DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC5 and Smc1a

DIOPT Version :9

Sequence 1:	NP_996141.2	Gene:	SMC5 / 326215	FlyBaseID:	FBgn0052438	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_113871.2	Gene:	Smc1a / 63996	RGDID:	61991	Length:	1233	Species:	Rattus norvegicus

Alignment Length:	1253	Identity:	241/1253 - (19%)
Similarity:	474/1253 - (37%)	Gaps:	351/1253 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GRIHSVYCKDFVSY-SEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYI 77
            |.:..:..::|.|| ......|......:.||||||||.::.||...||.:...| |..::.|.|
  Rat     2 GFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNL-RVKTLRDLI 65

  Fly    78 QS---NKTSA--TIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFLAAVSSFNIQVS 137
            ..   .|.:|  ..:..||........||.|:| ..|.|.:.:|:|......:...:....|.:.
  Rat    66 HGAPVGKPAANRAFVSMVYSEEGAEDRTFARVI-VGGSSEYKINNKVVQLHEYSEELEKLGILIK 129

  Fly   138 --NLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANVHANREKEKSDL 200
              |...|  |..|:..:..||:|     .:::.:|  |:....|.|          ..:|.|.::
  Rat   130 ARNFLVF--QGAVESIAMKNPKE-----RTALFEE--ISRSGELAQ----------EYDKRKKEM 175

  Fly   201 VKKQKRLE---HLQMTVSQYKEREEVKQ--------------------KLQVYSAKKLWVETQAG 242
            ||.::..:   |.:..::  .||:|.||                    :||::......||.:..
  Rat   176 VKAEEDTQFNYHRKKNIA--AERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKL 238

  Fly   243 EAKAAEMKTQVKNAKTQSDKL-------KNQHDKLLQSQEQIEKE------------------KE 282
            ..:.|....:::..|.:.||:       |.:..|:::.|:|||||                  ||
  Rat   239 NKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKE 303

  Fly   283 SLR---KALLEKTRLLENAVAEKAAIDGKMDSLKQGI---------YQKKYE-----------LE 324
            :..   |.|....:.|:||........|.||.|::.:         ::::.|           ||
  Rat   304 NTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLE 368

  Fly   325 QN-IKK--------SRRTAT---ECDNLNQ----------LVENKIYELETLNKSRPLIVSELER 367
            :| :||        |:|.||   |.:..|:          |.|.|..|.|...|.:   :.|:|.
  Rat   369 ENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQK---LREIEE 430

  Fly   368 AKESCAAARGKAMEQY--SRRRQLEQ--KLNDEMIPEITAYKLKIERLR---NVKMQKIDEIR-- 423
            .::     |.:.:|:|  :.::.||:  ||..|:..|:...|.:|:.:.   |..|:::.:.|
  Rat   431 NQK-----RIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARID 490

  Fly   424 ----AKNPNLVVAMNWLAQNKQRYKLNVYDPMI--LELTVQNHE-----------DAKFLENVVA 471
                ::.......|..:   |:.|..:||..:|  .:.|.:.::           ||..:::...
  Rat   491 RQESSRQQRKAEIMESI---KRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKT 552

  Fly   472 QRDLFAFACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVDLV 536
            .||...:..|.:|:....:                 |.|.|...|..  :.||.......::|::
  Rat   553 GRDCIQYIKEQRGEPETFL-----------------PLDYLEVKPTD--EKLRELKGAKLVIDVI 598

  Fly   537 TGPIPLINKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGGSKKFVVTA---SRYRSDTILT- 597
            ....|.|.| ...|:..|..:        ..::..|.|:.|||.::....|   :.::...:::
  Rat   599 RYEPPHIKK-ALQYACGNALV--------CDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISG 654

  Fly   598 -ESSIRAKNQ--------LITVDSQQLALVMKQCSEAVKESDSIKNA------------ITQTDN 641
             .|.::||.:        .:....::|...:|:..:|.::...::..            .:|:|.
  Rat   655 GASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDL 719

  Fly   642 EFERLQAVAKDEQEKRRKLDQKIAHF----NSLKTEIETLQKKLEALRNSDSLDCLE----TNFC 698
            |..:.:.:|.:.||| .||:.::|:|    |.:|..|::.:::::.|:  :.::.:|    ..||
  Rat   720 EQTKTRHLALNLQEK-SKLESELANFGPRINDIKRIIQSREREMKDLK--EKMNQVEDEVFEEFC 781

  Fly   699 NSLHKDLKKIFDADAELCSCLKAIDR---------------LIIEKNMA---QTKVSIY---MLQ 742
            ..:  .::.|.:.:.|.......|.:               |..|||..   |.||.::   :.:
  Rat   782 REI--GVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKK 844

  Fly   743 HETQIEALKESEEQSKAATRDFQQLLQCLENQ-------ISDVNKRKSAIQGLCHG--------- 791
            .|.:||.||:.|::......:....||.|:||       ::|.|.....|:....|
  Rat   845 DENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQ 909

  Fly   792 -EIPT-SSKFPFKKEFR-------ELENIDLPELREAIHDF-------QARLECMKSVNSEAISS 840
             |:.. .:|...|:..|       ::::|.||..:..:.|.       |.......|..:.:|.:
  Rat   910 KEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGGSQGEESVSGSQRTSSIYA 974

  Fly   841 YQGL-----------------QNEVKQLEEGIQESVNQAKSIESGMSNLYDKWEPKLNSL--VET 886
            .:.|                 :.|:||....:|:.:|:.:|:...::      .|.:.::  :|:
  Rat   975 REALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIA------APNMKAMEKLES 1033

  Fly   887 ISTKFSEFMESIEYV-----------GEVVLSKTDKYD--FDSYGIQIMVQFRR----------- 927
            :..||.|..:..|..           .::...:.|:::  |:|....|...::.
  Rat  1034 VRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFL 1098

  Fly   928 --------------------GLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQG 972
                                |.:.:|:|..  ||||:.|:......::......||..:|||:..
  Rat  1099 GPENPEEPYLDGINYNCVAPGKRFRPMDNL--SGGEKTVAALALLFAIHSYKPAPFFVLDEIDAA 1161

  Fly   973 MDATNERHIFDLLLKEAT 990
            :|.||...:.:.:.:::|
  Rat  1162 LDNTNIGKVANYIKEQST 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	41/153 (27%)
		Smc	22..1011	CDD:224117	240/1245 (19%)
		GrpE	212..>316	CDD:295646	32/151 (21%)
		ABC_SMC5_euk	<919..1025	CDD:213244	18/103 (17%)
Smc1a	NP_113871.2	SMC_N	3..1210	CDD:308206	240/1252 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..307		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..369		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..969		3/22 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900