DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMC5 and Smc1a

DIOPT Version :9

Sequence 1:NP_996141.2 Gene:SMC5 / 326215 FlyBaseID:FBgn0052438 Length:1034 Species:Drosophila melanogaster
Sequence 2:NP_062684.2 Gene:Smc1a / 24061 MGIID:1344345 Length:1233 Species:Mus musculus


Alignment Length:1255 Identity:242/1255 - (19%)
Similarity:473/1255 - (37%) Gaps:355/1255 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 GRIHSVYCKDFVSY-SEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYI 77
            |.:..:..::|.|| ......|......:.||||||||.::.||...||.:...| |..::.|.|
Mouse     2 GFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNL-RVKTLRDLI 65

  Fly    78 QS---NKTSA--TIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFLAAVSSFNIQVS 137
            ..   .|.:|  ..:..||........||.|:| ..|.|.:.:|:|......:...:....|.:.
Mouse    66 HGAPVGKPAANRAFVSMVYSEEGAEDRTFARVI-VGGSSEYKINNKVVQLHEYSEELEKLGILIK 129

  Fly   138 --NLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANVHANREKEKSDL 200
              |...|  |..|:..:..||:|     .:::.:|  |:....|.|          ..:|.|.::
Mouse   130 ARNFLVF--QGAVESIAMKNPKE-----RTALFEE--ISRSGELAQ----------EYDKRKKEM 175

  Fly   201 VKKQKRLE---HLQMTVSQYKEREEVKQ--------------------KLQVYSAKKLWVETQAG 242
            ||.::..:   |.:..::  .||:|.||                    :||::......||.:..
Mouse   176 VKAEEDTQFNYHRKKNIA--AERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKL 238

  Fly   243 EAKAAEMKTQVKNAKTQSDKL-------KNQHDKLLQSQEQIEKE------------------KE 282
            ..:.|....:::..|.:.||:       |.:..|:::.|:|||||                  ||
Mouse   239 NKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKE 303

  Fly   283 SLR---KALLEKTRLLENAVAEKAAIDGKMDSLKQGI---------YQKKYE-----------LE 324
            :..   |.|....:.|:||........|.||.|::.:         ::::.|           ||
Mouse   304 NTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLE 368

  Fly   325 QN-IKK--------SRRTAT---ECDNLNQ----------LVENKIYELETLNKSRPLIVSELER 367
            :| :||        |:|.||   |.:..|:          |.|.|..|.|...|.:   :.|:|.
Mouse   369 ENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQK---LREIEE 430

  Fly   368 AKESCAAARGKAMEQY--SRRRQLEQ--KLNDEMIPEITAYKLKIERLR---NVKMQKIDEIR-- 423
            .::     |.:.:|:|  :.::.||:  ||..|:..|:...|.:|:.:.   |..|:::.:.|  
Mouse   431 NQK-----RIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARID 490

  Fly   424 ----AKNPNLVVAMNWLAQNKQRYKLNVYDPMI--LELTVQNHE-----------DAKFLENVVA 471
                ::.......|..:   |:.|..:||..:|  .:.|.:.::           ||..:::...
Mouse   491 RQESSRQQRKAEIMESI---KRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKT 552

  Fly   472 QRDLFAFACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVDLV 536
            .||...:..|.:|:....:                 |.|.|...|..  :.||.......::|::
Mouse   553 GRDCIQYIKEQRGEPETFL-----------------PLDYLEVKPTD--EKLRELKGAKLVIDVI 598

  Fly   537 TGPIPLINKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGGSKKFVVTA---SRYRSDTILT- 597
            ....|.|.| ...|:..|..:        ..::..|.|:.|||.::....|   :.::...::: 
Mouse   599 RYEPPHIKK-ALQYACGNALV--------CDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISG 654

  Fly   598 -ESSIRAKNQ--------LITVDSQQLALVMKQCSEAVKESDSIKNA------------ITQTDN 641
             .|.::||.:        .:....::|...:|:..:|.::...::..            .:|:|.
Mouse   655 GASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDL 719

  Fly   642 EFERLQAVAKDEQEKRRKLDQKIAHF----NSLKTEIETLQKKLEALRNSDSLDCLE----TNFC 698
            |..:.:.:|.:.||| .||:.::|:|    |.:|..|::.:::::.|:  :.::.:|    ..||
Mouse   720 EQTKTRHLALNLQEK-SKLESELANFGPRINDIKRIIQSREREMKDLK--EKMNQVEDEVFEEFC 781

  Fly   699 NSLHKDLKKIFDADAELCSCLKAIDR---------------LIIEKNMA---QTKVSIY---MLQ 742
            ..:  .::.|.:.:.|.......|.:               |..|||..   |.||.::   :.:
Mouse   782 REI--GVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKK 844

  Fly   743 HETQIEALKESEEQSKAATRDFQQLLQCLENQ-------ISDVNKRKSAIQGLCHG--------- 791
            .|.:||.||:.|::......:....||.|:||       ::|.|.....|:....|         
Mouse   845 DENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQ 909

  Fly   792 -EIPT-SSKFPFKKEFR-------ELENIDLPELREAIHDFQARLECMKSVNSEAISSYQ----- 842
             |:.. .:|...|:..|       ::::|.||..:..:.|...  |...|...|::|..|     
Mouse   910 KEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQ--EEGSSQGEESVSGSQRTSSI 972

  Fly   843 ---------------------GLQNEVKQLEEGIQESVNQAKSIESGMSNLYDKWEPKLNSL--V 884
                                 ..:.|:||....:|:.:|:.:|:...::      .|.:.::  :
Mouse   973 YAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIA------APNMKAMEKL 1031

  Fly   885 ETISTKFSEFMESIEYV-----------GEVVLSKTDKYD--FDSYGIQIMVQFRR--------- 927
            |::..||.|..:..|..           .::...:.|:::  |:|....|...::.         
Mouse  1032 ESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQA 1096

  Fly   928 ----------------------GLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEIN 970
                                  |.:.:|:|..  ||||:.|:......::......||..:|||:
Mouse  1097 FLGPENPEEPYLDGINYNCVAPGKRFRPMDNL--SGGEKTVAALALLFAIHSYKPAPFFVLDEID 1159

  Fly   971 QGMDATNERHIFDLLLKEAT 990
            ..:|.||...:.:.:.:::|
Mouse  1160 AALDNTNIGKVANYIKEQST 1179

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC5NP_996141.2 ABC_SMC5_euk 14..>160 CDD:213244 41/153 (27%)
Smc 22..1011 CDD:224117 241/1247 (19%)
GrpE 212..>316 CDD:295646 32/151 (21%)
ABC_SMC5_euk <919..1025 CDD:213244 18/103 (17%)
Smc1aNP_062684.2 SMC_N 3..1210 CDD:308206 241/1254 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 284..308 2/23 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..369 2/20 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 947..969 6/23 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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