DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC5 and SMC5

DIOPT Version :9

Sequence 1:	NP_996141.2	Gene:	SMC5 / 326215	FlyBaseID:	FBgn0052438	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_014608.1	Gene:	SMC5 / 854123	SGDID:	S000005394	Length:	1093	Species:	Saccharomyces cerevisiae

Alignment Length:	1123	Identity:	282/1123 - (25%)
Similarity:	508/1123 - (45%)	Gaps:	203/1123 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSSKQLAGRIHSVYCKDFVSYSEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSA 71
            |||.| .|.|..:..:|||:|:...|:....||::.|||||||||.|.|:.|||.|:|..:.||.
Yeast    34 LSSFQ-PGSIIKIRLQDFVTYTLTEFNLSPSLNMIIGPNGSGKSTFVCAVCLGLAGKPEYIGRSK 97

  Fly    72 SVADYIQSNKTSATIIVRVYGRTPNTT---------ETFR--RII-NSNGLSTFSVNDKDTSKKN 124
            .|.|:|::.:..:.|.:.: ..:||.|         ||.:  ||| .|...|.:.:||...|:..
Yeast    98 KVEDFIKNGQDVSKIEITL-KNSPNVTDIEYIDARDETIKITRIITRSKRRSDYLINDYQVSESV 161

  Fly   125 FLAAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANV 189
            ....|:..|||:.||||||.|:||::|:::...:||:.|:.|: |..|::..:.|::::..:.::
Yeast   162 VKTLVAQLNIQLDNLCQFLSQERVEEFARLKSVKLLVETIRSI-DASLLDVLDELRELQGNEQSL 225

  Fly   190 HANREKEKSDLVKKQKRLEHLQMTVSQYKEREEVKQKLQVYSAKKLWVETQAGEAKAAEMKTQVK 254
            ..:.:.:|:.:|..::..:.|:.:|...::.:..|.:::::|....:|
Yeast   226 QKDLDFKKAKIVHLRQESDKLRKSVESLRDFQNKKGEIELHSQLLPYV----------------- 273

  Fly   255 NAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLEK------TRLLENAVAE------------ 301
                   |:|:..:||...:|:.|:.|.:||..|.:|      .:.|||.|.|
Yeast   274 -------KVKDHKEKLNIYKEEYERAKANLRAILKDKKPFANTKKTLENQVEELTEKCSLKTDEF 331

  Fly   302 -KA-----AIDGKMDSLKQGIYQKKYELEQ---NIKKSRRT--ATECDNL--------NQLVENK 347
             ||     .|..|:::::..:.:||.:.|.   ..||.:.|  :|:.|.|        ..|.|..
Yeast   332 LKAKEKINEIFEKLNTIRDEVIKKKNQNEYYRGRTKKLQATIISTKEDFLRSQEILAQTHLPEKS 396

  Fly   348 IYE------LETLNKSRPL--IVSELERAKESCAAARGKAMEQYSRRRQLEQKLNDEMIPEITAY 404
            ::|      .|.:||...:  ::||::      |.|.....|..|.:||.|.|.......:
Yeast   397 VFEDIDIKRKEIINKEGEIRDLISEID------AKANAINHEMRSIQRQAESKTKSLTTTD---- 451

  Fly   405 KLKIERLRNVKMQKIDEIRAKNPNLVVAMNWLAQNKQRYKLNVYDPMILELTVQNHEDAKFLENV 469
              ||..|.  :.|.:.|:|    :.|:    :.:.....|..:.:|.|:.::..|.:.|.:|...
Yeast   452 --KIGILN--QDQDLKEVR----DAVL----MVREHPEMKDKILEPPIMTVSAINAQFAAYLAQC 504

  Fly   470 VAQRDLFAFACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVD 534
            |......|....|........|.:..|.|:.:..:..|.:     :|..|.:.:|..||..||.|
Yeast   505 VDYNTSKALTVVDSDSYKLFANPILDKFKVNLRELSSADT-----TPPVPAETVRDLGFEGYLSD 564

  Fly   535 LVTGPIPLINKLCASYSIHNIPIGTEAVGNYTSSIPKAI-----------RVYFG---------- 578
            .:||...::..||.:..||.||:....:  ..:.|.|.|           |:..|
Yeast   565 FITGDKRVMKMLCQTSKIHTIPVSRREL--TPAQIKKLITPRPNGKILFKRIIHGNRLVDIKQSA 627

  Fly   579 -GSKKFVVT------ASRYRSDTILTESSIRAKNQLITVDSQQLALVMKQCSEAVKESDSIKNAI 636
             |||:...|      .:.|:...:..|..||.:|::|.:.::.        ::.....|::.|..
Yeast   628 YGSKQVFPTDVSIKQTNFYQGSIMSNEQKIRIENEIINLKNEY--------NDRKSTLDALSNQK 684

  Fly   637 TQTDNEFERLQAVAKDEQEKRRKLDQKIAHFNSLKTEIETLQKKLEALRNSDSLDCLETNFCNSL 701
            :...:|...|.:...|...:..:|::....:...|:.||||::||:.|:             ...
Yeast   685 SGYRHELSELASKNDDINREAHQLNEIRKKYTMRKSTIETLREKLDQLK-------------REA 736

  Fly   702 HKDL-KKIFDAD--------------AELCSCLKAIDRLIIEKNMAQTKVSIYMLQHETQ----- 746
            .||: :||.|.|              :::.|.:|::      ||..:..:|..:||.|.|
Yeast   737 RKDVSQKIKDIDDQIQQLLLKQRHLLSKMASSMKSL------KNCQKELISTQILQFEAQNMDVS 795

  Fly   747 ----IEALKESEEQSKAATRDFQQLLQCLENQISDVNKRKSAIQGLCHGEIPTSSKF-PFKKEFR 806
                |....|.|...|:...|.::.::    ::.|..:.:|.::.:...:..|..|. ...:::.
Yeast   796 MNDVIGFFNEREADLKSQYEDKKKFVK----EMRDTPEFQSWMREIRSYDQDTKEKLNKVAEKYE 856

  Fly   807 ELENIDLPELREAIHDFQARLECMKSVNSEAISSYQGLQNEVKQLEEGIQESVNQAKSIESGMSN 871
            |..|.:|..:::.:...::.: .|.:.:..|::....:..|:::||..:.:.....::|::.:..
Yeast   857 EEGNFNLSFVQDVLDKLESEI-AMVNHDESAVTILDQVTAELRELEHTVPQQSKDLETIKAKLKE 920

  Fly   872 LYDKWEPKLNSLVETISTKFSEFMESIEYVGEVVLSKTDKYDFDSYGIQIMVQFRRGLQLQPLDK 936
            .:...||||:.:|..||.:|:....::...|.|.|.|..  |:..:.|:|||:||....|:.||.
Yeast   921 DHAVLEPKLDDIVSKISARFARLFNNVGSAGAVRLEKPK--DYAEWKIEIMVKFRDNAPLKKLDS 983

  Fly   937 FIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVT 1001
            ..|||||||||..:|.::||..|..|||.|||||||||:.|||.:...:::.|....::||..:|
Yeast   984 HTQSGGERAVSTVLYMIALQEFTSAPFRVVDEINQGMDSRNERIVHKAMVENACAENTSQYFLIT 1048

  Fly  1002 PKLLRDLNYNEHL---CV 1016
            ||||..|:|:|.:   ||
Yeast  1049 PKLLTGLHYHEKMRIHCV 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	58/157 (37%)
		Smc	22..1011	CDD:224117	272/1098 (25%)
		GrpE	212..>316	CDD:295646	24/127 (19%)
		ABC_SMC5_euk	<919..1025	CDD:213244	50/101 (50%)
SMC5	NP_014608.1	Smc	42..1069	CDD:224117	277/1115 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344462
Domainoid	1	1.000	277	1.000	Domainoid score	I263
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41009
Inparanoid	1	1.050	294	1.000	Inparanoid score	I519
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54387
OrthoFinder	1	1.000	-	-		FOG0004754
OrthoInspector	1	1.000	-	-		oto100188
orthoMCL	1	0.900	-	-		OOG6_102083
Panther	1	1.100	-	-	LDO	PTHR45916
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1355
SonicParanoid	1	1.000	-	-		X3345
TreeFam	1	0.960	-	-
	15	14.790