharomyces pombe

Alignment Length:	455	Identity:	106/455 - (23%)
Similarity:	178/455 - (39%)	Gaps:	114/455 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 ERRRRVLVLLNPKSGSGDAREVFNMHVTPVLNEAEVPYDLYVTKHSNFAIEFLSTRCLDAWCCVV 276
            :|.||.:|.:||..|.|.|:.::.....||.:.|....::.:|:..:.|........:.::..::
pombe   103 KRSRRFIVFINPHGGKGKAKHIWESEAEPVFSSAHSICEVVLTRRKDHAKSIAKNLDVGSYDGIL 167

  Fly   277 AVGGDGLFHEIVNGLLQRQDWAHVLPHLALGIIPCGSGNGLARSIAHCYNEPYFSKPVLGAALTV 341
            :|||||||||::|||.:|.|:.... .|.:.:||.||||      |..||.....||.| .||.:
pombe   168 SVGGDGLFHEVINGLGERDDYLEAF-KLPVCMIPGGSGN------AFSYNATGQLKPAL-TALEI 224

  Fly   342 ISGRSSPMDVVRVQLQSRSLYSFLSIGWGLISDVDIESERIRMLGYQRFTVWTLYRLVNLRTYNG 406
            :.||.:..|::..:.:.:..||||:..:|:|:|.||.:|..|.:|..|
pombe   225 LKGRPTSFDLMTFEQKGKKAYSFLTANYGIIADCDIGTENWRFMGENR----------------- 272

  Fly   407 RISYLLTDHEVSSTHSATGYAAQRRMQSSRSCNTHIDMLNGPAPIYHSSAEYLPQEFADVISLET 471
              :||             |:..:...:....|:  |:|                    ||:|
pombe   273 --AYL-------------GFFLRLFQKPDWKCS--IEM--------------------DVVS--- 297

  Fly   472 SINQSFRSRCDSWLSGGSRRSFYYSISESIYHSLADESEFAGLAAASLENRQQNYGPASELPDLN 536
                                              :|.:|.     ..:..:.:|..|.||..|.:
pombe   298 ----------------------------------SDRTEI-----KHMYEKSKNLAPMSESSDSD 323

  Fly   537 EPLS---EDQGWLVEEGEFVMMHAVYQTHLGIDCHFAPKAQLNDGTIYLILIRAGISRPHLLSFL 598
            :.:|   |......|..:..:..|....::..|....|.|..:||.|.::::.:...|..|||..
pombe   324 KTVSTSPESHLLTFEINDLSIFCAGLLPYIAPDAKMFPAASNDDGLIDVVIVYSKQFRKSLLSMF 388

  Fly   599 YNMSSGTHLPESHDDHVKVLPVRAFRLEPYDNHG---IITVDGERVEFGPLQAEVLPGIARVMVP 660
            ..:.:|......|.::.|   ||:||..|. |.|   ...:|||.....|.:..|.|.:...:.|
pombe   389 TQLDNGGFYYSKHLNYYK---VRSFRFTPV-NTGKRHYFALDGESYPLEPFECRVAPKLGTTLSP 449

Fly 661 660
pombe 450 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sk2	NP_647762.3	PLN02958	<213..639	CDD:215517	100/431 (23%)
Sk2	NP_647762.3	DAGK_cat	216..354	CDD:279163	44/137 (32%)
SPAC4A8.07c	NP_593818.1	LCB5	104..442	CDD:224513	104/445 (23%)
SPAC4A8.07c	NP_593818.1	DAGK_cat	107..236	CDD:279163	44/136 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	74	1.000	Domainoid score	I2510
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I1327
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	1	1.000	-	-		otm47232
orthoMCL	1	0.900	-	-		OOG6_101566
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R653
SonicParanoid	1	1.000	-	-		X918
TreeFam	1	0.960	-	-
	12	11.850