Protein Alignment SMC5 and SMC1B

DIOPT Version :9

• Sequence 1: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_683515.4
• Gene: SMC1B / 27127
• HGNCID: 11112
• Length: 1235
• Species: Homo sapiens
• Alignment Length: 1221
• Identity: 244/1221 - (19%)
• Similarity: 444/1221 - (36%)
• Gaps: 331/1221 - (27%)

  Fly    34 PKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYIQSN------KTSATIIVRVYG 92
            |......:.||||||||.::.|:...: ||.|...|..::.:.|...      .:||::.: :|.
Human    23 PFRRFTCIIGPNGSGKSNVMDALSFVM-GEKIANLRVKNIQELIHGAHIGKPISSSASVKI-IYV 85

  Fly    93 RTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFLAAVSSFNI------------QVSNLCQFLPQ 145
            ......:||.|||. .|.|.|..||...|:..::|.:....|            .|.::....|:
Human    86 EESGEEKTFARIIR-GGCSEFRFNDNLVSRSVYIAELEKIGIIVKAQNCLVFQGTVESISVKKPK 149

  Fly   146 DRVQDFSKMNPQELLLNTMS------SVCDEDLINSFNSLKQMRTEQANVHANREKEKSDLVKKQ 204
            :|.|.|.:::....|:....      ...:||...:||..|.:..|:.  .|..|||:::  :.|
Human   150 ERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERR--QAKLEKEEAE--RYQ 210

  Fly   205 KRLEHLQMTVSQYKEREEVKQKLQVY-SAKKLWVETQAGEAKAAEMKTQVKNAKTQSDKL---KN 265
            ..||.|:|...|.       |..|:| :.||:.:.....|....::..:.::.....:.:   |.
Human   211 SLLEELKMNKIQL-------QLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKK 268

  Fly   266 QHDKLLQSQEQIEKEKESLRKALLEK----TRLLENA--------VAEKAAIDGKMDSLKQGIYQ 318
            :|..|.:..:|.|||.:|:...|.:|    .:..||.        ||:|:..|.:....||
Human   269 EHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQ---- 329

  Fly   319 KKYELEQNIKKSRRTATECDNLNQLVENKIYELETLNKSR--PLIVSELERAKESCAAARGK--A 379
                 |.:||.......:.|...:..|.:|.| |.|:|.|  .|..|:|:|.||.....|.|  .
Human   330 -----EDDIKALETELADLDAAWRSFEKQIEE-EILHKKRDIELEASQLDRYKELKEQVRKKVAT 388

  Fly   380 MEQYSRRRQLEQKLNDEMI------------------PEITAYKLKIERLRNVKMQKIDEIRAKN 426
            |.|...:.|.|||.::|.:                  .:|..:|.:||:|.......:|.::.|.
Human   389 MTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKK 453

  Fly   427 PNLVVAMNWLAQNKQRY-----KLNVYDPMILELTVQNHED------AKFLENVVAQRDLFAFAC 480
            ......::.:.:.|.|.     :||:....:....:..||.      |:.||::........|
Human   454 QQEETLVDEIEKTKSRMSEVNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVF-- 516

  Fly   481 EDKGDMSDLINELCVKQKLGVNVIY-------CAPSDRLV-----------YSPKT--------- 518
               |.:.||.:.:..|.:|.|..::       ...|:::.           ..|:|
Human   517 ---GRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDI 578

  Fly   519 -PIDD-LRSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGT-EAVGNYTSSIPKAIR------ 574
             ||:: ||.......::|::....|.:.|:......:.:...| |...:...|.|:..:
Human   579 KPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDG 643

  Fly   575 -------VYFGGSK----------------------------KFVVTASRYRSD-----TILTES 599
                   |..|||.                            |.::...|..:|     |::..:
Human   644 TLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGT 708

  Fly   600 SIRAK-------------------------NQLITVDSQQLALVMKQCSEAVKES---------- 629
            ..|.|                         ::|:.::||.:.|     ||.:||.
Human   709 QTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIML-----SEGIKERQRRIKEFQEK 768

  Fly   630 -DSIKNAITQTDNE---FERLQAVAKDEQEKRRKLDQKIAHFNSLKTEIET--------LQKKLE 682
             |.:::.|.|...|   .|.::.......::::::|||...|...||.:..        |:|||.
Human   769 IDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLN 833

  Fly   683 AL--------RNSDSLD--------CLETNFCNSLHKDLKKIFDADAELCSCLKAIDRLIIEKNM 731
            .:        :.|:.:|        ||:|  .|.|....:::.|......|..:.:...|.|:..
Human   834 KINTLKETIQKGSEDIDHLKKAEENCLQT--VNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERK 896

  Fly   732 AQTKVSIYMLQHETQIEALKESEEQSKAATRDFQQLLQCLENQISDVNKRKSAIQGLCHGEIPTS 796
            ....|...:.:.:.::.:::.|.||.:....:.  ||.|....| ::.....::..:...|:.|.
Human   897 KFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNL--LLDCKVQDI-EIILLSGSLDDIIEVEMGTE 958

  Fly   797 SKFPFKKEFRELENIDLPELREAIH-DFQARLECMKSVNSEAISSYQGLQNEVKQLEEGIQESVN 860
            ::       .....||:.|..||.. |:.:..|.:|::.|:            :::|..::..:.
Human   959 AE-------STQATIDIYEKEEAFEIDYSSLKEDLKALQSD------------QEIEAHLRLLLQ 1004

  Fly   861 QAKSIESGMSNLYDKWEPKLNSL--VETISTKFSEFMESIEYV--------GEVVLSKTDKYD-- 913
            |..|.|   ..|.....|.|.:|  ::|:..||.|..::.|..        .|....|..:||
Human  1005 QVASQE---DILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLF 1066

  Fly   914 ---FDSYGIQIMVQFRR-------------------------------GLQLQPLDKFIQSGGER 944
               |:...|.|...:::                               |.:..|:|..  ||||:
Human  1067 TQCFEHVSISIDQIYKKLCRNNSAQAFLSPENPEEPYLEGISYNCVAPGKRFMPMDNL--SGGEK 1129

  Fly   945 AVSIAIYSLSLQHVTH----VPFRCVDEINQGMDATNERHIFDLLLKEATK 991
            .|:    :|:|....|    .||..:||::..:|.||...: ...:||.|:
Human  1130 CVA----ALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKV-SSYIKEQTQ 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	36/143 (25%)
		Smc	22..1011	CDD:224117	244/1221 (20%)
		GrpE	212..>316	CDD:295646	26/119 (22%)
		ABC_SMC5_euk	<919..1025	CDD:213244	23/108 (21%)
SMC1B	NP_683515.4	Smc	3..1219	CDD:224117	244/1221 (20%)
		ABC_SMC1_euk	4..>148	CDD:213242	32/127 (25%)
		DUF342	<421..492	CDD:302792	11/70 (16%)
		SMC_hinge	513..628	CDD:214944	19/119 (16%)
		ABC_SMC1_euk	<1113..1216	CDD:213242	21/70 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810