DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC5 and SMC1

DIOPT Version :9

Sequence 1:NP_996141.2 Gene:SMC5 / 326215 FlyBaseID:FBgn0052438 Length:1034 Species:Drosophila melanogaster
Sequence 2:NP_116647.1 Gene:SMC1 / 850540 SGDID:S000001886 Length:1225 Species:Saccharomyces cerevisiae


Alignment Length:1271 Identity:249/1271 - (19%)
Similarity:490/1271 - (38%) Gaps:362/1271 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 GRIHSVYCKDFVSYSEIT---FHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEP----------- 64
            ||:..:...:|.||..:|   |...::.::: ||||||||.::.||...||...           
Yeast     2 GRLVGLELSNFKSYRGVTKVGFGESNFTSII-GPNGSGKSNMMDAISFVLGVRSNHLRSNILKDL 65

  Fly    65 ----ILLDRSASVADY-----IQSNKTSATIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDT 120
                :|.|.::.  ||     ..||..||  .|:.:.:..|......|||:.||.:::.::.|..
Yeast    66 IYRGVLNDENSD--DYDNEGAASSNPQSA--YVKAFYQKGNKLVELMRIISRNGDTSYKIDGKTV 126

  Fly   121 SKKNFLAAVSSFN--IQVSNLCQFLPQDRVQDFSKMNPQEL--LLNTMSSVCD-----EDLINSF 176
            |.|::...:.:.|  |:..|...|  |..|:..:..:|.||  :...:|....     |:|....
Yeast   127 SYKDYSIFLENENILIKAKNFLVF--QGDVEQIAAQSPVELSRMFEEVSGSIQYKKEYEELKEKI 189

  Fly   177 NSLKQMRTE----QANVHANREKEKSDLVKKQKRLEHLQMTVSQYKEREEVKQKLQVYSAKKLW- 236
            ..|.:..||    :..:|...:..|..:.|.:           :|:::.:.|.:||.:.|  || 
Yeast   190 EKLSKSATESIKNRRRIHGELKTYKEGINKNE-----------EYRKQLDKKNELQKFQA--LWQ 241

  Fly   237 ---VETQAGEA--KAAEMKTQVKNAKTQSDKLKNQHDKLLQSQEQ-------IEKEKESLRKALL 289
               :|.|..|.  |.:.:.:::.:.|   .|:.|:...|.:|:..       |.|:|..|.....
Yeast   242 LYHLEQQKEELTDKLSALNSEISSLK---GKINNEMKSLQRSKSSFVKESAVISKQKSKLDYIFK 303

  Fly   290 EKTRLLEN----AVAEKAA------IDGKMDSL-----KQGIYQKKYE------------LEQNI 327
            :|.:|:.:    .|.::||      |:.:::||     :|..|.:::|            .|:.|
Yeast   304 DKEKLVSDLRLIKVPQQAAGKRISHIEKRIESLQKDLQRQKTYVERFETQLKVVTRSKEAFEEEI 368

  Fly   328 KKSRR-------TATECDNLNQLVENKIYE--------LETLNKSRPLIVSELERAKESCAAARG 377
            |:|.|       ...:....|.|.|..:.|        :..||..:..|..||||..:....::.
Yeast   369 KQSARNYDKFKLNENDLKTYNCLHEKYLTEGGSILEEKIAVLNNDKREIQEELERFNKRADISKR 433

  Fly   378 KAMEQYS-RRRQLEQKLNDEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMNWLAQNKQ 441
            :..|:.| ...:|:.:|||..:.......|..|||..:|..:.|...|              |.|
Yeast   434 RITEELSITGEKLDTQLNDLRVSLNEKNALHTERLHELKKLQSDIESA--------------NNQ 484

  Fly   442 RYKLN--VYDPMIL--ELTVQNHE---DAKFLENVVAQRDLFAFACEDKGDMSDLINELCVKQK- 498
            .|.||  :.:.::.  :|:....|   :.|..||:...:..|.       .:..|:::||..:| 
Yeast   485 EYDLNFKLRETLVKIDDLSANQRETMKERKLRENIAMLKRFFP-------GVKGLVHDLCHPKKE 542

  Fly   499 ---LGVNVIYCAPSDRLVYSPKTPIDDLRSF------GFRSYL-VDLVTGPIPLINKLCASYSIH 553
               |.|:.|.....|.::....|...:..:|      |..|:: :|.:...:|.:          
Yeast   543 KYGLAVSTILGKNFDSVIVENLTVAQECIAFLKKQRAGTASFIPLDTIETELPTL---------- 597

  Fly   554 NIP------IGTEAVGNYTSSIPKAIRVYFGGSKKFVVTASRYRSDTILTESSIRAKNQLITVDS 612
            ::|      :...|: :|.....||::...|.|   ::..:...:..:..:..||.|  |:|::.
Yeast   598 SLPDSQDYILSINAI-DYEPEYEKAMQYVCGDS---IICNTLNIAKDLKWKKGIRGK--LVTIEG 656

  Fly   613 QQLALVMK-----------------------------------------QCSEAVKESDSIKNAI 636
               ||:.|                                         |.|.:::..: ::|::
Yeast   657 ---ALIHKAGLMTGGISGDANNRWDKEEYQSLMSLKDKLLIQIDELSNGQRSNSIRARE-VENSV 717

  Fly   637 TQTDNEFERLQAVAKDEQEKRRKLDQ---KIAHFNSL-----KTEIETLQKKLEALRNS-DSL-- 690
            :..:::...|:.   ...:::|.||:   :|.:.|.|     :.:|..|:|||:.|.|: |:|  
Yeast   718 SLLNSDIANLRT---QVTQQKRSLDENRLEIKYHNDLIEKEIQPKITELKKKLDDLENTKDNLVK 779

  Fly   691 --DCLETN----FCNSLHKDLKKIFDADAEL----CSCLKAIDRLII------------------ 727
              :.|:.|    |.:.:...:|:..:...||    ...|:.:.:.|:                  
Yeast   780 EKEALQNNIFKEFTSKIGFTIKEYENHSGELMRQQSKELQQLQKQILTVENKLQFETDRLSTTQR 844

  Fly   728 -----EKNMAQTKVSIYMLQH------------ETQIEALKE--SEEQSKAATRDFQQLLQCLEN 773
                 :|::...:|.:..|:.            |:::|..|.  .|.|.|..|:  |..|...|:
Yeast   845 RYEKAQKDLENAQVEMKSLEEQEYAIEMKIGSIESKLEEHKNHLDELQKKFVTK--QSELNSSED 907

  Fly   774 QISDVNKRKSAIQGLCHGEIPTSSKFPFKK----EFRELENIDLPELRE-AIHDFQARLECMKSV 833
            .:.|:|.....::....|......||..::    :..::.||::|...| .|.|..     :.|.
Yeast   908 ILEDMNSNLQVLKRERDGIKEDIEKFDLERVTALKNCKISNINIPISSETTIDDLP-----ISST 967

  Fly   834 NSEAIS-------SYQG----------------LQNEVKQLEEGIQESVNQAKSIESGMSNLYDK 875
            ::|||:       :|:|                |:.::.::||.:.|....|:::|.     ||:
Yeast   968 DNEAITISNSIDINYKGLPKKYKENNTDSARKELEQKIHEVEEILNELQPNARALER-----YDE 1027

  Fly   876 WEPK------------------LNSLVETISTKFSEFMESIEYVGEVV------LSKTDKYDFDS 916
            .|.:                  ||..::....:...|.::.:||.:.:      |:|....:.:.
Yeast  1028 AEGRFEVINNETEQLKAEEKKILNQFLKIKKKRKELFEKTFDYVSDHLDAIYRELTKNPNSNVEL 1092

  Fly   917 YG--IQIMVQ-----FRRGLQLQ---PLDKF----IQSGGERAVSIAIYSLSLQHVTHVPFRCVD 967
            .|  ..:.::     |..|::..   ||.:|    ..||||:.|:......::......||..:|
Yeast  1093 AGGNASLTIEDEDEPFNAGIKYHATPPLKRFKDMEYLSGGEKTVAALALLFAINSYQPSPFFVLD 1157

  Fly   968 EINQGMDATNERHIFDLLLKEATKHGSAQYLFVTPK 1003
            |::..:|.||.:.|...:.:.  ::...|::.::.|
Yeast  1158 EVDAALDITNVQRIAAYIRRH--RNPDLQFIVISLK 1191

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC5NP_996141.2 ABC_SMC5_euk 14..>160 CDD:213244 46/172 (27%)
Smc 22..1011 CDD:224117 247/1263 (20%)
GrpE 212..>316 CDD:295646 29/131 (22%)
ABC_SMC5_euk <919..1025 CDD:213244 20/97 (21%)
SMC1NP_116647.1 Smc 3..1225 CDD:224117 248/1270 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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