Protein Alignment SMC5 and Smc1b

DIOPT Version :9

• Sequence 1: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: XP_038934778.1
• Gene: Smc1b / 300121
• RGDID: 1308791
• Length: 1249
• Species: Rattus norvegicus
• Alignment Length: 1225
• Identity: 231/1225 - (18%)
• Similarity: 458/1225 - (37%)
• Gaps: 324/1225 - (26%)

  Fly    14 GRIHSVYCKDFVSY-SEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYI 77
            |.:..:..::|.|: ......|......:.||||||||.::.|:...:|.:...| |..::.:.|
  Rat     2 GHLELLLVENFKSWRGRQVIGPFKRFTCIIGPNGSGKSNVMDALSFVMGEKTTNL-RVKNIQELI 65

  Fly    78 Q--------SNKTSATIIVRVYGRTPNTTETFRRIINS-NGLSTFSVNDKDTSKKNFLAAVSSFN 133
            .        |:..|.|||   |.......:||.|||.. .|.|.|...||..|:..::|.:.:..
  Rat    66 HGAHIGKPVSSSASVTII---YVEDSGEEKTFTRIIRGRGGCSEFHFGDKPVSRSVYVAQLENIG 127

  Fly   134 IQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLK---QMRTEQANVHANREK 195
            |.|......:.|..|:..|...|:|............:.|..:.:.|   |...|.|..|.||:|
  Rat   128 IIVKAQNCLVFQGTVESISMKKPKERTQFFEEISTSGEFIGEYEAKKKKLQKAEEDAQFHFNRKK 192

  Fly   196 ----EKSDLVKKQKRLEHLQMTVSQYKEREEVK-QKLQV------YSAKKLWVETQAGEAKAAEM 249
                |:.....:::..||.|..:      ||:| .|:|:      |:.:|:.|..       .|:
  Rat   193 NVAAERKHAKIEKEEAEHYQSLL------EELKTNKIQLMLFQLYYNEEKINVLN-------TEL 244

  Fly   250 KTQVKNAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLEKTRLLENAVAEKAAIDGKMDSLKQ 314
            :...:|.....|.| :.|:.:::::   :|:...|       ||.|:....|..:::..::..:.
  Rat   245 EHMDRNLSVVKDTL-SHHENIIKAK---KKDYGML-------TRQLQQTAKELKSVEAVLNQKRP 298

  Fly   315 GIYQKKYELEQNIKK-----------SRRTATECDNLNQLVE------------NKIYELETLNK 356
            ...:.|.....::||           .::.|.:.|.:..||.            .|..|.:.|:|
  Rat   299 QYIKAKENTSHHLKKLDLSKKLITDNEKQCAKQEDGIRALVAELVDLDRAWRSFEKQMEEKILHK 363

  Fly   357 SRPLIV--SELERAKESCAAARGKA--MEQYSRRRQLEQKLNDEMI------------------P 399
            .|.:.:  |:|:|.||.....|.:.  |.|...:.|.|||...|.:                  .
  Rat   364 GRDIELENSQLDRYKELKEQVRRRVGIMTQQLEKLQWEQKAEKERLAFERRRHGDTQGNLKQIKE 428

  Fly   400 EITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMNWLAQNKQRY-----KLNVYDPMILELTVQN 459
            :|..:|.:||:|.......:|.:..|.......:..:...|.|.     :|::....:....:.|
  Rat   429 QIEEHKKRIEKLEEYTKTCMDCLEDKKQQEEALIKEIDNTKSRMSEVNEELSLIRNELQNAGIDN 493

  Fly   460 HED------AKFLENVVAQRDLFAFACEDKGDMSDLINELCVKQKLGVNVIY-------CAPSDR 511
            ||.      |:.||::........|     |.:.||.:.:..|.:|.|..::       ...|::
  Rat   494 HEGKRQRKRAEVLEHLKRLYPDSVF-----GRLLDLCHPIHKKYQLAVTKLFGRYMVAIVVASEK 553

  Fly   512 LV-----------YSPKT----------PIDD-LRSFGFRSYLVDLVTGPIPLINK----LCASY 550
            :.           ..|:|          ||:: ||.......::|::....|.:.|    :|.:
  Rat   554 VAKDCIRFLKEERAEPETFLALDYLDIKPINERLREIKGCKMMIDVIKTQFPQLKKVIQFVCGN- 617

  Fly   551 SIHNIPIGTEAVGNYTSSIPKAIRVYFGG---SKKFVVTASRYRSDTILTESSIRAKNQLITVDS 612
                        |....::.:|..:.|||   .|...:..:.:....:::..|...|::.:..|.
  Rat   618 ------------GLVCETVEEARHIAFGGPERRKAVALDGTLFLKSGVISGGSSDLKHKALCWDE 670

  Fly   613 QQLALVMKQCSEAVKESDSIKNAITQTDNEFERLQAV----------AKDEQEKRRK-------- 659
            ::|..:..:.::.|:|...:...: :.:.:.:::||:          :::|.|..:|
  Rat   671 KELHSLRDKRNQLVQELKELMKTL-RKETDLKQIQALVQGTNTRLKYSQNELEMIKKKHLATFYR 734

  Fly   660 ----LDQKIAHFNS----LKTEIETLQKKLEALRNSDSLDCLE----TNFCNSL---------HK 703
                |..::.:.:|    |...|...|:|:|..:  |.:|.:|    .:||..:         :|
  Rat   735 EQSQLQSELLNIDSQCTMLSEGINKQQQKIEEFQ--DKIDKVEDDIFQDFCEEIGVENIREFENK 797

  Fly   704 DLKKIFDADAELCSCLKAIDRLIIE----KNMAQTKVS-IYMLQHETQ-----IEALKESEEQSK 758
            .:|:..:.|.:.....|...||.|:    :|..:.|:: |..|:...|     |:.||::||:..
  Rat   798 HVKQQQENDQKRLEFEKQKTRLNIQLEYSRNQLKKKLNKIDTLKTTIQKGREDIDNLKKTEEECL 862

  Fly   759 AATRDF----QQLLQCLENQISDVNK--------RKSAIQ-----GLCHGEIPTSSKFPFKKEFR 806
            ....:.    :|:.:.|..|.|::.|        ||..:.     |....|:........:|:..
  Rat   863 KIVEELMVKQEQVKEVLATQSSNIEKIHIQIEEERKKFLAVDREVGKLQKEVVIIQGSLEQKQLE 927

  Fly   807 --------ELENIDLPELREAIHDFQARLECMKSVNSEAISSYQGLQNEVKQLEEGIQ------- 856
                    ::::||:..:..::.|. ..:|..::.:::|.:       ::.:.|..||
  Rat   928 KHNLLLDCKVQDIDISLMLGSLEDI-IEVELTETESTQATA-------DIYEKEASIQIDYSPLR 984

  Fly   857 ---ESVNQAKSIESGMSNLYDKWEPKLNSLVET-------------ISTKFSEFMESIEYV---- 901
               :::...|.:|:.::.|..:...:.|:|::|             :..||.|..::.|..
  Rat   985 EDWKALQSDKEVEAHLTLLLQQVASQENTLLKTAAPNLRAQENLKAVRDKFQESADAFEASRKEA 1049

  Fly   902 ----GEVVLSKTDKYD-----FDSYGIQIMVQFRR------------------------------ 927
                .|....|..:||     |:...:.|...:::
  Rat  1050 RICRQEFEQVKRRRYDAFSQCFEHISVSIDQIYKKLCRNNSAQAFLSPENPEEPYLDGISYNCVA 1114

  Fly   928 -GLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTH----VPFRCVDEINQGMDATN 977
             |.:..|:|..  ||||:.|:    :|:|....|    .||..:||::..:|.||
  Rat  1115 PGKRFMPMDNL--SGGEKCVA----ALALLFAVHSFRPAPFFVLDEVDAALDNTN 1163

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	42/155 (27%)
		Smc	22..1011	CDD:224117	230/1217 (19%)
		GrpE	212..>316	CDD:295646	19/110 (17%)
		ABC_SMC5_euk	<919..1025	CDD:213244	19/94 (20%)
Smc1b	XP_038934778.1	Smc	3..1201	CDD:224117	230/1224 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900