Protein Alignment Sk2 and sphk1

DIOPT Version :10

• Sequence 1: NP_647762.3
• Gene: Sk2 / 326219
• FlyBaseID: FBgn0052484
• Length: 661
• Species: Drosophila melanogaster
• Sequence 2: XP_073800142.1
• Gene: sphk1 / 100331840
• ZFINID: ZDB-GENE-130312-3
• Length: 493
• Species: Danio rerio
• Alignment Length: 644
• Identity: 186/644 - (28%)
• Similarity: 273/644 - (42%)
• Gaps: 196/644 - (30%)

  Fly    44 GSHVFRVRLDATGFTLQR-ESPGGSIVKEQHVRISDIVGARCMRPKKSRRLAMSGACACSSGNPN 107
            |...:.:.|..:..|:|| .||.......:|:.:.|.:|:|..|.::..|.|.
Zfish    16 GRLTYALSLSDSCLTVQRVSSPPSQTPAPEHLDLRDCLGSRAHRGEREDRDAY------------ 68

  Fly   108 SPAISASGDHHRPATTPSKCSTNSRDNIPSDGGDVSAFLYVFAYVLKKRSLRSELHRERTVLTLR 172
                                                 :|.|:.|..::|.:.....|:|.  ..|
Zfish    69 -------------------------------------YLCVYFYPYRRRWMAWGPVRQRD--ERR 94

  Fly   173 FRSFDTFEDN---------------MREADRWYRSLRWQLHRTLEEIFVAPTVDERRRR--VLVL 220
            ||.....:||               :|||:||.|::|.:...|...:|     .|.||.  |:||
Zfish    95 FRLVLNSDDNNDDEQEEEDEEEDAKLREAERWARAIRNRPGNTRGVLF-----SEVRRACGVMVL 154

  Fly   221 LNPKSGSGDAREVFNMHVTPVLNEAEVPYDLYVTKHSNFAIEFLSTRCLDAWCCVVAVGGDGLFH 285
            :||:||.|.|...:|.||..:|.||::|:.|.:|:..|.|.:.:.:..|..|..::.:.||||..
Zfish   155 VNPQSGRGQAMAQYNGHVQRMLTEADIPHTLVITERQNHARDLVRSTDLSQWDALIILSGDGLLF 219

  Fly   286 EIVNGLLQRQDWAHVLPHLALGIIPCGSGNGLARSIAHCYNEPYFSKPVLGAAL------TVISG 344
            |:||||::|.||...: ...|||:|.||||.||.|:.| |..   :.||.|..|      .:..|
Zfish   220 EVVNGLMERPDWEKAI-QTPLGILPGGSGNALAASVHH-YTR---ASPVWGEDLLTSCGFLLCKG 279

  Fly   345 RSSPMDVVRVQLQSRS-LYSFLSIGWGLISDVDIESERIRMLGYQRFTVWTLYRLVNLRTYNGRI 408
            ..|.:|::.|||.|.: |:||||:.||.::|||||||..|.:|..||.:.||.||.:||.|.|::
Zfish   280 LVSGLDLISVQLSSGARLFSFLSLAWGFVADVDIESETFRQIGALRFILGTLVRLASLRIYQGKL 344

  Fly   409 SYL---LTDHEVSSTHSATGYAAQRRMQSSRSCNTHIDMLNGPAPIYHSSAEYLPQEFADVISLE 470
            :||   .|| .||||             .....|.|:
Zfish   345 AYLPAGETD-SVSST-------------GENLLNDHL---------------------------- 367

  Fly   471 TSINQSFRSRCDSWLSGGSRRSFYYSISESIYHSLADESEFAGLAAASLENRQQNYGPASELPDL 535
                                                                         :...
Zfish   368 -------------------------------------------------------------MAPF 371

  Fly   536 NEPLSEDQGW-LVEEGEFVMMHAVYQTHLGIDCHFAPKAQLNDGTIYLILIRAGISRPHLLSFLY 599
            .:|:  .|.| ||||.|||::.|::|:||..|...||.|:.:||.|:|..:.||:||..||....
Zfish   372 GQPV--PQNWTLVEEREFVLVLAMFQSHLSEDLMAAPGARADDGIIHLFYLTAGVSRATLLRLFR 434

  Fly   600 NMSSGTHLPESHDDHVKVLPVRAFRLEPYDNHGIITVDGERVEFGPLQAEVLPGIARVM 658
            .|.||||| :....|:..:..:|.||||....|::|||||||.:||:||:|....||::
Zfish   435 AMQSGTHL-DCGCAHLVYVRAQAIRLEPLSADGVLTVDGERVHYGPVQAQVHRAAARII 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sk2	NP_647762.3	PLN02958	<213..639	CDD:215517	140/438 (32%)
sphk1	XP_073800142.1	None