Protein Alignment SMC5 and SMC3

DIOPT Version :9

• Sequence 1: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_012461.1
• Gene: SMC3 / 853371
• SGDID: S000003610
• Length: 1230
• Species: Saccharomyces cerevisiae
• Alignment Length: 1262
• Identity: 259/1262 - (20%)
• Similarity: 457/1262 - (36%)
• Gaps: 355/1262 - (28%)

  Fly    16 IHSVYCKDFVSYSEIT----FHPKHYLNVLTGPNGSGKSTIVSAI--IL---------------- 58
            |..|..|.|.:|...|    |.|  :.||:.|.||||||...:||  :|
Yeast     3 IKRVIIKGFKTYRNETIIDNFSP--HQNVIIGSNGSGKSNFFAAIRFVLSDDYSNLKREERQGLI 65

  Fly    59 --GLGGEPILLDRSASVADYIQSNKTSATIIVRVYGRTPNTTETFRRIINSNGL--STFSVNDKD 119
              |.||..:    ||||.........|..:...|..|..:.. |.||.:   ||  ..:.:||::
Yeast    66 HQGSGGSVM----SASVEIVFHDPDHSMILPSGVLSRGDDEV-TIRRTV---GLKKDDYQLNDRN 122

  Fly   120 TSKKNFLAAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLI--NSFN----- 177
            .:|.:.:..:.:....::|....:||.::...:....:|.|...      ||::  .||.
Yeast   123 VTKGDIVRMLETAGFSMNNPYNIVPQGKIVALTNAKDKERLQLL------EDVVGAKSFEVKLKA 181

  Fly   178 SLKQM-RTEQANVHANREKEKSDLVKKQKRLEHLQMTVSQYKERE----------------EVKQ 225
            |||:| .|||..:..|  ||..:|..|...:|..:..:.:|.|.|                ||..
Yeast   182 SLKKMEETEQKKIQIN--KEMGELNSKLSEMEQERKELEKYNELERNRKIYQFTLYDRELNEVIN 244

  Fly   226 KLQ---------VYSAKKL---------WVETQAGEAKAAEMKTQVKNA----------KTQSDK 262
            :::         |||:::.         .::..:.:..:.|...::|||          ...|.|
Yeast   245 QMERLDGDYNNTVYSSEQYIQELDKREDMIDQVSKKLSSIEASLKIKNATDLQQAKLRESEISQK 309

  Fly   263 LKNQHDKLLQSQEQIE--KEKESLRKALLEKTRLL---------------ENAVAEKAAIDGKMD 310
            |.|.:.|:...|:|||  :|:.:|..|.|::.:.:               :....|:|....::.
Yeast   310 LTNVNVKIKDVQQQIESNEEQRNLDSATLKEIKSIIEQRKQKLSKILPRYQELTKEEAMYKLQLA 374

  Fly   311 SLKQ---GIYQKKYELEQNIKKSRRTA---TECDNLNQLVENKIYELE--------TLNKSRPLI 361
            ||:|   .:..||.|..:...|..|..   :|.:.|...::| :.|||        :|.|....|
Yeast   375 SLQQKQRDLILKKGEYARFKSKDERDTWIHSEIEELKSSIQN-LNELESQLQMDRTSLRKQYSAI 438

  Fly   362 VSELERAKESCAA--ARGKAMEQYSRRRQLEQKLNDEMIPEITAYKLKIERLRNVKMQKIDEIRA 424
            ..|:|...:|...  .:|:..:..|....|:|||::.:......:: |.::|:.|....:.::..
Yeast   439 DEEIEELIDSINGPDTKGQLEDFDSELIHLKQKLSESLDTRKELWR-KEQKLQTVLETLLSDVNQ 502

  Fly   425 KNPNLVVAM-----NWLAQNKQ-RYKLNVYDPMIL----ELTVQNHEDAKFLENVVAQRDLFAFA 479
            ...|:...|     |.:...|: ..||.:....:.    || ::.::..|....|:....||...
Yeast   503 NQRNVNETMSRSLANGIINVKEITEKLKISPESVFGTLGEL-IKVNDKYKTCAEVIGGNSLFHIV 566

  Fly   480 CEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSP----------KTPIDDLRSFGFRSYLVD 534
            .:.:...:.::|||           |.....|:.:.|          |.|.:......|
Yeast   567 VDTEETATLIMNEL-----------YRMKGGRVTFIPLNRLSLDSDVKFPSNTTTQIQF------ 614

  Fly   535 LVTGPIPLINKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGGSKKFVV--------TASRYR 591
                 .|||.|:                 .|.....||::..||  |..||        .|.:::
Yeast   615 -----TPLIKKI-----------------KYEPRFEKAVKHVFG--KTIVVKDLGQGLKLAKKHK 655

  Fly   592 SDTILTESSIRAKNQLIT---VDSQQLALV--MKQCSEA-------VKESDSIKNAITQTDNEFE 644
            .:.|..:.....|..::|   :|..:...:  :|..:|:       ::|.|.::|.:...|.:.:
Yeast   656 LNAITLDGDRADKRGVLTGGYLDQHKRTRLESLKNLNESRSQHKKILEELDFVRNELNDIDTKID 720

  Fly   645 R----LQAVAKDEQ---------------EKRRKL-----------------------DQKIAHF 667
            :    ::.|:.|.:               :|..||                       .:|:..|
Yeast   721 QVNGNIRKVSNDRESVLTNIEVYRTSLNTKKNEKLILEESLNAIILKLEKLNTNRTFAQEKLNTF 785

  Fly   668 -NSL------------KTEIETLQKKLEALRN-----SDSLDCLETNFCNSLHKDLK-KIFDADA 713
             |.|            |..:|:|.|::.|..|     ||:|:.:.|.. :||:.:|: |:...:.
Yeast   786 ENDLLQEFDSELSKEEKERLESLTKEISAAHNKLNITSDALEGITTTI-DSLNAELESKLIPQEN 849

  Fly   714 ELCSCLKAI---------DRLIIEKNMAQTKVSIYMLQHET----------QIEALKESEEQSK- 758
            :|.|.:..:         |.|   |.:...|.|:.. |||.          :||:|...|..:|
Yeast   850 DLESKMSEVGDAFIFGLQDEL---KELQLEKESVEK-QHENAVLELGTVQREIESLIAEETNNKK 910

  Fly   759 ---AATRDFQQLLQCLENQISDVNK----------RKSAIQGLCHGEIPTSSKFPFKKEFRELEN 810
               .|....:.||:.|:|....|.|          |:..:|    ..|......|......:..:
Yeast   911 LLEKANNQQRLLLKKLDNFQKSVEKTMIKKTTLVTRREELQ----QRIREIGLLPEDALVNDFSD 971

  Fly   811 IDLPELREAIHDFQARLECMKSVNSEAISSYQGLQNEVKQLEEGIQESVNQAKSIESGMSNLYDK 875
            |...:|.:.::|....:..:|:||..|..:::......|.|.|...|......||:..:..|..:
Yeast   972 ITSDQLLQRLNDMNTEISGLKNVNKRAFENFKKFNERRKDLAERASELDESKDSIQDLIVKLKQQ 1036

  Fly   876 WEPKLNSLVETISTKFSEFMESIEYVGE---VVLSKTDK---------YDFDS------------ 916
            ....::|..:.:|..|....|.:...|.   ::..|.|.         .|.|:
Yeast  1037 KVNAVDSTFQKVSENFEAVFERLVPRGTAKLIIHRKNDNANDHDESIDVDMDAESNESQNGKDSE 1101

  Fly   917 ---YGIQIMVQF----RRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMD 974
               .|:.|.|.|    ...|.::.|     |||::.|......|::|.|....|...|||:..:|
Yeast  1102 IMYTGVSISVSFNSKQNEQLHVEQL-----SGGQKTVCAIALILAIQMVDPASFYLFDEIDAALD 1161

  Fly   975 ATNERHIFDLLLKEATKHGSAQYLFVT 1001
             ...|.....||||.:|  :||::..|
Yeast  1162 -KQYRTAVATLLKELSK--NAQFICTT 1185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	42/169 (25%)
		Smc	22..1011	CDD:224117	257/1256 (20%)
		GrpE	212..>316	CDD:295646	30/167 (18%)
		ABC_SMC5_euk	<919..1025	CDD:213244	26/87 (30%)
SMC3	NP_012461.1	Smc	1..1221	CDD:224117	259/1262 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810