Protein Alignment SMC5 and SMC4

DIOPT Version :9

• Sequence 1: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_013187.1
• Gene: SMC4 / 850775
• SGDID: S000004076
• Length: 1418
• Species: Saccharomyces cerevisiae
• Alignment Length: 1337
• Identity: 256/1337 - (19%)
• Similarity: 493/1337 - (36%)
• Gaps: 435/1337 - (32%)

  Fly     4 DRALSSKQLAGR--IHSVYCKDFVSYS--EIT--FHPKHYLNVLTGPNGSGKSTIVSAI--ILGL 60
            ||..||.:...|  |:.:..::|.||:  ::.  ||..  .:.:.||||||||.::.::  :.|.
Yeast   142 DRHQSSSKQQSRLFINELVLENFKSYAGKQVVGPFHTS--FSAVVGPNGSGKSNVIDSMLFVFGF 204

  Fly    61 GGEPILLDR---------------SASVADYIQ-----SNKTSATIIVRVYGRTPN---TTETFR 102
            ....:..||               |.|||.:.|     |:.||     |:....|.   |.:.|:
Yeast   205 RANKMRQDRLSDLIHKSEAFPSLQSCSVAVHFQYVIDESSGTS-----RIDEEKPGLIITRKAFK 264

  Fly   103 RIINSNGLSTFSVNDKDTSKKNFLAAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQ------ELLL 161
                 |..|.:.:|:|::|.......:.:..|.:.:....:.|..|::.::|.|:      :.||
Yeast   265 -----NNSSKYYINEKESSYTEVTKLLKNEGIDLDHKRFLILQGEVENIAQMKPKAEKESDDGLL 324

  Fly   162 NTMSSVCDEDLINSFN-------------SLKQMRTEQANVHANREKEKSDL----------VKK 203
            ..:     ||:|.:.|             :|.::..|:.|.....::||:.|          ::|
Yeast   325 EYL-----EDIIGTANYKPLIEERMGQIENLNEVCLEKENRFEIVDREKNSLESGKETALEFLEK 384

  Fly   204 QKRLEHLQMTVSQYK-----------------------------------------EREEVKQKL 227
            :|:|..|:..:.|:|                                         :|:|:|.::
Yeast   385 EKQLTLLRSKLFQFKLLQSNSKLASTLEKISSSNKDLEDEKMKFQESLKKVDEIKAQRKEIKDRI 449

  Fly   228 QVYSAKK--LWVETQAGEAKAAEMKTQVKNAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLE 290
            ...|:|:  |.:|.:..|.....::.:.||              |:...|:.||..:|.:.::.|
Yeast   450 SSCSSKEKTLVLERRELEGTRVSLEERTKN--------------LVSKMEKAEKTLKSTKHSISE 500

  Fly   291 KTRLLENAVAEKAAIDGKMDSLKQGIYQKKYELEQNIKKSRRTAT-------------------- 335
            ...:||....::...:.::..|.| :.:|:..:..:||.|.:..|
Yeast   501 AENMLEELRGQQTEHETEIKDLTQ-LLEKERSILDDIKLSLKDKTKNISAEIIRHEKELEPWDLQ 564

  Fly   336 --ECDNLNQLVENKIYELETLNKSRPLIVSELERAKESCAAARGKAMEQYSRRRQLEQKLN---D 395
              |.::..||.|:   ||..|.:::..:...:|..:|...|.:....|.......|::|||   |
Yeast   565 LQEKESQIQLAES---ELSLLEETQAKLKKNVETLEEKILAKKTHKQELQDLILDLKKKLNSLKD 626

  Fly   396 EMI---PEITAYKLKIERLR---NVKMQKIDEIR---AKNPNLVVAMNWLAQNKQRYKLNVYDPM 451
            |..   ...|:..||::.::   |...|:..|.|   :|..|....:..|::.::..::|.:...
Yeast   627 ERSQGEKNFTSAHLKLKEMQKVLNAHRQRAMEARSSLSKAQNKSKVLTALSRLQKSGRINGFHGR 691

  Fly   452 ILELTVQNHEDAKFLENVVAQRDLFAFACEDKGDMSDLINELCVK-QKLGVNVIYCAP------- 508
            :.:|.|                      .:|..|::  |:..|.: ..:.|:.:.||.
Yeast   692 LGDLGV----------------------IDDSFDVA--ISTACPRLDDVVVDTVECAQHCIDYLR 732

  Fly   509 SDRLVYSPKTPIDDLRSFGFRSY--------LVDLVTGPIPLINKLCASYSIHNIPIGTEAVGNY 565
            .::|.|:....:|.||.|..:..        |.|||....|..:.  |.||:....:       .
Yeast   733 KNKLGYARFILLDRLRQFNLQPISTPENVPRLFDLVKPKNPKFSN--AFYSVLRDTL-------V 788

  Fly   566 TSSIPKAIRVYFGGSKKFVVTA------------------------------------SRYRSDT 594
            ..::.:|..|.:|..:..|||.                                    :....|.
Yeast   789 AQNLKQANNVAYGKKRFRVVTVDGKLIDISGTMSGGGNHVAKGLMKLGTNQSDKVDDYTPEEVDK 853

  Fly   595 ILTESSIRAKNQLITVDS-----QQLALVM-------KQCSEAVKESDSIKNAITQTDNEFERLQ 647
            |..|.|.|..|..:..|:     ::|..:.       .|.|:|..|:||:.:.:|..:.:.:..:
Yeast   854 IERELSERENNFRVASDTVHEMEEELKKLRDHEPDLESQISKAEMEADSLASELTLAEQQVKEAE 918

  Fly   648 -AVAKDEQEK------RRKLDQKIAHFNSLKTEIETLQKKLEALRNS-DSLDCLETNFCNS---- 700
             |..|...:|      .:.|::....:|.|::|.:|.::|::.|::. ..:..::....||
Yeast   919 MAYVKAVSDKAQLNVVMKNLERLRGEYNDLQSETKTKKEKIKGLQDEIMKIGGIKLQMQNSKVES 983

  Fly   701 -------LHKDLKKIFDA--------------------DAELCSCLKAIDRL-IIEKNMAQTKVS 737
                   |...|||:..|                    |.||.|     |.| :||:.:..||::
Yeast   984 VCQKLDILVAKLKKVKSASKKSGGDVVKFQKLLQNSERDVELSS-----DELKVIEEQLKHTKLA 1043

  Fly   738 IYMLQHETQIE-------ALKESEEQSKAATRDFQQ---------------------LLQCLENQ 774
              :.:::|.:.       .|||..||.|....|.::                     ||..::::
Yeast  1044 --LAENDTNMNETLNLKVELKEQSEQLKEQMEDMEESINEFKSIEIEMKNKLEKLNSLLTYIKSE 1106

  Fly   775 ISDVNK--RKSAIQGLCH--GEIPTSSKFPFK----------KEFRELENIDLPELREAIHDFQA 825
            |:...|  .:.:|:.:.|  |.:..:.....|          :|:|..|..|..|:::|    :.
Yeast  1107 ITQQEKGLNELSIRDVTHTLGMLDDNKMDSVKEDVKNNQELDQEYRSCETQDESEIKDA----ET 1167

  Fly   826 RLECMKSVN----SEAISSYQGL----QNEVKQLE-EGIQESVNQAK------SIESGMSNLY-- 873
            ..:....:|    |:.:|  :|:    ::|:::|: |.|:..:|:..      :::.|:...|
Yeast  1168 SCDNYHPMNIDETSDEVS--RGIPRLSEDELRELDVELIESKINELSYYVEETNVDIGVLEEYAR 1230

  Fly   874 -----DKWEPKLNSLVE-----------TISTKFSEFMESIEYV--------------GEVVLSK 908
                 .:.:..||:.|:           ....:|.|||.....:              |...|..
Yeast  1231 RLAEFKRRKLDLNNAVQKRDEVKEQLGILKKKRFDEFMAGFNIISMTLKEMYQMITMGGNAELEL 1295

  Fly   909 TDKYDFDSYGIQIMV-----QFRRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTH----VPFR 964
            .|..|..|.|:...|     .:|....|        ||||:.:|    ||:|....|    .|..
Yeast  1296 VDSLDPFSEGVTFSVMPPKKSWRNITNL--------SGGEKTLS----SLALVFALHKYKPTPLY 1348

  Fly   965 CVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVT 1001
            .:|||:..:|..|...:.: .:||.||  :||::.::
Yeast  1349 VMDEIDAALDFRNVSIVAN-YIKERTK--NAQFIVIS 1382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	40/182 (22%)
		Smc	22..1011	CDD:224117	250/1317 (19%)
		GrpE	212..>316	CDD:295646	22/146 (15%)
		ABC_SMC5_euk	<919..1025	CDD:213244	24/92 (26%)
SMC4	NP_013187.1	Smc	154..1418	CDD:224117	251/1325 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810