DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC5 and smc5

DIOPT Version :9

Sequence 1:	NP_996141.2	Gene:	SMC5 / 326215	FlyBaseID:	FBgn0052438	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_594907.2	Gene:	smc5 / 2541587	PomBaseID:	SPAC14C4.02c	Length:	1076	Species:	Schizosaccharomyces pombe

Alignment Length:	1143	Identity:	303/1143 - (26%)
Similarity:	504/1143 - (44%)	Gaps:	221/1143 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSSKQLAGRIHSVYCKDFVSYSEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSA 71
            |.|....|.|..:...:||:|......|..|||::.||||:|||||||||.:|||..|.||.|:.
pombe    15 LYSDYALGSIVRIKLVNFVTYDYCELFPGPYLNLIIGPNGTGKSTIVSAICIGLGWPPKLLGRAK 79

  Fly    72 SVADYIQSNKTSATIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFLAAVSSFNIQV 136
            ...::|:..|.:|||.:.:..|...|. |..|.|:.:..|:||:|.:..:..:..:.:.:||:|:
pombe    80 EAREFIKYGKNTATIEIEMKYRDDETV-TITRQISQDKSSSFSINREACATSSITSLMDTFNVQL 143

  Fly   137 SNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANVHANREKEKSDLV 201
            :|||.|||||||.:|::::|...|:.|..::..|.|:.:...|..:|..:..:..|:.:.:|.|.
pombe   144 NNLCHFLPQDRVAEFAQLDPYSRLMETERAIDHEGLLPAHEKLIDLRKREREILQNKNQGQSTLN 208

  Fly   202 KKQKRLEHLQMTVSQYKEREEVKQKLQVYSAKKLWVETQAGEAKAAEMKTQVKN-AKTQSDKLKN 265
            ..:.|.:.|:..|:.:||||::|..:::....|:.|        ....||.|.| .:....|||.
pombe   209 SLKDRQQALEKEVNIFKEREKIKSYIEMLGLAKMLV--------IYREKTNVFNQLRADKKKLKK 265

  Fly   266 QHDKLLQSQEQIEKEKESLRKALLEKTRLLENAVAEKAAIDGKMDSLKQGIYQ--KKYELEQNIK 328
            ....|::..:.|..:.|.||..|                      .||...:.  ....:|.|..
pombe   266 DLKDLVEEFQPILDKGEELRSDL----------------------KLKDDTFNDYSSASMELNTS 308

  Fly   329 KSRRTATECDNLNQLVEN--KIYEL----ETLNKSRPLIVSELERAKESCAAARGKAMEQYSRRR 387
            ..|..|    :.:..:||  |:||.    .||.::..|.::|.:::.:|....:|.        |
pombe   309 NLRARA----SFSNFMENEKKLYEKVNTNRTLLRNANLTLNEAQQSVKSLTERQGP--------R 361

  Fly   388 QLEQKLND--EMIPEITAYKLKIER-----------LRNVKMQKI--------------DEIRAK 425
            ..:..:.|  |.:.|:.|.||:.|.           :|.:|.||:              |..:.|
pombe   362 PSDNGVQDLQEKMQEVNAEKLQHENEKLESSHELGSIRTLKAQKLIDLDNIKRELSYYNDATKRK 426

  Fly   426 NPNLVVAMNW---------LAQNKQRYKLNVYDPMILELTVQNHEDAKFLENVVAQRDLFAFACE 481
            ...:..|..|         |.:.:..::...|.|:.:.|..:....|..:|..........|...
pombe   427 LDFMSSAPGWEDAYQTYQLLKEYESAFEAPAYGPIYMNLKCKEKGFAALIEGFFRTDTFRTFIMS 491

  Fly   482 DKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSP---------KTPIDD---------LRSFGF 528
            :..|...|::.:..|.|               |:|         |..|:|         |:||||
pombe   492 NYNDYLKLMDLITSKTK---------------YTPTIREFSSERKKKIEDFEPPCSREKLQSFGF 541

  Fly   529 RSYLVDLVTGPIPLINKLCASYSIHNIPI--------GTEAVGNY-TSSIPKAIRVYFGGSKKFV 584
            ..|::|.:.||..::..||....||.|||        ...|:.|: .::....::.|..||...:
pombe   542 DGYVIDFLEGPEVVLVALCHMLKIHQIPIAKRELPPASVNALNNFRLANGDPVLKTYLAGSSIHL 606

  Fly   585 VTASRY-------RSDTILTESSIRAKN---QLITVDSQQLALVMKQCSEAVKESDSIKNAITQT 639
            |..|.|       |:|.:.:.|...::|   .|:....:||...:.|......|...::..:.:.
pombe   607 VFRSAYGDREITRRTDPLPSRSIYFSENVEMDLVKRKEEQLNAQLSQLENLQNEERKLQEKVNEH 671

  Fly   640 DNEFER----LQAVAKDEQEKR------RKLDQKIAHFNSLKTEIETLQKKLEALRNSDSLDCLE 694
            ::...|    |..:.|:..||.      ::|.::|.|...|..:.|.:.::..|.        :|
pombe   672 ESLLSRTNDILSTLRKERDEKLIPIHEWQQLQERIEHQTLLLRQREKVPEQFAAE--------IE 728

  Fly   695 TNFCNSLHKDLKKIFDADAELCSCLKAIDRLIIEKN----MAQTKVSI----YMLQ-HE---TQI 747
            .|      :|::| .:.:|.:.|.||..:..|...|    |..:::::    |.|: ||   .|:
pombe   729 KN------EDIRK-ENFEALMNSVLKVKENSIKATNNFEKMLGSRLNVIEAKYKLEKHEMDANQV 786

  Fly   748 EA--------LKESEEQSKAATRD----FQQLLQCLENQISDVNKRKSAIQGLCHGEIPTSSKFP 800
            .|        ||:..::..:|..|    :..::..|:.|.||   |::||..| :.|..|||
pombe   787 NARLTEVQDRLKDITDKLASAREDAMSLYGSVVDSLQTQSSD---RQTAITEL-NEEFATSS--- 844

  Fly   801 FKKEFRELEN-IDLPELREAIHDFQARLECMKSVNSEAISSYQGLQNEVKQLEEGIQESVNQAKS 864
                  |::| |.:.|         .:|:.| :|||..:..|...:.|:::||..:.:.....:.
pombe   845 ------EVDNKISIEE---------TKLKFM-NVNSYVMEQYDARKKEIEELESKMSDFDQSVEE 893

  Fly   865 IESGMSNLYDKWEPKLNSLVETISTKFSEFMESIEYVGEVVLSKTDKYDFDSYGIQIMVQFRRGL 929
            ::..|:::.:.|..||...|:.||.:||:.|..:.|.|||.|.|:|  |:|.:.|.|:||||...
pombe   894 LQDEMNSIKEDWVSKLEENVQCISDRFSKGMSGMGYAGEVRLGKSD--DYDKWYIDILVQFREEE 956

  Fly   930 QLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHGS 994
            .||.|....||||||:||..:|.||||.:...|||.|||||||||..|||.:...::.....:..
pombe   957 GLQKLTGQRQSGGERSVSTIMYLLSLQGLAIAPFRIVDEINQGMDPRNERVVHRHIVNSVCDNAV 1021

  Fly   995 AQYLFVTPKLLRDLNYNEHLCVSIVHNSKTVCHGMQFP 1032
            :||..||||||.||.|:.:|.|      ..:|:|...|
pombe  1022 SQYFLVTPKLLPDLTYHRNLKV------LCICNGAWLP 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	58/145 (40%)
		Smc	22..1011	CDD:224117	293/1105 (27%)
		GrpE	212..>316	CDD:295646	23/104 (22%)
		ABC_SMC5_euk	<919..1025	CDD:213244	50/105 (48%)
smc5	NP_594907.2	ABC_SMC5_euk	22..>167	CDD:213244	58/145 (40%)
		Smc	24..1067	CDD:224117	300/1134 (26%)
		Orbi_VP5	632..>884	CDD:279272	63/289 (22%)
		ABC_SMC5_euk	<946..1052	CDD:213244	52/111 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	164	1.000	Domainoid score	I953
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41009
Inparanoid	1	1.050	310	1.000	Inparanoid score	I578
OMA	1	1.010	-	-		QHG54387
OrthoFinder	1	1.000	-	-		FOG0004754
OrthoInspector	1	1.000	-	-		oto101942
orthoMCL	1	0.900	-	-		OOG6_102083
Panther	1	1.100	-	-	LDO	PTHR45916
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1355
SonicParanoid	1	1.000	-	-		X3345
TreeFam	1	0.960	-	-
	14	13.860