DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC5 and Smc5

DIOPT Version :9

Sequence 1:	NP_996141.2	Gene:	SMC5 / 326215	FlyBaseID:	FBgn0052438	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	XP_006231245.1	Gene:	Smc5 / 293967	RGDID:	1307492	Length:	1102	Species:	Rattus norvegicus

Alignment Length:	1089	Identity:	306/1089 - (28%)
Similarity:	541/1089 - (49%)	Gaps:	147/1089 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GRIHSVYCKDFVSYSEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYIQ 78
            |.|..:..::|::|......|..:||::.|.||:|||:||.||.|||.|:|..:.|:..|..:::
  Rat    51 GSIVRIAMENFLTYDICEVSPGPHLNMIIGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVK 115

  Fly    79 SNKTSATIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFLAAVSSFNIQVSNLCQFL 143
            ...:...:.:.:: ||.......|.|......|.:.:|.|..::|.....|::.||||.||||||
  Rat   116 RGCSKGLVEIELF-RTSGNLIITREIDVIKNQSFWFINKKPVTQKIVEEQVAALNIQVGNLCQFL 179

  Fly   144 PQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANVHANREKEKSDLVKKQ-KRL 207
            |||:|.:|:|::..|||..|..|:...::......||..|.::..:..:. |||::.:.|. :|.
  Rat   180 PQDKVGEFAKLSKIELLEATEKSIGPPEMHRYHCELKNFREKEKQLETSC-KEKTEYLDKMIQRN 243

  Fly   208 EHLQMTVSQYKEREEVKQKLQVYSAKKLWVETQAGEAKAAEMKTQVKNAKTQSDKLKNQHDKLLQ 272
            |..:..|.::.||:.....:::..||:.|||.:       .::.:.:..|...|::|.:..||.:
  Rat   244 ERYKQDVERFYERKRHLDLIEMLEAKRPWVEYE-------NVRQEYEGVKLVRDRVKEEVRKLKE 301

  Fly   273 SQ-------EQIEKEKESLRKALLEKTRLLENA---------VAEKAAIDGKMDSLKQGIYQKKY 321
            .|       |:||:::.:|...:.||...::.|         :.|:.  |..:..|:|.:..|:.
  Rat   302 GQIPMTRRIEEIERQRRTLEVRIKEKATDIKEASQKCKQRQDLIERK--DRHIKELQQALTVKQN 364

  Fly   322 E-------------LEQNIKKSRRTATECDNLNQLVENKIYELETLNKSRPLIVSELERAKESCA 373
            |             :.::::...|||..|:||...::              .|.::|.|.:|..|
  Rat   365 EEQDRQKRISNTRKMIEDLQNELRTAENCENLQPQID--------------AITNDLRRVQEEKA 415

  Fly   374 AARGKAMEQYSRRRQLEQK---LNDEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMNW 435
            ...|:.:::...:..||::   ::|.           |.|..|:..||.|::|.:..:...|:.|
  Rat   416 LCEGEIIDKQREKEMLEKQKRSVSDH-----------ITRFDNLMNQKEDKLRQRYRDTYDAVLW 469

  Fly   436 LAQNKQRYKLNVYDPMILELTVQNHEDAKFLENVVAQRDLFAFACEDKGDMSDLINELCVKQKLG 500
            |..|:.|:|..|.:|::|.:.::::::||::||.::..||.||..|.:.||...:.|:...:||.
  Rat   470 LRNNRDRFKQRVCEPIMLTINMKDNKNAKYVENHISSNDLRAFVFESQEDMEIFLREVRDNKKLR 534

  Fly   501 VNVIYCAPSDRLVYSPKTP---IDDLRSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGTEAV 562
            ||.: .||  ::.|:.|.|   :::|:.:||.|||.:|...|.|:::.||..|.||.:|:|||..
  Rat   535 VNAV-IAP--KISYADKAPSRSLNELKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTERT 596

  Fly   563 GNYTSSIPKAIRV--YFGGSKKFVVTASRYRSDTILTESSIRAKNQL-ITVDSQQ---LALVMKQ 621
            ......:.:..|:  .:...:|:|:..|.|.:..|.:.:|::....| :|||.:|   |...:|:
  Rat   597 RERIERVIQETRLKQIYTAEEKYVLKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKE 661

  Fly   622 CSEAVKESDSIKNAITQT-------DNEFERLQAVAKDEQEKRRKLDQKIAHFNSLKTEIETLQK 679
            .:..::..||...|:..|       |||....:....:.:.|:|:|:|||:             .
  Rat   662 INRKLEAVDSGLVALRDTNRHLELKDNELRLKKKELLERKTKKRQLEQKIS-------------S 713

  Fly   680 KLEALRNSDSLDCLETNFCNSLHKDLK---KIFDAD-------AELCSCLKAIDRLIIEK---NM 731
            ||.::|      .:|.:.||...::.|   ||.:.:       .||...:|....|.|:|   .:
  Rat   714 KLASIR------LMEQDTCNLEEEERKASTKIKEINVQKAKLVTELTGLVKICTSLHIQKVDLIL 772

  Fly   732 AQTKVSIYMLQHETQIEA--------LKESEEQSKAATRDFQQLLQ-CLE-----NQISDVNKRK 782
            ..|.|    :..:.::||        |:.:|:|......:.|:||| |.|     .|:.:::..:
  Rat   773 QNTTV----ISEKNKLEADYMASSSQLRVTEQQFIELDDNRQRLLQKCKELMKRARQVCNLSADQ 833

  Fly   783 SAIQGLCHGEIPT-----SSKFPFKKEFRELENIDLPELREAIHDFQARLECMKSVNSEAISSYQ 842
            :..|.. ..::||     ||..|.  .|::|.| .|.|:...:.:.::|..|...:|...:..|.
  Rat   834 AVPQEF-QTQVPTIPNGHSSSPPM--AFQDLPN-TLDEIDALLTEERSRASCFTGLNPSVVEEYT 894

  Fly   843 GLQNEVKQLEEGIQESVNQAKSIESGMSNLYDKWEPKLNSLVETISTKFSEFMESIEYVGEVVLS 907
            ..:.|::||.|.::....:.......:|.:.::|...|..|||.|:.|||.|..|::..|||.|.
  Rat   895 KREIEIQQLTEELKGKKVELDEYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLH 959

  Fly   908 KTDKYDFDSYGIQIMVQFRRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQG 972
            ..::.|:|.|||:|.|:||...||..|....||||||:||..:|.::||.:...|||.|||||||
  Rat   960 TENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQG 1024

  Fly   973 MDATNERHIFDLLLKEATKHGSAQYLFVTPKLLRDLNYNEHLCVSIVHN 1021
            ||..|||.:|::::..|.|..::||.|:|||||::|.|:|.:.|..|:|
  Rat  1025 MDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYN 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	50/145 (34%)
		Smc	22..1011	CDD:224117	299/1069 (28%)
		GrpE	212..>316	CDD:295646	25/119 (21%)
		ABC_SMC5_euk	<919..1025	CDD:213244	51/103 (50%)
Smc5	XP_006231245.1	ABC_SMC5_euk	51..>196	CDD:213244	50/145 (34%)
		Smc	53..1055	CDD:224117	295/1067 (28%)
		ABC_SMC5_euk	<975..1077	CDD:213244	49/99 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	381	1.000	Domainoid score	I802
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41009
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1853
OMA	1	1.010	-	-		QHG54387
OrthoDB	1	1.010	-	-		D100993at2759
OrthoFinder	1	1.000	-	-		FOG0004754
OrthoInspector	1	1.000	-	-		oto98415
orthoMCL	1	0.900	-	-		OOG6_102083
Panther	1	1.100	-	-	LDO	PTHR45916
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3345
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880