DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC5 and Smc4

DIOPT Version :9

Sequence 1:NP_996141.2 Gene:SMC5 / 326215 FlyBaseID:FBgn0052438 Length:1034 Species:Drosophila melanogaster
Sequence 2:NP_598547.1 Gene:Smc4 / 70099 MGIID:1917349 Length:1286 Species:Mus musculus


Alignment Length:1285 Identity:257/1285 - (20%)
Similarity:453/1285 - (35%) Gaps:395/1285 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ALSSKQLAGR--IHSVYCKDFVSYS-EITFHPKH-YLNVLTGPNGSGKSTIVSAIILGLGGEPIL 66
            |::|:..|.|  |..:..::|.||: |....|.| ..:.:.||||||||.::.:::...|..   
Mouse    70 AMASEAGAPRLMITHIVNQNFKSYAGEKVLGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYR--- 131

  Fly    67 LDRSASVADYIQSNKTSATI------------IVRV------------YGRTPNTTETFRRIINS 107
                   |..|:|.|.|..|            .|.|            |...||:.....|....
Mouse   132 -------AQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVLPNSNFYVSRTAYR 189

  Fly   108 NGLSTFSVNDKDTSKKNFLAAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQ--------------- 157
            :..|.:.::.|..:.|:....:.|..|.:.:....:.|..|:..:.|.|:               
Mouse   190 DSTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLED 254

  Fly   158 ------------------ELL-------LNTMSSVCDE--------------------------- 170
                              |:|       ||.:..|..|                           
Mouse   255 IIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEMFKKKNH 319

  Fly   171 -------DLINSFNSLKQMR----------TEQANVHANREKEKSDLVKK-QKRLEHLQMTVSQY 217
                   ||.|....:...:          ||::||.:|..|.|:..||. :|:|..:...:.|.
Mouse   320 ICQYYIYDLQNRIAEITTQKEKIHEDTKEITEKSNVLSNEMKAKNSAVKDVEKKLNKVTKFIEQN 384

  Fly   218 KER--------EEVKQKLQ--VYSAKKLWVETQAGEAKAAEMKTQVKNAKTQSDKLKNQHDKLLQ 272
            ||:        .:|::||:  ...||||..:.|..:.|..|:|:....:||..::...:::.|  
Mouse   385 KEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEELKSVPAKSKTVINETTTRNNSL-- 447

  Fly   273 SQEQIEKEKESLRKALLEKTRLLENAVAEKAAIDGKMDSLK---QGIYQKKYELEQNIKKSRRTA 334
                 |||:|...|.|.|                 .|||||   ||:.::|...|:.:....::.
Mouse   448 -----EKEREKEEKKLKE-----------------VMDSLKQETQGLQKEKEIQEKELMGFNKSV 490

  Fly   335 TECDNLNQLVENKIYELETLNKSRPLIVSELERAKESCAAARGKAMEQYSRRRQLEQKL------ 393
            .|..:..::.::   ||:.........||:|.:|||:...|.....|:.:..:.:..||      
Mouse   491 NEARSKMEVAQS---ELDIYLSRHNTAVSQLSKAKEALITASETLKERKAAIKDINTKLPQTQQE 552

  Fly   394 ---NDEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMNWLAQNKQRYKLNVYDPMILEL 455
               .::.:.::|..::.::.|.:...||::|.::.          ||.|:.|.|       :|:.
Mouse   553 LKEKEKELQKLTQEEINLKSLVHDLFQKVEEAKSS----------LAMNRSRGK-------VLDA 600

  Fly   456 TVQNHEDAKF---------LENVVAQRDLFAFACEDKGD--MSDLIN--ELCV----KQKLGVNV 503
            .:|..:..:.         |..:..:.|:...:|....|  :.|.|:  :.||    |..:|: .
Mouse   601 IIQEKKSGRIPGIYGRLGDLGAIDEKYDIAISSCCHALDYIVVDSIDTAQECVNFLKKHNIGI-A 664

  Fly   504 IYCAPSDRLVYSPK-----TPIDDLRSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGTEAVG 563
            .:.......|::.|     ||.:..|.|       |||......|.:  |.|    ..:....|.
Mouse   665 TFIGLDKMTVWAKKMSKIQTPENTPRLF-------DLVKVKNEEIRQ--AFY----FALRDTLVA 716

  Fly   564 NYTSSIPKAIRVYF------------------------GGSKKFVVTASRYRSDTILTESSIRAK 604
            |   ::.:|.||.:                        ||||   |...|..| :::.|.|:...
Mouse   717 N---NLDQATRVAYQRDRRWRVVTLQGQIIEQSGTMSGGGSK---VMRGRMGS-SVIDEISVEEV 774

  Fly   605 NQL-------------------------------------------------------------- 607
            |::                                                              
Mouse   775 NKMESQLERHSKQAMQIQEQKVQHEEAVVKLRHSERDMRNTLEKFAASIQGLSEQEEYLCVQIKE 839

  Fly   608 -----ITV--DSQQLALVMKQCSEAVKESDSIKNAITQTDNEFERLQAVAKDEQEKRRKLDQKIA 665
                 :|.  |.:|..|:.:..|...||.|::.....:.:.|.:||.....|...::.|..|   
Mouse   840 LEANVLTTAPDRKQQKLLEENVSVFKKEYDAVAEKAGKVEAEIKRLHNTIIDINNRKLKAQQ--- 901

  Fly   666 HFNSLKTEIETLQKKLE-----------ALRNSD-SLDCLETNFCNSLHKDL----KKIFDADAE 714
                  .:::|:.|:|:           |::.:| :|...:.:.|.: .|::    |:|.|...|
Mouse   902 ------NKLDTINKQLDECASAITKAQVAIKTADRNLKKAQDSVCRT-EKEIKDTEKEINDLKTE 959

  Fly   715 LCSCLKAIDRLIIEKNMAQTKVSIYMLQHETQIEALKESEEQSKAATRDFQQL---LQCLENQIS 776
            |.:.....:.:|.....|:|.:.....:|...::.||..:|...|..:|...:   |:.::..||
Mouse   960 LKNIEDKAEEVINNTKTAETSLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIS 1024

  Fly   777 DVN-------KRKSAIQGLCHGEIPTSSKFPFKKEFRELENIDLPE-LREAIHDFQARLECMKSV 833
            :.|       |..|.|:.....:.|..:.....:|  |||.|..|| :...|...:|:...||. 
Mouse  1025 EHNSKIKYWQKEISKIKLHPVEDNPVETVAVLSQE--ELEAIKNPESITNEIALLEAQCREMKP- 1086

  Fly   834 NSEAISSYQGLQNEVKQLEEGIQESVNQAKSIESGMSNLYDKWE----PKLNSLVE---TISTKF 891
            |..||:.|       |:.|:...:.|.:...|.|...|....:|    .:||..:.   .|:.|.
Mouse  1087 NLGAIAEY-------KKKEDLYLQRVAELDKITSERDNFRQAYEDLRKQRLNEFMAGFYVITNKL 1144

  Fly   892 SEFMESIEYVGEVVLSKTDKYDFDSYGIQIMVQFRRGLQLQPLDK-----FIQSGGERAVSIAIY 951
            .|..:.:...|:..|...|..|..|.||...|        :|..|     |..||||:.:|....
Mouse  1145 KENYQMLTLGGDAELELVDSLDPFSEGIMFSV--------RPPKKSWKKIFNLSGGEKTLSSLAL 1201

  Fly   952 SLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVT 1001
            ..:|.|....|...:|||:..:|..|. .|....:.|.||  :||::.::
Mouse  1202 VFALHHYKPTPLYFMDEIDAALDFKNV-SIVAFYIYEQTK--NAQFIIIS 1248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC5NP_996141.2 ABC_SMC5_euk 14..>160 CDD:213244 39/206 (19%)
Smc 22..1011 CDD:224117 252/1267 (20%)
GrpE 212..>316 CDD:295646 30/116 (26%)
ABC_SMC5_euk <919..1025 CDD:213244 24/88 (27%)
Smc4NP_598547.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51
SMC_N 81..1272 CDD:308206 253/1274 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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