Protein Alignment SMC5 and SMC2

DIOPT Version :9

• Sequence 1: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Alignment Length: 1252
• Identity: 250/1252 - (19%)
• Similarity: 448/1252 - (35%)
• Gaps: 377/1252 - (30%)

  Fly    24 FVSYSEIT----FHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYI----QSN 80
            |.||...|    |.|:  ...:||.||||||.|:.:|...||...:...|::::.|.:    |:.
  Fly    11 FKSYGRRTEIEGFDPE--FTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNGQAG 73

  Fly    81 KTSATIIVRVYGRT-----PNTTETFRRI-----INSNGLSTFSVNDKDTSKKNFLAAVSSFNIQ 135
            .|.||:.: |:..|     |...|..|.|     :...|.:.|.:|.|....|.......|..:.
  Fly    74 ITKATVTI-VFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDFFCSIQLN 137

  Fly   136 VSNLCQFLPQDRVQDFSKMNPQELL------LNTMSSVCDEDLINSFNSLKQMRTEQANVHANRE 194
            |:|....:.|.::|....|.|:|:|      ..|.......|...:....|:.:..:..|..:.|
  Fly   138 VNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETKVLLDEE 202

  Fly   195 ---------KEKSDLVKKQKRLEHLQMTVSQYKEREEVKQ--KLQVYSAKKLWVETQAGEAKA-- 246
                     :|:|...:.||....:...:..:...:.:||  .|:...|.:..:|.:....||
  Fly   203 VLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKATH 267

  Fly   247 ----------------------AEMKTQVKNAKTQSDKLK----NQHDKLLQSQEQIEKEKESLR 285
                                  |||...:||.:||....:    .....|..:|..|:::::.:|
  Fly   268 AKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTIQQDEKKIR 332

  Fly   286 ---KALLEKTRLLENAVAEKAAIDGKMDSLKQGIYQKKYELEQNIKKSRRTATECDNLNQLVENK 347
               |.:.:..|.|....|:.|.:.|:.:|||:...:.....|...||....:      ..|..|:
  Fly   333 MASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVS------QGLSTNE 391

  Fly   348 IYELETLNKSRPLIVSELERAKESCAAARGKAMEQYSRRRQLEQ----------------KLNDE 396
            ..|..||.:.  |||:: |:..|:....:...:|....|..|:|                ||:|:
  Fly   392 NGEASTLQEQ--LIVAK-EQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQ 453

  Fly   397 MIPEITAYKLKIERLRNVKMQKID-------EIRAKNPNLVVAMNWLAQ-----NKQRYKLNVYD 449
            ::.||.    .:||    ::|.:|       :::.:..:|.:....|.:     |..||.|...|
  Fly   454 LVVEIK----NLER----QLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQD 510

  Fly   450 PMILELTVQNHEDAKFLENVVAQRDLFAFACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVY 514
            |       :.:.|.:.:..:|.:  ||        .:.|:.|.:.:.|..|.:          :|
  Fly   511 P-------EPNFDRRKVRGLVGK--LF--------QVKDMQNSMALVQTAGGS----------LY 548

  Fly   515 SPKTPIDDLRSFGF--RSYLVDLVTGPIPLINKLCASYSIHNI------PIGTEAVG------NY 565
            |..|. ||:.|...  |..|...|| .|| |||:.:.....|:      .:|.|.|.      :|
  Fly   549 SYVTD-DDVTSKKILQRGNLQRRVT-LIP-INKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDY 610

  Fly   566 TSSIPKAIRVYFGGSKKFVVTASRYRSDTILTESSIRAKNQLITVDSQQLALVMKQCSEAVKESD 630
            .......::..|||              |::.:..|.||.  |:.|.:      ..|.....|.|
  Fly   611 DRYYEPVMKFCFGG--------------TLICKDLIVAKQ--ISYDPR------INCRSVTLEGD 653

  Fly   631 SIK-------NAITQTDNEFERLQAVAKDEQEKRRKLDQKIAH--------------FNSLKTEI 674
            .:.       .|..:..|..|.|.|:.:.|:| .|::|.:||.              ||.:|..:
  Fly   654 VVDPHGTVSGGAAPKGANVLEELHAIKQIEKE-YREIDSEIAQVEKQIASIENQALAFNKMKENL 717

  Fly   675 ETLQKKLEALRN-----------------SDSLDCLETNFCNSLHK---DLKKIFDADAELCSCL 719
            :..|.:|....|                 .:.:..||....:|..|   ...||.|.:|:|....
  Fly   718 DLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAK 782

  Fly   720 KAIDRLIIEKNMAQTKVSIYMLQHETQIEALKESEEQSKAATRDFQQLLQCLENQISDVNKRKSA 784
            ...:|   |.|.|           ..:|:..|:..|:|:|..:..:|..:.|:.:|:::.|
  Fly   783 GYRER---ELNAA-----------TNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQK---- 829

  Fly   785 IQGLCHGEIPTSSKFPFKKEFRE-LENI-------------------DLPELREAIHDFQARL-- 827
                   .|.|:     ||:.:| ::|:                   ::.||.:||.:.:.:|
  Fly   830 -------SIETA-----KKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRD 882

  Fly   828 ------------ECMKSVNSEAISSYQGLQNEVKQLEEGIQESVNQAKSIES------------G 868
                        |.|...|.|.....:..:||.|::....:|:..:.:::|:            |
  Fly   883 QNKEMRNQLVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFG 947

  Fly   869 MSNL---YDKWEP---------------------------------------------------- 878
            |.|.   |.|.:|
  Fly   948 MKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEK 1012

  Fly   879 --------------KLNSLVETISTKFSEFMESIEYVGEVVLSKTDKYDFDSYGIQIMVQFRRGL 929
                          :||.....::|.||....|:....|..|:........: |::|.|.| .|:
  Fly  1013 IKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLT-GLEIKVGF-NGI 1075

  Fly   930 QLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHGS 994
            ..:.|.:.  |||::::......|::...:..|...:||::..:|.::.::|..:|.:..|   :
  Fly  1076 WKESLGEL--SGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFT---N 1135

  Fly   995 AQYLFVTPKLLRDLNYN 1011
            :|:|.|:   |:|..:|
  Fly  1136 SQFLIVS---LKDGLFN 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	43/153 (28%)
		Smc	22..1011	CDD:224117	249/1250 (20%)
		GrpE	212..>316	CDD:295646	27/136 (20%)
		ABC_SMC5_euk	<919..1025	CDD:213244	22/93 (24%)
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	250/1252 (20%)
		ABC_SMC2_euk	1..>170	CDD:213240	44/161 (27%)
		SMC_hinge	520..637	CDD:214944	34/155 (22%)
		V_Alix_like	690..933	CDD:187408	50/272 (18%)
		P-loop_NTPase	<1073..1167	CDD:304359	19/85 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810