DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC5 and SMC3

DIOPT Version :9

Sequence 1:NP_996141.2 Gene:SMC5 / 326215 FlyBaseID:FBgn0052438 Length:1034 Species:Drosophila melanogaster
Sequence 2:NP_005436.1 Gene:SMC3 / 9126 HGNCID:2468 Length:1217 Species:Homo sapiens


Alignment Length:1295 Identity:259/1295 - (20%)
Similarity:477/1295 - (36%) Gaps:422/1295 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 IHSVYCKDFVSYSEIT----FHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADY 76
            |..|..:.|.||.:.|    |..||  ||:.|.||||||....||...|             :|.
Human     3 IKQVIIQGFRSYRDQTIVDPFSSKH--NVIVGRNGSGKSNFFYAIQFVL-------------SDE 52

  Fly    77 IQSNKTSATIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDTS-------KKN--FLAAVSSF 132
            ....:....:.:...|..|.....|..||..|..:...::.::.|       ||:  ||......
Human    53 FSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVT 117

  Fly   133 NIQVSNLCQFLPQDRVQDFSKMNPQELL----LNTMSS-----------------VCDEDLINSF 176
            ...|.||.:      ...||:.||..::    :|.|::                 |.||....|.
Human   118 KNDVMNLLE------SAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESI 176

  Fly   177 NSLKQMRTEQANVHA----------NREKEKSDLVKKQ---KRLEHLQMTVSQYKEREEVKQKLQ 228
            :.:|:...::..::.          ..|:||.:|.:.|   |....|:.|:.. :|..|.:.||.
Human   177 SLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYN-QELNETRAKLD 240

  Fly   229 VYSAKKLWVET------------QAGEAKAAEMKTQVKNAKTQSDKLKNQHDKL-LQSQEQIEK- 279
            ..|||:   ||            |....|..:::.||:..||:...:|.:.::| .:.||||:: 
Human   241 ELSAKR---ETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQR 302

  Fly   280 ----------------EKESLRKALLEKTRLLENAVAEK----AAIDGKMDSLKQ----GI---- 316
                            ..|..::.|.|:.:|||. :.||    |..:.|.:|:|:    ||    
Human   303 TKLELKAKDLQDELAGNSEQRKRLLKERQKLLEK-IEEKQKELAETEPKFNSVKEKEERGIARLA 366

  Fly   317 ------------------YQKKYELEQNIKKSRRTATECDNLNQLVENKIYELETLNKSRPLIVS 363
                              :..|.|.::.|||      |..:|:|.:.:|..::..::|.    :.
Human   367 QATQERTDLYAKQGRGSQFTSKEERDKWIKK------ELKSLDQAINDKKRQIAAIHKD----LE 421

  Fly   364 ELERAKESCAAARGKAMEQYSRRRQLEQKLNDEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPN 428
            :.|..||       |.:|||::   |:|.||:        .|.::|.|.    :|..|::.|...
Human   422 DTEANKE-------KNLEQYNK---LDQDLNE--------VKARVEELD----RKYYEVKNKKDE 464

  Fly   429 LVVAMN--WLAQNKQRYKLNVYDPMILELTVQNHEDAKFLENVVAQRDLFAFACEDKGDMS--DL 489
            |....|  |..:|.::..|           ....||.:..:.::.       |...|..::  |.
Human   465 LQSERNYLWREENAEQQAL-----------AAKREDLEKKQQLLR-------AATGKAILNGIDS 511

  Fly   490 INELC-------VKQKL-----GV--NVIYCAPS----------DRLVY--------SPKTPID- 521
            ||::.       :.|.:     |:  |...|.|:          :||.|        |.|..:: 
Human   512 INKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEF 576

  Fly   522 ------------DLRSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGTEAVGNYTSSIPKAIR 574
                        .|.....|..........||:|:||                 .|.....||.:
Human   577 NKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKL-----------------RYNPRFDKAFK 624

  Fly   575 VYFGGSKKFVVTASRYRSDTILTESSIRAKNQLITVDSQQL----AL-------------VMKQC 622
            ..||   |.::.    ||..:.|:.:.......||::..|:    ||             :.|..
Human   625 HVFG---KTLIC----RSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDV 682

  Fly   623 SEAVKE--------SDSIKNAITQTDNEFERLQAVAKDEQEKRRKL----DQKIAHFNSLKTE-- 673
            .:|.:|        :::::..|.:.:||.::|....:..:.::||.    |..::....||.:  
Human   683 RKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQ 747

  Fly   674 ------------IETLQKKLEALRNS-DSLDC-LETNFCNSLHKDLKKIFDADAELCSCLKAIDR 724
                        :::|:..|.|:.:: :||.. |.|:..:.|..:.:|..||..:....|:..:|
Human   748 QSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENR 812

  Fly   725 LIIEKNMAQ----TKVSIYMLQH--------ETQIEALKESE---------EQSKAATRDFQQLL 768
            .::.:.:..    |:|..|:.::        |.::..|:|:|         .:.:|..:..:..:
Human   813 QLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTM 877

  Fly   769 QCLENQISDVNKRKSAIQGLCHGEIPTSSK--FPFKKEFRELENIDLPELREAIHDFQARL---- 827
            ...|:..:.::|.::.|:     |:..|.:  ...:||..:..|.|..|| |.:.:.|..|    
Human   878 ARSEDLDNSIDKTEAGIK-----ELQKSMERWKNMEKEHMDAINHDTKEL-EKMTNRQGMLLKKK 936

  Fly   828 -ECMK------SVNSEAISSYQGLQNEVKQL------------------EEGIQESVN------- 860
             ||||      |:..||...||.|  .:|||                  ::.:.:.||       
Human   937 EECMKKIRELGSLPQEAFEKYQTL--SLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEK 999

  Fly   861 ---QAKSIESGMSNLYD--------KWEPKLNSLVETISTKFSEFMESIEYVGE--VVLSKTDKY 912
               :.:.::.|..::.:        |:| .:....:.:|..|||..:.:...|:  :|:.|.|..
Human  1000 LIKRQEELDRGYKSIMELMNVLELRKYE-AIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVE 1063

  Fly   913 ----------------------------DFDSYGIQIMVQFRRG--LQLQPLDKFIQSGGERAVS 947
                                        .|...||::....::|  .::|.|     |||::::.
Human  1064 GSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQL-----SGGQKSLV 1123

  Fly   948 IAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVT--PKLL 1005
            ......::|.....||...|||:|.:||.:.:.:.|::::.|.   .||::..|  |:||
Human  1124 ALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAV---HAQFITTTFRPELL 1180

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC5NP_996141.2 ABC_SMC5_euk 14..>160 CDD:213244 40/156 (26%)
Smc 22..1011 CDD:224117 257/1289 (20%)
GrpE 212..>316 CDD:295646 34/141 (24%)
ABC_SMC5_euk <919..1025 CDD:213244 24/91 (26%)
SMC3NP_005436.1 Smc 1..1194 CDD:224117 259/1295 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..269 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1059..1090 2/30 (7%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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