DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC5 and smc1a

DIOPT Version :9

Sequence 1:	NP_996141.2	Gene:	SMC5 / 326215	FlyBaseID:	FBgn0052438	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_001155103.1	Gene:	smc1a / 559665	ZFINID:	ZDB-GENE-090506-9	Length:	1232	Species:	Danio rerio

Alignment Length:	1257	Identity:	250/1257 - (19%)
Similarity:	459/1257 - (36%)	Gaps:	385/1257 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GRIHSVYCKDFVSY-SEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYI 77
            |.:..:..::|.|| ......|.|....:.||||||||.::.||...|..:...| |..::.|.|
Zfish     2 GYLKLIEIENFKSYKGRQIIGPFHKFTAIIGPNGSGKSNLMDAISFVLAEKTSNL-RVKTLKDLI 65

  Fly    78 QS---NKTSA--TIIVRVYGRTPNTTETF-RRIINSNGLSTFSVNDKDTSKKNFLAAVSSFNIQV 136
            ..   .|.:|  ..:..||........|| |.||.|:  |.:.:|.|.....::...:....|.:
Zfish    66 HGAPVGKPAANRAFVSMVYCEDNGEECTFTRAIIGSS--SEYRINSKVVGLSDYSEELEKLGILI 128

  Fly   137 S--NLCQFLPQDRVQDFSKMNPQE--LLLNTMSS----------------VCDEDLINSFNSLKQ 181
            .  |...|  |..|:..:..||:|  .|...:|.                ..:||...|::..|.
Zfish   129 KARNFLVF--QGAVESIAMKNPKERTALFEEISRSGELAQEYDRRKKEMVKAEEDTQFSYHRKKN 191

  Fly   182 MRTEQANVHANREKEKSDLVKKQKRLE------HLQMTVSQ-YKEREEVKQKLQVYS-------- 231
            :..|:.  .|.:|||:::   :.:||:      |:|:.:.: |...||:::..:..|
Zfish   192 IAAERK--EAKQEKEEAE---RYQRLKDEVVRAHVQLQLFKLYHNEEEIEKLNRELSQRNREIDK 251

  Fly   232 -AKKL-WVETQAGEAKAAEMKTQVKNAKTQSDKLKNQHDKLLQSQEQIEKEKES----------L 284
             .||: .||.:..: |..|:...:::.:....::|.:..:|.|.:.|..|.||:          .
Zfish   252 DRKKMDHVEEELKD-KKKELGRMMRDQQNVEKEIKEKDAELNQKRPQYIKAKENTAHKIKKLEVA 315

  Fly   285 RKALLEKTRLLENAVAEKAAID---GKMDSLKQGIYQKKYE----------LEQNIKK------- 329
            ||:|....::.:...|:...:|   |.::..:|...::..|          ||:|..|
Zfish   316 RKSLQNAQKMYKKRKADIEELDREQGAVEMSRQEFEERMEEEAQSQGQDLTLEENQVKQYHRLKE 380

  Fly   330 --SRRTAT---ECDNLNQ----------LVENKIYELETLNKSRPLIVSE----LERAKESCAAA 375
              |:|.||   |.:..|:          |.|.|..|.|...|.:...:.|    :|:.::..|.:
Zfish   381 EASKRAATLAQELEKFNRDQKADQDRLDLEERKKIETEAKIKQKIREIEENQKRIEKLEDYIATS 445

  Fly   376 RGKAMEQYSRRRQLEQKLNDEM------IPEITAY---------KLKIERLRNVKMQKIDEIRAK 425
            |....||    |::|::|.:|:      |.||...         ..:|:|..|.:.|:..||
Zfish   446 RQSLDEQ----RRMEEELTEEVELAKRRIDEINMELNQVMEQLGDARIDRQENSRQQRKAEI--- 503

  Fly   426 NPNLVVAMNWLAQNKQRYKLNVYDPMI--LELTVQNHE-----------DAKFLENVVAQRDLFA 477
                      :...|:.|..:||..:|  .:.|.:.::           ||..:::....||...
Zfish   504 ----------MESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQ 558

  Fly   478 FACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVDLVTGPIPL 542
            :..|.:|:....:                 |.|.|...|..  :.||.......::|::....|.
Zfish   559 YIKEQRGEPETFL-----------------PLDYLEVKPTD--EKLRELRGAKLVIDVIRYEPPH 604

  Fly   543 INKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGGSKKFVVTASRYRSDTILTESSIRAKNQL 607
            |.| ...|:..|..:        ..::..|.|:.|||.         ||..|:..:.::..|:.:
Zfish   605 IKK-ALQYACGNALV--------CENVEDARRIAFGGP---------YRHKTVALDGTLFQKSGV 651

  Fly   608 ITVDSQQLALVMKQCSEAVKESDSIKNAITQTDNEF-ERLQAVAKD------------------- 652
            |:..:..|....::..|  |..|.:|....:...|. |:::|..|:
Zfish   652 ISGGASDLKAKARRWDE--KAVDKLKEKKEKLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKY 714

  Fly   653 -----EQEKRR----------KLDQKIAHF----NSLKTEIETLQKKLEALRNSDSLDCLET--- 695
                 ||.|.|          ||:.::|:|    |.:|..|::.::.:..||  |.::.:|.
Zfish   715 SQSDLEQTKTRHLSLNMQEKSKLESELANFGPRINDIKRIIQSRERDITQLR--DRMNLVEDEVF 777

  Fly   696 -NFCNSLHKDLKKIFDADAELCSCLKAI-----------DRLII----EKNMA---QTKVSIY-- 739
             .||..:  .::.|.:.:.|.......|           .||.|    |||..   |.||.::
Zfish   778 FEFCKEI--GVRNIREFEEEKVKRQNEIAKKRLEFETQKTRLAIQLDYEKNQLKEDQEKVMMWEQ 840

  Fly   740 -MLQHETQIEALKESEEQSKAATRDFQQLLQCLENQISDVNKRKSAIQGLCHGEIPTSSKFPFKK 803
             :.:.|.:||.||:.|.:......:....||.|:||  .:.|:         ||:...:
Zfish   841 TVKKDENEIERLKKEEHRHMKIIDETMAQLQDLKNQ--HLTKK---------GEVNDKN------ 888

  Fly   804 EFRELENI---------DLPELREAIHDFQARLECMKSVNSEAISSYQ----------GLQNEVK 849
              ||:|.|         :|.:|::.:...:.:||..:|.....:.:.:          |..:::.
Zfish   889 --REMEEIRKKLGSANKELTQLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLKSGTMDDIS 951

  Fly   850 QLEEG--IQESVNQAKS----------IESGMSNLYDKWEPKLN-------------------SL 883
            |.|.|  ::::::..|:          ||...|||.:..:..|:                   |:
Zfish   952 QGEGGSQVEDAISSPKASSSVHAKEALIEIDYSNLNEDLKDALSEDEIKGEMNTLQQRLNEQQSI 1016

  Fly   884 VETISTKFSEFMESIEYVGEVVLSKTDKYD---------------------------FDSYGIQI 921
            ::.||....:.||.:|.|.:.....:|:::                           |:|....|
Zfish  1017 LQRISAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNI 1081

  Fly   922 MVQFRR-------------------------------GLQLQPLDKFIQSGGERAVSIAIYSLSL 955
            ...::.                               |.:.:|:|..  ||||:.|:......::
Zfish  1082 DEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNL--SGGEKTVAALALLFAI 1144

  Fly   956 QHVTHVPFRCVDEINQGMDATN 977
            ......||..:|||:..:|.||
Zfish  1145 HSYKPAPFFVLDEIDAALDNTN 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	42/156 (27%)
		Smc	22..1011	CDD:224117	249/1249 (20%)
		GrpE	212..>316	CDD:295646	24/127 (19%)
		ABC_SMC5_euk	<919..1025	CDD:213244	17/90 (19%)
smc1a	NP_001155103.1	SMC_N	3..1208	CDD:280601	249/1256 (20%)
		ABC_SMC1_euk	4..>148	CDD:213242	38/148 (26%)
		SMC_hinge	513..628	CDD:214944	23/142 (16%)
		ABC_SMC1_euk	<1117..1220	CDD:213242	16/52 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900