Protein Alignment Sk2 and sphk2

DIOPT Version :9

• Sequence 1: NP_647762.3
• Gene: Sk2 / 326219
• FlyBaseID: FBgn0052484
• Length: 661
• Species: Drosophila melanogaster
• Sequence 2: XP_021322621.1
• Gene: sphk2 / 100150090
• ZFINID: ZDB-GENE-100922-225
• Length: 869
• Species: Danio rerio
• Alignment Length: 927
• Identity: 236/927 - (25%)
• Similarity: 329/927 - (35%)
• Gaps: 368/927 - (39%)

  Fly     2 SESLDKTTSPSSASSRATPPGTQDADEGHDVSDTFYTSQRKKGSHVFRVRLDATGFTLQRESPGG 66
            |.|.....||...|..::|..|.                       :.:.|..|...:||.||
Zfish    32 SNSNSCPNSPGGVSLPSSPASTN-----------------------YALTLTPTHIHVQRLSP-- 71

  Fly    67 SIVKEQHVRISDIVGARCMRPKKSRRLAMSGA----CACSSGNPNSPAISASGDHHRPATTPSKC 127
                               |..|..||.:..|    |:|    |.|||
Zfish    72 -------------------RAGKQSRLLLPMAELTGCSC----PRSPA----------------- 96

  Fly   128 STNSRDNIPSDGGDVSAFLYVFAYVLKKRSLRSELHRERTVLTLRFRSFDTFEDNMREADRWYRS 192
                           ...|.::.|...:|  |..:.|.|.|     |::  ..::..||::|..:
Zfish    97 ---------------PPLLVLYWYPPGRR--RKGVSRHRQV-----RAY--LAESRAEAEKWNAA 137

  Fly   193 LRWQLHRTLEEIFVAPTVD------ERRRRVLVLLNPKSGSGDAREVFNMHVTPVLNEAEVPYDL 251
            :: .|.|.::   |:.|.:      .|.||:|:|:||.||.|.|.:....|:.|::.||.:.|:|
Zfish   138 IQ-SLLRGMD---VSSTTEFCKSMLPRPRRLLLLVNPFSGRGQAMQWCQTHILPMIREANISYNL 198

  Fly   252 YVTKHSNFAIEFLSTRCLDAWCCVVAVGGDGLFHEIVNGLLQRQDWAHVLPHLALGIIPCGSGNG 316
            ..|:..|.|.|.:....|..|..:|.|.||||.||::|||::|.||...: ...:||:||||||.
Zfish   199 IQTERQNHARELIREISLPEWDGIVIVSGDGLLHEVINGLMERPDWEQAI-KTPVGILPCGSGNA 262

  Fly   317 LARSIAH------CYNEPYFSKPVLGAALTVISGRSSPMDVVRVQLQ----------------SR 359
            ||.||.|      |..||.    :|.....:..|...|:|:|.|...                .|
Zfish   263 LAGSINHHAGYDMCLREPL----LLNCCFLLCRGGVKPLDLVSVTTSPCASSSTSNQNGHPPAPR 323

  Fly   360 SLYSFLSIGWGLISDVDIESERIRMLGYQRFTVWTLYRLVNLRTYNGRISYL------------- 411
            .|:||||:.||.:|||||||||.|.||..|||:.||.||.:||:|.||:|||
Zfish   324 RLFSFLSVAWGFVSDVDIESERYRGLGSARFTLGTLVRLASLRSYKGRLSYLPPAVVNPSPDATP 388

  Fly   412 ----------LTD-------HEVSSTHSATGYAAQR----------------RMQSSRSCNTHID 443
                      :|:       ..:..|.|..|.:.||                |.:..|......|
Zfish   389 QPPRRPLSRSITEGLEGFCRTPIHRTCSDMGLSEQRSLRKDDGERERERERERQERERERERRRD 453

  Fly   444 MLNGPAPIYHSS-AEYLPQEFADVISLE----TSINQSFRSRCDSWL----------SGGSR--- 490
            ...|...:..|| ||...:|......:|    ||...:.|..||:..          ||.|:
Zfish   454 RARGVGVVRASSLAEDREREVEAEEKMEEMSGTSSESTERDECDNIAKNNGNEEENNSGKSKIDG 518

  Fly   491 ------RSF------------YYSISESIYHSL--------------------ADESEFAGLAAA 517
                  |:.            |.:....:.|:|                    ||..:...|||.
Zfish   519 QELTNARNLSDTNEVNDCDGSYQTTPPELQHALRKNSAPSSQIINAFFSQPIGADTDQDLELAAY 583

  Fly   518 SLEN------------------------------RQ------------QNYGPASELP------- 533
            ..|:                              ||            ||..|:...|
Zfish   584 GKEDEDINGTYFQKEAYSLDKSRERALTISSSPFRQSPFKAFKPKTLDQNQNPSRPRPLSLLHQS 648

  Fly   534 -----------------------------------------------------------DLNEP- 538
                                                                       ||.||
Zfish   649 HSNSLPPKFPSLSLSLSPTPPSSPSCASPHSSYLAPRPNTPSSSSPSPSIHSPTPSFNFDLAEPA 713

  Fly   539 --------------LSED------------QGWLVEEGEFVMMHAVYQTHLGIDCHFAPKAQLND 577
                          |.||            :.|:..||:||::.|:||:|||.|...||:|:.:|
Zfish   714 GPLKNRPHMTSSINLPEDDLLPPLDQPLPTRDWVTIEGDFVLVLAIYQSHLGADLLAAPQARFDD 778

  Fly   578 GTIYLILIRAGISRPHLLSFLYNMSSGTHLPESHDDHVKVLPVRAFRLEPYDNHGIITVDGERVE 642
            |.|:|..:||||||..||.....|..|.||..| ..:|..:..|||||:|....|.:|||||.|.
Zfish   779 GLIHLTFVRAGISRATLLRLFLAMERGAHLSLS-SPYVSHVSARAFRLQPLSPRGTLTVDGELVP 842

  Fly   643 FGPLQAEVLPGIARVMV 659
            :|||||:|.|.:||::|
Zfish   843 YGPLQAQVHPSMARLIV 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sk2	NP_647762.3	PLN02958	<213..639	CDD:215517	184/684 (27%)
		DAGK_cat	216..354	CDD:279163	56/143 (39%)
sphk2	XP_021322621.1	LCB5	<168..>376	CDD:332482	88/212 (42%)
		LCB5	<745..844	CDD:332482	46/99 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579709
Domainoid	1	1.000	191	1.000	Domainoid score	I3182
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2781
OMA	1	1.010	-	-		QHG47523
OrthoDB	1	1.010	-	-		D561206at33208
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	1	1.000	-	-		mtm6496
orthoMCL	1	0.900	-	-		OOG6_101566
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X918
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910