DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC5 and smc2

DIOPT Version :9

Sequence 1:NP_996141.2 Gene:SMC5 / 326215 FlyBaseID:FBgn0052438 Length:1034 Species:Drosophila melanogaster
Sequence 2:NP_955836.2 Gene:smc2 / 321452 ZFINID:ZDB-GENE-030131-105 Length:1199 Species:Danio rerio


Alignment Length:1282 Identity:248/1282 - (19%)
Similarity:458/1282 - (35%) Gaps:432/1282 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 IHSVYCKDFVSYSEIT----FHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADY 76
            |.|:..:.|.||:|.|    |.|  :.|.:||.||||||.|:.:|...||...:...|:.::.|.
Zfish     3 IKSIVLEGFKSYAERTEINGFDP--FFNAITGLNGSGKSNILDSICFLLGISNLSQVRATNLQDL 65

  Fly    77 IQSNK----TSATIIVRVYGRTPNTTETFRRIINSNGLST---FSVNDKDT---------SKKNF 125
            :..|.    |.||:.:           ||.   |||...:   |..:|:.|         ..|..
Zfish    66 VYKNGLAGITKATVSI-----------TFD---NSNKKQSPLGFETHDEITITRQVVIGGRNKYL 116

  Fly   126 LAAVSSFNIQVSNL-CQ----------FLPQDRVQDFSKMNPQELL------------------- 160
            :..|::.|::|.:| |.          .:.|.|:.....|.|.|:|                   
Zfish   117 INGVNANNLRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILAMIEEAAGTRMYECKKISA 181

  Fly   161 ----------LNTMSSVCDEDLINSFNSLKQMRTEQANVHANREKEKSDLVKKQKRLEHLQMTVS 215
                      |..:.::.||::..:...||:.|....           :..|..:.:|||.....
Zfish   182 QKTIEKKDAKLKEIQTILDEEITPAMEKLKEERASYL-----------EYQKLMREIEHLSRLYV 235

  Fly   216 QY----------KEREEVKQKLQVYSAKKLWVETQAGEAKAAEMKTQVKNAKTQSDK-----LKN 265
            .|          |..||: |::| .|..||....:..|||..|:..:::..:.:.||     |:.
Zfish   236 AYLFVCAEETKLKSNEEL-QEMQ-SSIAKLQENMKQNEAKVKELSAEIQELERRRDKEVGGVLRT 298

  Fly   266 QHDKL-------LQSQEQIEKEKESLRKALLEKTRLLEN-----------------------AVA 300
            ..:.|       .::|..::.:|::|:....::..|::|                       ||.
Zfish   299 LEETLSEAQRVDTKAQSALDLKKQNLKDETKKRKELVKNMEEDKKVMSAKEAEVAKAVERLKAVK 363

  Fly   301 E------------------------------KAAIDGKMDSLKQGIYQKKYE----------LEQ 325
            |                              :|.:.|:|.:.|..|.:.:.|          .:|
Zfish   364 EEGQKDAEALEAAQQHFKAVSAGLSANEDGAEATLSGQMMTCKNDISKAETEAKQAQMKLKHAQQ 428

  Fly   326 NIKKSRRTATECDN-----------LNQLVENKIYELETLNKSRPLIVSELERAKESCAAARGKA 379
            .:|..:....:.|:           :|:.:|....|::.||         .|..:|.|.      
Zfish   429 ELKTKQAQVKKMDSGYKKDQDTFEAVNKCIEKLQAEMKKLN---------YEDGREECL------ 478

  Fly   380 MEQYSRRRQLEQK--LNDEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMNWLAQNKQR 442
                     ||||  .:.|:|....||:..:.:..|::.:..|..|          ||.....:.
Zfish   479 ---------LEQKRQFSREVIQLREAYESLMGQFPNLRFEYTDPER----------NWERSKVKG 524

  Fly   443 YKLNVYDPMILELTVQNHEDAKFLE--------NVVAQRDLFAFACEDKGDMSDL-----INELC 494
            ...|::       ||.:..:|..||        |||...::......:||::...     :|::.
Zfish   525 LVANLF-------TVTDVSNATALEVVAGGRLYNVVVDNEVTGKKLLEKGELRRRYTIIPLNKIS 582

  Fly   495 VKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGT 559
            .: .|..||:..|..                          :.||             .|:....
Zfish   583 AR-TLNDNVVRTAKK--------------------------LVGP-------------DNVHTAL 607

  Fly   560 EAVGNYTSSIPKAIRVYFGGSKKFVVTASRYRSDTILTESSIRAKNQLI---TVDSQ-------- 613
            ..|| |.|.:.||:...||.:   :|..|...:..:..:..:..|...:   ..|.|        
Zfish   608 SLVG-YESELRKAMEYVFGTT---LVCDSLDNAKKVAFDKGVSTKTVTLGGDVFDPQGTLTGGAR 668

  Fly   614 -QLALVMKQCSEAVKESDSIKN---AITQTDNEFERLQAVAKDEQEKRRKLDQKIAHFNSLKTEI 674
             |.|.|:.:.:|.....||::|   .::..::|...|:..|:..::.:::||.|......|:|::
Zfish   669 AQTASVLSKLAEVKDIQDSLRNKEAELSAVESELSGLKGTAEKYRQLKQQLDLKTEEARILETKL 733

  Fly   675 E-----TLQKKLEALRNSDSLDCLET------------NFCNSLHKDLKKIFDADAELCSCLKAI 722
            :     ..|::||.||.:.. :|.:|            ...|.|...:|   :|.||....|||.
Zfish   734 QQSSFHKQQEELENLRKTIE-ECEDTLQKTKEVQKKAEEKYNVLENKMK---NAAAEREKELKAA 794

  Fly   723 DRLIIEKNMAQTKVSIYM-----LQHET-----QIEALKES----EEQSKAATRDFQQLLQCLEN 773
            .:.:   |.|::|...:.     .|.|.     ::|.||..    |:|.:|.....:.:.:.::|
Zfish   795 QQKL---NQAKSKADAFSKRLKEKQQEADAVALELEELKREQAGYEQQIQAVDEALKAVQEQIDN 856

  Fly   774 QISDVNKRKSAIQGLCHGEIPTSSKFPFKKEF-----REL--ENIDLPELREAIHDFQARLECMK 831
            ..::|:..|.|::       ....|...:||.     ||:  ::.:...|||..:|.|.:::.::
Zfish   857 MTTEVSANKEAVR-------VAQEKLSQQKEVIMGQEREIKGKSGEANRLREQNNDAQLKIKELE 914

  Fly   832 ---------SVNSEA-----------ISSYQGLQNE------------------VKQLEE---GI 855
                     |.::.|           |||.:.|..:                  :|:|||   .:
Zfish   915 HNISKHKKDSADATAKVARMLAENDWISSEKHLFGQPNTAYDFKTNNPKEAGQRLKRLEETKDKL 979

  Fly   856 QESVN-QAKSIESGMSNLYDKWEPKLNSLVETISTKFSEFMESIEYVGEVVLS----KTDKYDFD 915
            :.:|| :|.::.|.....|:..:.| ..:||....|..|.:|.::......|:    |.:| ||.
Zfish   980 ERNVNRRAMNMLSEAEERYNDLKKK-KRIVENDKAKILETIEELDQKKNEALNVAWQKVNK-DFG 1042

  Fly   916 SY------------------GIQIMVQFRRGL------QLQPLDKFIQSGGERAVSIAIYSLSLQ 956
            |.                  |:...::|:..|      .|..|     |||:|::......|::.
Zfish  1043 SIFSTLLPGANARLAPPEGCGVLDGLEFKVALGNTWKENLTEL-----SGGQRSLVALSLILAML 1102

  Fly   957 HVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVTPK 1003
            .....|...:||::..:|.::.::|..:|   .|....:|::.|:.|
Zfish  1103 LFKPAPIYILDEVDAALDLSHTQNIGQML---RTHFTHSQFVVVSLK 1146

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC5NP_996141.2 ABC_SMC5_euk 14..>160 CDD:213244 47/174 (27%)
Smc 22..1011 CDD:224117 246/1276 (19%)
GrpE 212..>316 CDD:295646 29/178 (16%)
ABC_SMC5_euk <919..1025 CDD:213244 19/91 (21%)
smc2NP_955836.2 Smc 1..1170 CDD:224117 248/1282 (19%)
ABC_SMC2_euk 1..>156 CDD:213240 44/168 (26%)
L_lactis_ph-MCP 252..>465 CDD:115336 33/214 (15%)
SMC_hinge 522..639 CDD:214944 29/167 (17%)
DUF4200 740..841 CDD:290574 26/107 (24%)
P-loop_NTPase <1074..1169 CDD:304359 18/81 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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