Protein Alignment Sk2 and sphk2

DIOPT Version :10

• Sequence 1: NP_647762.3
• Gene: Sk2 / 326219
• FlyBaseID: FBgn0052484
• Length: 661
• Species: Drosophila melanogaster
• Sequence 2: XP_068070266.2
• Gene: sphk2 / 100150090
• ZFINID: ZDB-GENE-100922-225
• Length: 865
• Species: Danio rerio
• Alignment Length: 923
• Identity: 236/923 - (25%)
• Similarity: 329/923 - (35%)
• Gaps: 364/923 - (39%)

  Fly     2 SESLDKTTSPSSASSRATPPGTQDADEGHDVSDTFYTSQRKKGSHVFRVRLDATGFTLQRESPGG 66
            |.|.....||...|..::|..|.                       :.:.|..|...:||.||
Zfish    32 SNSNSCPNSPGGVSLPSSPASTN-----------------------YALTLTPTHIHVQRLSP-- 71

  Fly    67 SIVKEQHVRISDIVGARCMRPKKSRRLAMSGA----CACSSGNPNSPAISASGDHHRPATTPSKC 127
                               |..|..||.:..|    |:|    |.|||
Zfish    72 -------------------RAGKQSRLLLPMAELTGCSC----PRSPA----------------- 96

  Fly   128 STNSRDNIPSDGGDVSAFLYVFAYVLKKRSLRSELHRERTVLTLRFRSFDTFEDNMREADRWYRS 192
                           ...|.::.|...:|  |..:.|.|.|     |::  ..::..||::|..:
Zfish    97 ---------------PPLLVLYWYPPGRR--RKGVSRHRQV-----RAY--LAESRAEAEKWNAA 137

  Fly   193 LRWQLHRTLEEIFVAPTVD------ERRRRVLVLLNPKSGSGDAREVFNMHVTPVLNEAEVPYDL 251
            :: .|.|.::   |:.|.:      .|.||:|:|:||.||.|.|.:....|:.|::.||.:.|:|
Zfish   138 IQ-SLLRGMD---VSSTTEFCKSMLPRPRRLLLLVNPFSGRGQAMQWCQTHILPMIREANISYNL 198

  Fly   252 YVTKHSNFAIEFLSTRCLDAWCCVVAVGGDGLFHEIVNGLLQRQDWAHVLPHLALGIIPCGSGNG 316
            ..|:..|.|.|.:....|..|..:|.|.||||.||::|||::|.||...: ...:||:||||||.
Zfish   199 IQTERQNHARELIREISLPEWDGIVIVSGDGLLHEVINGLMERPDWEQAI-KTPVGILPCGSGNA 262

  Fly   317 LARSIAH------CYNEPYFSKPVLGAALTVISGRSSPMDVVRVQLQ----------------SR 359
            ||.||.|      |..||.    :|.....:..|...|:|:|.|...                .|
Zfish   263 LAGSINHHAGYDMCLREPL----LLNCCFLLCRGGVKPLDLVSVTTSPCASSSTSNQNGHPPAPR 323

  Fly   360 SLYSFLSIGWGLISDVDIESERIRMLGYQRFTVWTLYRLVNLRTYNGRISYL------------- 411
            .|:||||:.||.:|||||||||.|.||..|||:.||.||.:||:|.||:|||
Zfish   324 RLFSFLSVAWGFVSDVDIESERYRGLGSARFTLGTLVRLASLRSYKGRLSYLPPAVVNPSPDATP 388

  Fly   412 ----------LTD-------HEVSSTHSATGYAAQR----------------RMQSSRSCNTHID 443
                      :|:       ..:..|.|..|.:.||                |.:..|......|
Zfish   389 QPPRRPLSRSITEGLEGFCRTPIHRTCSDMGLSEQRSLRKDDGERERERERERQERERERERRRD 453

  Fly   444 MLNGPAPIYHSS-AEYLPQEFADVISLE----TSINQSFRSRCDSWL----------SGGSR--- 490
            ...|...:..|| ||...:|......:|    ||...:.|..||:..          ||.|:
Zfish   454 RARGVGVVRASSLAEDREREVEAEEKMEEMSGTSSESTERDECDNIAKNNGNEEENNSGESKIDG 518

  Fly   491 ------RSF------------YYSISESIYHSL--------------------ADESEFAGLAAA 517
                  |:.            |.:....:.|:|                    ||..:...|||.
Zfish   519 QELTNARNLSDTNEVNDCDGSYQTTPPELQHALRKNSAPSSQIINAFFSQPIGADTDQDLELAAY 583

  Fly   518 SLEN------------------------------RQ------------QNYGPASELP------- 533
            ..|:                              ||            ||..|:...|
Zfish   584 GKEDEDINGTYFQKEAYSLDKSRERALTISSSPFRQSPFKAFKPKTLDQNQNPSRPRPLSLLHQS 648

  Fly   534 -------------------------------------------------------DLNEP----- 538
                                                                   ||.||
Zfish   649 HSNSLPPKFPSLSPTPPSSPSCASPHSSYLAPRPNTPSSSSPSPSIHSPTPSFNFDLAEPAGPLK 713

  Fly   539 ----------LSED------------QGWLVEEGEFVMMHAVYQTHLGIDCHFAPKAQLNDGTIY 581
                      |.||            :.|:..||:||::.|:||:|||.|...||:|:.:||.|:
Zfish   714 NRPHMTSSINLPEDDLLPPLDQPLPTRDWVTIEGDFVLVLAIYQSHLGADLLAAPQARFDDGLIH 778

  Fly   582 LILIRAGISRPHLLSFLYNMSSGTHLPESHDDHVKVLPVRAFRLEPYDNHGIITVDGERVEFGPL 646
            |..:||||||..||.....|..|.||..| ..:|..:..|||||:|....|.:|||||.|.:|||
Zfish   779 LTFVRAGISRATLLRLFLAMERGAHLSLS-SPYVSHVSARAFRLQPLSPRGTLTVDGELVPYGPL 842

  Fly   647 QAEVLPGIARVMV 659
            ||:|.|.:||::|
Zfish   843 QAQVHPSMARLIV 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sk2	NP_647762.3	PLN02958	<213..639	CDD:215517	184/680 (27%)
sphk2	XP_068070266.2	None