DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC5 and smc1al

DIOPT Version :9

Sequence 1:	NP_996141.2	Gene:	SMC5 / 326215	FlyBaseID:	FBgn0052438	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_997975.2	Gene:	smc1al / 403060	ZFINID:	ZDB-GENE-040426-57	Length:	1233	Species:	Danio rerio

Alignment Length:	1241	Identity:	256/1241 - (20%)
Similarity:	463/1241 - (37%)	Gaps:	352/1241 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GRIHSVYCKDFVSY-SEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYI 77
            |.:..:..::|.|| ......|.|....:.||||||||.::.||...|..:...| |..::.|.|
Zfish     2 GYLKLIEIENFKSYKGRQIIGPFHKFTAIIGPNGSGKSNLMDAISFVLAEKTSNL-RVKTLKDLI 65

  Fly    78 QS---NKTSA--TIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFLAAVSSFNIQVS 137
            ..   .|.:|  ..:..||.:......:|.|||..:. |.:.:|:|.....::...:....|.:.
Zfish    66 HGAPVGKPAANRAFVTMVYQQDGGQELSFSRIIIGSS-SEYRINNKVVGLSDYSEELEKLGILIK 129

  Fly   138 --NLCQFLPQDRVQDFSKMNPQE--LLLNTMS---------SVCDEDLINS-----FN------- 177
              |...|  |..|:..:..||:|  .|...:|         ..|.::::.:     ||
Zfish   130 ARNFLVF--QGAVESIAMKNPKERTALFEEISRSGELAQEYDRCKKEMVKAEEDTQFNYHRKKNI 192

  Fly   178 -----SLKQMRTE------------QANV----------------------HANREKEK------ 197
                 ..||.:.|            :|:|                      |.|:|.:|
Zfish   193 AAERKEAKQEKEEAERYQRLKDEVVRAHVQLQLFKLYHNESEIEKLNRELAHRNKEIDKDRKRMD 257

  Fly   198 ---SDLVKKQKRLEHL----QMTVSQYKERE-EVKQKLQVYSAKKLWVETQAGEAKAAE-MKTQV 253
               .:|..|:|.|..:    ||...:.||:: |:.||..:|...|   |..|.:.|..| .:..:
Zfish   258 RVEEELKDKKKELGRMMRDQQMIEKEIKEKDAELNQKRPLYIKAK---ENTAHKIKKLEAARKSL 319

  Fly   254 KNAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLEKT-------RLLENAVAEKAAIDGKMDS 311
            :||:....|.|...|:|.:.|..:|..::...:.:.|:.       :|.||.|  ||     ...
Zfish   320 QNAQKCYKKRKGDMDELDREQGAVEMARQEFEERMEEEAQSQGQDLQLEENQV--KA-----YHR 377

  Fly   312 LKQGIYQKKYELEQNIKKSRRTATECDNLNQLVENKIYELETLNKSRPLIVSELERAKESCAAAR 376
            ||:...::...|.|.::|..|......:...|.|.|..|.|...|.:   :.|:|..::     |
Zfish   378 LKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKIETEAKIKQK---IREIEENQK-----R 434

  Fly   377 GKAMEQY---SRRRQLEQK-LNDEMIPEITAYKLKIERLRNVKMQKIDE-------IRAKNPNLV 430
            .:.:|.|   ||:...||| :.:|:..|:...|.:|:.: |:::.::.|       .|.:|....
Zfish   435 IEKLEDYITTSRQSLDEQKRMEEELTEEVEQAKRRIDEI-NMELNQVMEQLGDARIDRQENSRQQ 498

  Fly   431 VAMNWLAQNKQRYKLNVYDPMI--LELTVQNHE-----------DAKFLENVVAQRDLFAFACED 482
            .....|...|:.|..:||..:|  .:.|.:.::           ||..:::....||...:..|.
Zfish   499 RKAEILESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQ 563

  Fly   483 KGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVDLVTGPIPLINKLC 547
            :|:....:                 |.|.|...|..  :.||.......::|::....|.|.| .
Zfish   564 RGEPETFL-----------------PLDYLEVKPTD--EKLRELRGAKLVIDVIRYEPPQIKK-A 608

  Fly   548 ASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGGSKKFVVTASRYRSDTILTESSIRAKNQLITVDS 612
            ..|:..|..:        ..::..|.|:.|||.         ||..|:..:.::..|:.:|:..:
Zfish   609 LQYACGNALV--------CDNVEDARRIAFGGP---------YRHKTVALDGTLFQKSGVISGGA 656

  Fly   613 QQLALVMKQCSEAVKESDSIKNAITQ-TDNEFERLQAVAKD------------------------ 652
            ..|....::..|  |..|.:|:...: ||...|:::|..|:
Zfish   657 SDLKAKARRWDE--KAVDKLKDRKEKLTDELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDL 719

  Fly   653 EQEKRR----------KLDQKIAHF----NSLKTEIETLQKKLEALRNSDSLDCLE----TNFCN 699
            ||.|.|          ||:.::|:|    |.:|..|::.::.::.|:  |.::.:|    ..||.
Zfish   720 EQTKTRHLSLNMQEKSKLESELANFGPRINDIKRIIQSRERDMKDLK--DRMNVVEDEVFVEFCK 782

  Fly   700 SLHKDLKKIFDADAELCSCLKAI-----------DRLII----EKNMA---QTKVSIY---MLQH 743
            .:  .::.|.:.:.|.......|           .||.|    |||..   |.||.::   :.:.
Zfish   783 EI--GVRNIREFEEEKVKRQNEIAKKRLEFETQKTRLAIQLDYEKNQLKEDQEKVVMWEQTVKKD 845

  Fly   744 ETQIEALKESEEQSKAATRDFQQLLQCLENQ-------ISDVNKRKSAIQ---GLCHGEI----- 793
            |.:||.||:.|:::.....:....||.|:||       ::|.|.....|:   |..:.|:
Zfish   846 ENEIEKLKKEEQRNMKIIDETMAQLQDLKNQHLTKKSEVNDKNHEMEEIRKKLGGANKELTQLQK 910

  Fly   794 ---PTSSKFPFKKEFR-------ELENIDLPELREAIHDFQARLECMKSVNSEAISSYQGLQNEV 848
               ...:|...|:..|       ::::|.|| ||....|..::.| ..|...|::||.|...:.|
Zfish   911 EVTAIETKLEQKRSDRHNLLQACKMQDIKLP-LRSGTMDDISQEE-GNSQAEESLSSSQKTSSTV 973

  Fly   849 -----------KQLEEGIQESVNQAKSIESGMSNLYDKWEPKLN---SLVETISTKFSEFMESIE 899
                       ..|.|.:::|::. :.|::.|:.|    :.:||   |:::.||....:.||.:|
Zfish   974 LAKEALIEIDYNSLSEDLKDSLSD-EEIKAEMNTL----QQRLNEQQSILQRISAPNMKAMEKLE 1033

  Fly   900 YVGEVVLSKTDKYD---------------------------FDSYGIQIMVQFRR---------- 927
            .|.:.....:|:::                           |:|....|...::.
Zfish  1034 SVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFHACFESVATNIDEIYKALSRNSSAQAF 1098

  Fly   928 ---------------------GLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQ 971
                                 |.:.:|:|..  ||||:.|:......::......||..:|||:.
Zfish  1099 LGPENPEEPYLDGINYNCVAPGKRFRPMDNL--SGGEKTVAALALLFAIHSYKPAPFFVLDEIDA 1161

  Fly   972 GMDATN 977
            .:|.||
Zfish  1162 ALDNTN 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	40/155 (26%)
		Smc	22..1011	CDD:224117	255/1233 (21%)
		GrpE	212..>316	CDD:295646	29/112 (26%)
		ABC_SMC5_euk	<919..1025	CDD:213244	17/90 (19%)
smc1al	NP_997975.2	SMC_N	3..1209	CDD:280601	255/1240 (21%)
		ABC_SMC1_euk	4..>148	CDD:213242	36/147 (24%)
		SMC_hinge	513..628	CDD:214944	23/142 (16%)
		ABC_SMC1_euk	<1118..1221	CDD:213242	16/52 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900