Protein Alignment SMC5 and Smc6

DIOPT Version :9

• Sequence 1: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_001101484.1
• Gene: Smc6 / 313961
• RGDID: 1311214
• Length: 1097
• Species: Rattus norvegicus
• Alignment Length: 1142
• Identity: 235/1142 - (20%)
• Similarity: 449/1142 - (39%)
• Gaps: 240/1142 - (21%)

  Fly     3 GDRALSSKQLAGRIHSVYCKDFVSYSEI-TFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPIL 66
            |...|::.:: |.|.|:..::|:.:|.: .|.....:|.:.|.||||||.:::|:|:||||:.:.
  Rat    42 GTSTLTAAEV-GIIESIQLRNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGKAVA 105

  Fly    67 LDRSASVADYIQSNKTSATIIV------------RVYGRTPNTTETFRRIINSNGLSTFSVNDK- 118
            .:|.:|:..::::.:.||.|.:            .|||    .:...::.|:.:|..::.:..:
  Rat   106 TNRGSSLKGFVKAGQNSADISITLRNRGDDAFRANVYG----DSIVVQQHISVDGSRSYKLKSEK 166

  Fly   119 ----DTSKKNFLAAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSF--- 176
                .|.|:..:|.:..|||||.|....|.|:..:.|            :.|..:.|....|
  Rat   167 GTVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQF------------LQSKNEGDKYKFFMKA 219

  Fly   177 NSLKQMRTEQANVHANREKEKSDLVKKQKRLEHLQMTVSQYKER-------EEVKQKLQVYSAKK 234
            ..|:||:.:.:.:...:|:.|..:.:.::||..|:....:.:||       ..:|..|:....:.
  Rat   220 TQLEQMKEDYSYIMETKERTKEQINQGEERLTELKRQCLEKEERFQNIAGLSTMKTNLEYLKHEM 284

  Fly   235 LW-----VETQ---------AGEAKAAEMKTQVKNAKTQSDKLKNQHDKLLQSQEQIEKEKESLR 285
            .|     :|.|         .||.:||::..:::.   |..:|.:...|....|:::||..|...
  Rat   285 AWAVVNEIEKQLNAIRDNIKIGEERAAKLDRKMEE---QQVRLNDAEKKYKDIQDKLEKISEETN 346

  Fly   286 KALLEKTRLLENAVAEKAAIDGKMDSLKQGIYQKKYELEQNIKKSRRTATECDNLNQLVENKIYE 350
            ....|...|..:.:|...|.:.     .:.:|.:.....:.:||.....  |..:.:|.::....
  Rat   347 ARAPECMALKTDVIARTRAFND-----AEVLYNRSLNEYKALKKDGEQL--CKRIEELKKSTDQS 404

  Fly   351 LETLNKSRPLIVSELERAKESC-AAARGKAMEQYSRR-----RQLEQKLNDEMIPEITAYKLKIE 409
            ||.         ..|||.|..| ...:.||::.....     .|.||.:..:....:...:..:|
  Rat   405 LEP---------ERLERQKRICWLKEKVKALQDQENTVNQEVEQFEQAIEKDKQEHVRIKREDVE 460

  Fly   410 ----------RLRNVKMQKIDEIRAKNPNLVVAMNWL--AQNKQRYKLNVYDPMILELTVQNHED 462
                      :|:.:|..|.|.::...|::...:..:  |..::::......|:...:.:::.|.
  Rat   461 VRHTLSYNQRQLKELKDSKTDRLKRFGPHVPALLEAIDDAYRRRQFTHKPIGPLGACIHLRDPEL 525

  Fly   463 AKFLENVVAQRDLFAFACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFG 527
            |..:|:.: :..|.|:.|.:..| ..::..|..|                .|.|.|....:....
  Rat   526 ALAIESCL-KGLLQAYCCHNHAD-ERVLQSLMKK----------------FYPPGTSRPQIIVSE 572

  Fly   528 FRSYLVDLVTGPIPLINKLCASYS------IHNIPIGTEAVGNYTSSIPKAIRVYFGGSKKFVVT 586
            ||:.:.|:         :|.|:|.      :..:.|....|.|....:            :.:.|
  Rat   573 FRNEVYDV---------RLRAAYHPEFPTVLTALEIDNAVVANSLIDM------------RSIET 616

  Fly   587 ASRYRSDTI---LTESSIRAKN--QLITVDSQQLALVMKQCSEAVKE---SDSIKNAITQTDNEF 643
            ....:::::   :.:|....||  :..|.|..|:.......||:.:.   |..:.:.|:..:.|.
  Rat   617 VLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSESTRPKFLSRDVDSEISDLETEI 681

  Fly   644 E-----------RLQAVAKDEQEKRRKLDQKIAHFNSLKTEIETLQKKLEALRNSDSLDCLETNF 697
            |           ||.|:.||.:.....|.:...|:..:|.:|   :|.:..:|..::::
  Rat   682 ENKKGHIMNLQHRLSALEKDIKRNEELLKRCQLHYKEIKMKI---RKNISEIRELENIE------ 737

  Fly   698 CNSLHK--DLKKIFDADAELCSCLKAIDRLIIEKNMAQTKVSIYMLQHETQIEALKESEEQSKAA 760
               .|:  |:..:.|...|     ..|...::||||.|.|.::..|: ..:||| :...:..|..
  Rat   738 ---EHQSVDIATLEDEAEE-----NKIKMQMVEKNMEQQKENMENLK-TLKIEA-ENKYDTIKLK 792

  Fly   761 TRDFQQLLQCLENQI----SDVNKRKSAIQGLCHGEIPTSSKF-PFKKEFRELENIDLPELREAI 820
            .....:|...|::::    |:|:.:|   :|..|.|....... ...|:.|||: :...||:|.:
  Rat   793 INQLSELADPLKDELNLADSEVDSQK---RGKQHYEDKQKEHMDTLNKKRRELD-MKEKELQEKM 853

  Fly   821 HDFQARLECMKSVNSEAISSYQGLQNEVKQLEEGIQ----------ESVNQ-------------- 861
            .  |||..|.:.:  |...|...|..|:.:|.:.||          |.:.|
  Rat   854 S--QARQICPERI--EVKKSASILDKEINRLRQKIQAEHASHGDREEIMKQYQEARETYLDLDSK 914

  Fly   862 -------AKSIESGMSNLYDKWEPKLNSLVETISTKFSEFMESIEYVGEVVLSKTDKYDFDSYGI 919
                   .|.:|..|::.|..::.....|.......|...:....|.|::      .:|..:..:
  Rat   915 VRTLRRFIKLLEEIMTHRYKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKM------NFDHKNETL 973

  Fly   920 QIMVQFRRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDL 984
            .|.||...|.:....|....|||||:.|...:.|||..:...||||:||.:..||..|.|...|:
  Rat   974 SISVQPGEGNKASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDM 1038

  Fly   985 LLKEATKHGSAQYLFVTP---------KLLRDLNYNE 1012
            :||.|......|::.:||         ||:|.|..::
  Rat  1039 ILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSD 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	42/163 (26%)
		Smc	22..1011	CDD:224117	230/1120 (21%)
		GrpE	212..>316	CDD:295646	22/124 (18%)
		ABC_SMC5_euk	<919..1025	CDD:213244	35/103 (34%)
Smc6	NP_001101484.1	Smc	54..1075	CDD:224117	232/1127 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810