Protein Alignment SMC5 and SMC6

DIOPT Version :9

• Sequence 1: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: XP_011531409.1
• Gene: SMC6 / 79677
• HGNCID: 20466
• Length: 1110
• Species: Homo sapiens
• Alignment Length: 1195
• Identity: 258/1195 - (21%)
• Similarity: 460/1195 - (38%)
• Gaps: 348/1195 - (29%)

  Fly    14 GRIHSVYCKDFVSYSEI-TFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYI 77
            |.|.|::.|:|:.:|.: .|.....:|.:.|.||||||.:::|:|:||||..:..:|.:|:..::
Human    46 GIIESIHLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFV 110

  Fly    78 QSNKTSATIIVRVYGRTPNTTETFRRIINSNGL------------------STFSVNDKDTSKKN 124
            :..:.||.|.:.:..|   ..:.|:..:..|.:                  :|.||  ..|.|:.
Human   111 KDGQNSADISITLRNR---GDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSV--VSTRKEE 170

  Fly   125 FLAAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSF---NSLKQMRTEQ 186
            .:|.:..|||||.|....|.|:..:.|            :.|..:.|....|   ..|:||:.:.
Human   171 LIAILDHFNIQVDNPVSVLTQEMSKQF------------LQSKNEGDKYKFFMKATQLEQMKEDY 223

  Fly   187 ANVHANREKEKSDLVKKQKRLEHLQMTVSQYKEREEVKQKLQVYSAKKLWVETQAGEAKAAEMKT 251
            :.:...:|:.|..:.:.::||..|:   .|..|:||..|.:                |..:.|||
Human   224 SYIMETKERTKEQIHQGEERLTELK---RQCVEKEERFQSI----------------AGLSTMKT 269

  Fly   252 QVKNAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLEKTRLLENAVAEKAAIDGKMD--SLKQ 314
            .:::.|         |:.......:|||:..::|    :..::.|:..|.   :|.||:  .::.
Human   270 NLESLK---------HEMAWAVVNEIEKQLNAIR----DNIKIGEDRAAR---LDRKMEEQQVRL 318

  Fly   315 GIYQKKY-----ELEQNIKKSRRTATECDNL--NQLVENKIY-ELETL-NKSRPLIVSELERAKE 370
            ...::||     :||:..:::...|.||..|  :.:.:.:.| |.|.| |:|    ::|.:..|
Human   319 NEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRS----LNEYKALK- 378

  Fly   371 SCAAARGKAMEQYSRR-RQLEQKLNDEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMN 434
                   |..||..:| .:|::..:..:.||      ::||.:.:                   :
Human   379 -------KDDEQLCKRIEELKKSTDQSLEPE------RLERQKKI-------------------S 411

  Fly   435 WLAQNKQRYKLNVYDPMILELTVQNHEDAKFLENVVAQRDLFAFACE-DKGDMSDL-INELCVKQ 497
            ||   |:|.|           ..||.|:     :|..:.:.|..|.| ||.:...: ..||.||.
Human   412 WL---KERVK-----------AFQNQEN-----SVNQEIEQFQQAIEKDKEEHGKIKREELDVKH 457

  Fly   498 KLGVN-----VIYCAPSDRLV-YSPKTP-----IDDLRSFGFRSYLVDLVTGPI----------- 540
            .|..|     .:..:.:|||. :.|..|     |||....|..:|   ...||:
Human   458 ALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTY---KPVGPLGACIHLRDPEL 519

  Fly   541 -----PLINKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGGSKKFVVTASRYRSD------- 593
                 ..:..|..:|..||     .|......::.|  |.|..|:.:..:..|.:|::
Human   520 ALAIESCLKGLLQAYCCHN-----HADERVLQALMK--RFYLPGTSRPPIIVSEFRNEIYDVRHR 577

  Fly   594 --------TILTESSIR---AKNQLITVDSQQLALVM----------------KQCSEAVKE--- 628
                    |:||...|.   ..|.||.:...:..|::                |.|.||...
Human   578 AAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGD 642

  Fly   629 ------------------SDSIKNAITQTDNEFE-----------RLQAVAKDEQEKRRKLDQKI 664
                              |..:.:.|:..:||.|           .|.|:.||.:.....|.:..
Human   643 QVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQ 707

  Fly   665 AHFNSLKTEIETLQKKLEALRNSDSLDCLETNFCNSLHK--DLKKIFDADAELCSCLKAIDRLII 727
            .|:..||.:|   :|.:..:|..::::         .|:  |:..:.|...|..|.:|     ::
Human   708 LHYKELKMKI---RKNISEIRELENIE---------EHQSVDIATLEDEAQENKSKMK-----MV 755

  Fly   728 EKNMAQTKVSIYMLQHETQIEALK-ESEEQSKAATRDFQQLLQCLENQISDVNKRKSAI----QG 787
            |::|.|.|.:   ::|   :::|| |:|.:..|......||.:..:....::|...|.:    :|
Human   756 EEHMEQQKEN---MEH---LKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRG 814

  Fly   788 LCHGE------IPTSSKFPFKKEFRELENIDLPE-LREAIHDFQARLECMKSVN----------- 834
            ..|.|      :.|.:|   ||...:::..:|.| :.:|......|:|..||.:
Human   815 KRHYEEKQKEHLDTLNK---KKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQ 876

  Fly   835 -------------------SEAISSYQGLQNEVKQLEEGIQ----------ESVNQAKSI-ESGM 869
                               .||..:|..|.::|:.|::.|:          ::..|.:|. :...
Human   877 KIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRSFRQKNK 941

  Fly   870 SNLY---DKWEPKLNSLVETISTKFSEFMESIEYVGEVVLSKTDKYDFDSYGIQIMVQFRRGLQL 931
            .|||   :.::  :..|.......|...:....|.|::      .:|..:..:.|.||...|.:.
Human   942 PNLYYYINLFQ--MQCLTLRCKLYFDNLLSQRAYCGKM------NFDHKNETLSISVQPGEGNKA 998

  Fly   932 QPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHGSAQ 996
            ...|....|||||:.|...:.|||..:...||||:||.:..||..|.|...||:||.|......|
Human   999 AFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQ 1063

  Fly   997 YLFVTP---------KLLRDLNYNE 1012
            ::.:||         ||:|.|..::
Human  1064 FILLTPQSMSSLPSSKLIRILRMSD 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	44/164 (27%)
		Smc	22..1011	CDD:224117	255/1184 (22%)
		GrpE	212..>316	CDD:295646	20/105 (19%)
		ABC_SMC5_euk	<919..1025	CDD:213244	36/103 (35%)
SMC6	XP_011531409.1	Smc	48..1088	CDD:224117	257/1191 (22%)
		ABC_SMC6_euk	48..>204	CDD:213243	44/172 (26%)
		Fib_alpha	<662..742	CDD:285864	17/91 (19%)
		DUF5098	701..>835	CDD:293628	34/159 (21%)
		ABC_SMC6_euk	<996..1094	CDD:213243	32/93 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810