DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sk2 and SPHK2

DIOPT Version :9

Sequence 1:	NP_647762.3	Gene:	Sk2 / 326219	FlyBaseID:	FBgn0052484	Length:	661	Species:	Drosophila melanogaster
Sequence 2:	NP_001190787.1	Gene:	SPHK2 / 10723114	AraportID:	AT4G21534	Length:	481	Species:	Arabidopsis thaliana

Alignment Length:	478	Identity:	126/478 - (26%)
Similarity:	200/478 - (41%)	Gaps:	138/478 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 RRRRVLVLLNPKSGSGDAREVFNMHVTPVLNEAEVPYDLYVTKHSNFAIEFLSTRCLDAWCCVVA 277
            |.:|:||.:||..|...|||:|...|.|:..:|:|..::..||:...|.||:.:..:..:..:|.
plant   112 RPKRLLVFVNPFGGKKSAREIFVKEVKPLFEDADVQLEIQETKYQLHAKEFVKSMDVSKYDGIVC 176

  Fly   278 VGGDGLFHEIVNGLLQRQDWAHVLPHLALGIIPCGSGNGLARSIAH------CYNEPYFSKPVLG 336
            |.|||:..|:|||||:|.||.:.| .|.:|::|.|:|||:.:|:..      |.|         .
plant   177 VSGDGILVEVVNGLLERADWRNAL-KLPIGMVPAGTGNGMIKSLLDTVGLRCCAN---------S 231

  Fly   337 AALTVISGRSSPMDVVRVQLQSRSLYSFLSIGWGLISDVDIESERIRMLGYQRFTVWTLYRLVNL 401
            |.:::|.|....:||..:...:...:|.|.:.||||:|:|||||:.|.:|..|...:.|.|::.|
plant   232 ATISIIRGHKRSVDVATIAQGNTKFFSVLMLAWGLIADIDIESEKFRWMGSARIDFYALQRIICL 296

  Fly   402 RTYNGRISYLLTDHEVSSTHSATGYAAQRRMQSSRSCNTHIDMLNGPAPIYHSSAEYLPQEFADV 466
            |.|||||.:|                                    |||.:....:
plant   297 RRYNGRILFL------------------------------------PAPGFEGYGQ--------- 316

  Fly   467 ISLETSINQSFRSRCDSWLSGGSRRSFYYSISESIYHSLADESEFAGLAAASLENRQQNY-GPAS 530
                                         ..|.|:|..            ..:.:::..| ||.:
plant   317 -----------------------------PASCSLYQE------------PHVSDKEVGYQGPET 340

  Fly   531 ELPDLNEPLSEDQGWLVEEGEFVMMHAVYQTHLGIDCHF-APKAQLNDGTIYLILIRAGISRPHL 594
            :..||.        |...:|.||.:. ::....|.:... ||.|:.:||.:.||::: ...:..|
plant   341 KFEDLE--------WREMKGPFVTIW-LHNVPWGSENTLTAPAAKFSDGYLDLIVLK-NCPKLVL 395

  Fly   595 LSFLYNMSSGTHLPESHDDHVKVLPVRAFRLEP------YDNHGIITVDGE-------------- 639
            ||.:...|||||:...:..::|   |:||.|||      .|..|||..|||
plant   396 LSLMRQTSSGTHVESPYIVYIK---VKAFVLEPGALVDEPDKEGIIDSDGEVLARGKRTYKCDQK 457

  Fly   640 -RVEFGPLQAEVLPGIARVMVPK 661
             .:.:..||..|..|:|.:..|:
plant   458 ALMSYDKLQVTVDQGLATLFSPE 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sk2	NP_647762.3	PLN02958	<213..639	CDD:215517	118/439 (27%)
Sk2	NP_647762.3	DAGK_cat	216..354	CDD:279163	49/143 (34%)
SPHK2	NP_001190787.1	PLN02958	1..480	CDD:215517	125/476 (26%)
SPHK2	NP_001190787.1	DAGK_cat	115..249	CDD:279163	49/143 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	108	1.000	Domainoid score	I2150
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I1316
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681139at2759
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	1	1.000	-	-		mtm1039
orthoMCL	1	0.900	-	-		OOG6_101566
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X918
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830