Protein Alignment SMC5 and SMC2

DIOPT Version :9

• Sequence 1: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_116687.1
• Gene: SMC2 / 850589
• SGDID: S000001927
• Length: 1170
• Species: Saccharomyces cerevisiae
• Alignment Length: 1256
• Identity: 245/1256 - (19%)
• Similarity: 467/1256 - (37%)
• Gaps: 379/1256 - (30%)

  Fly    15 RIHSVYCKDFVSYSEIT----FHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVAD 75
            ::..:....|.||:..|    :.|:  .|.:||.||||||.|:.||...||...:...|::|:.|
Yeast     2 KVEELIIDGFKSYATRTVITDWDPQ--FNAITGLNGSGKSNILDAICFVLGIASMSTVRASSLQD 64

  Fly    76 YI----QSNKTSATIIVRVYGRTPNTTE----------TFRRIINSNGLSTFSVNDKDTSKKNFL 126
            .|    |:..|.|::.: |:..|..:..          :..|.:...|.|.:.:|.....:::.|
Yeast    65 LIYKRGQAGVTKASVTI-VFDNTDKSNSPIGFTNSPQISVTRQVVLGGTSKYLINGHRAPQQSVL 128

  Fly   127 AAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANVHA 191
            ....|..:.::|....:.|.::.....|.|.|:|          .||......|....
Yeast   129 QLFQSVQLNINNPNFLIMQGKITKVLNMKPSEIL----------SLIEEAAGTKMFED------- 176

  Fly   192 NREKEKSDLVKKQKRLEHLQMTVSQYKEREEVKQKLQ-VYSAKKLWVETQAGEA----------- 244
            .|||.:..:.||:.:|:..:..::     ||::.||: :.:.|::::|.|:.:.
Yeast   177 RREKAERTMSKKETKLQENRTLLT-----EEIEPKLEKLRNEKRMFLEFQSTQTDLEKTERIVVS 236

  Fly   245 --------KAAEMKTQVKNAKTQS-------DKLKNQHDKLLQSQEQI--EKEKESLRKALLEKT 292
                    |...::..::|.:|:.       .|...:.|.|.:..|:|  :||||..::..:.|.
Yeast   237 YEYYNIKHKHTSIRETLENGETRMKMLNEFVKKTSEEIDSLNEDVEEIKLQKEKELHKEGTISKL 301

  Fly   293 RLLENAVAE-----KAAIDGKMDSLKQGIYQKKYELEQNI---------KKSRRTATECDNLNQL 343
            ...||.:..     |.::..|:::|.. ..:|...||..|         |||....||.|  .::
Yeast   302 ENKENGLLNEISRLKTSLSIKVENLND-TTEKSKALESEIASSSAKLIEKKSAYANTEKD--YKM 363

  Fly   344 VENKIYELETLNKSRPLIVSELERAKESCAAARGKAMEQYSRRRQLEQKLNDEMIPEITAYKLKI 408
            |:.::.:...|.|.:..:||.|.....|..||.|....|.::.:   .:|| |:...|....:|:
Yeast   364 VQEQLSKQRDLYKRKEELVSTLTTGISSTGAADGGYNAQLAKAK---TELN-EVSLAIKKSSMKM 424

  Fly   409 ERLR-------------------NVK-----MQKIDEIRAK------NPNLVVAMNWLAQNKQRY 443
            |.|:                   |||     .:..|::||:      :|:.:   ..|.|.:.:.
Yeast   425 ELLKKELLTIEPKLKEATKDNELNVKHVKQCQETCDKLRARLVEYGFDPSRI---KDLKQREDKL 486

  Fly   444 KLNVY----DPMILELTVQNHE----------DAKFLENVVAQ-----RD--------------- 474
            |.:.|    :...|:..|.|.|          :|.|:..||.|     .|
Yeast   487 KSHYYQTCKNSEYLKRRVTNLEFNYTKPYPNFEASFVHGVVGQLFQIDNDNIRYATALQTCAGGR 551

  Fly   475 LFAFACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVDL---- 535
            ||....:|....:.|:....::::  |.:|              |:|.:.:....|.::||
Yeast   552 LFNVVVQDSQTATQLLERGRLRKR--VTII--------------PLDKIYTRPISSQVLDLAKKI 600

  Fly   536 VTGPIPL-INKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGGS--------KKFVVTASRYR 591
            ..|.:.| ||.:                 .:..||.||:...||.|        .|.:....:.|
Yeast   601 APGKVELAINLI-----------------RFDESITKAMEFIFGNSLICEDPETAKKITFHPKIR 648

  Fly   592 SDTILTESSI-----------RAKNQLITVDSQQLALVMKQ------------------------ 621
            :.:|..:..:           |..::.:.||.|:...:.||
Yeast   649 ARSITLQGDVYDPEGTLSGGSRNTSESLLVDIQKYNQIQKQIETIQADLNHVTEELQTQYATSQK 713

  Fly   622 --------------------------CSEAVKESDSIKNAITQTDNEFERLQAVAKDEQEKRRKL 660
                                      .|:.:..::.|...|.:.:||.:..|...|..||:...:
Yeast   714 TKTIQSDLNLSLHKLDLAKRNLDANPSSQIIARNEEILRDIGECENEIKTKQMSLKKCQEEVSTI 778

  Fly   661 DQKIAHF--------NSLKTEIETLQKKLEALRNSDS---------LDCLETNFCNS-------- 700
            ::.:..:        |.||.|::.|.|:||. :.|:|         |: |||...:|
Yeast   779 EKDMKEYDSDKGSKLNELKKELKLLAKELEE-QESESERKYDLFQNLE-LETEQLSSELDSNKTL 841

  Fly   701 LHKDLK-----KIFDADAELCSCLKAI--DRLIIEKNMAQTKVSIYMLQHE-TQIEAL-KESEEQ 756
            ||..||     |:.::|.|  ..::.:  |.:.::..:.:.|..:..:..| .::|.| |:.:::
Yeast   842 LHNHLKSIESLKLENSDLE--GKIRGVEDDLVTVQTELNEEKKRLMDIDDELNELETLIKKKQDE 904

  Fly   757 SKAATRDFQQLLQCLENQISDVNKRKSAIQGLCHGEIPTSSKFPFKKEFRELENI--DLPELREA 819
            .|::..:.|:|       :.|:||                    :|.....:|.|  ||.:..|.
Yeast   905 KKSSELELQKL-------VHDLNK--------------------YKSNTNNMEKIIEDLRQKHEF 942

  Fly   820 IHDFQARLECMKSVNSEAISSYQGLQNEVKQLEEGIQESVNQAKSIESGMSNLYDKWEPK---LN 881
            :.||......:|......:.:|   :...|||.|..||   ..|.:...:.|:.:..|.|   |.
Yeast   943 LEDFDLVRNIVKQNEGIDLDTY---RERSKQLNEKFQE---LRKKVNPNIMNMIENVEKKEAALK 1001

  Fly   882 SLVETISTKFSEFMESI----EYVGEVVLSKTDKYDFD------------------------SYG 918
            ::::||.....:..|:|    ||..|.::...:|...|                        :.|
Yeast  1002 TMIKTIEKDKMKIQETISKLNEYKRETLVKTWEKVTLDFGNIFADLLPNSFAKLVPCEGKDVTQG 1066

  Fly   919 IQIMVQFRRGLQLQPLDKFIQ-SGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIF 982
            :::.|:.....:    :..|: |||:|::......::|......|...:||::..:|.::.::|.
Yeast  1067 LEVKVKLGNIWK----ESLIELSGGQRSLIALSLIMALLQFRPAPMYILDEVDAALDLSHTQNIG 1127

  Fly   983 DLLLKEATKHGSAQYLFVTPK 1003
            .|:   .|:...:|::.|:.|
Yeast  1128 HLI---KTRFKGSQFIVVSLK 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	39/162 (24%)
		Smc	22..1011	CDD:224117	245/1249 (20%)
		GrpE	212..>316	CDD:295646	25/137 (18%)
		ABC_SMC5_euk	<919..1025	CDD:213244	17/86 (20%)
SMC2	NP_116687.1	Smc	1..1169	CDD:224117	245/1256 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810