DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMC5 and smc4

DIOPT Version :9

Sequence 1:NP_996141.2 Gene:SMC5 / 326215 FlyBaseID:FBgn0052438 Length:1034 Species:Drosophila melanogaster
Sequence 2:NP_775360.2 Gene:smc4 / 192332 ZFINID:ZDB-GENE-020419-21 Length:1289 Species:Danio rerio


Alignment Length:1275 Identity:265/1275 - (20%)
Similarity:482/1275 - (37%) Gaps:375/1275 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ALSSKQLAGR--IHSVYCKDFVSYS-EITFHPKH-YLNVLTGPNGSGKSTIVSAI--ILGLGGEP 64
            |:||:..|.|  |..:..::|.||: |....|.| ..:.:.||||||||.::.::  :.|...:.
Zfish    71 AMSSEPGAPRLMITHIVNRNFKSYAGEQILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQK 135

  Fly    65 ILLDRSASVADYIQSNK-----TSATIIVRV----------YGRTPNTTETFRRIINSNGLSTFS 114
            |   ||..::..|.|:.     .|.|:.|..          |...|:::....|....:..|.:.
Zfish   136 I---RSKKLSVLIHSSDGHPDIQSCTVEVHFQKIIDKEGDDYDVIPDSSFYVARTAGKDNSSAYY 197

  Fly   115 VNDKDTSKKNFLAAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQ------ELLLNTMSSVCDEDLI 173
            :|.|..:.|:....:.|..|.:.:....:.|..|:..:.|.|:      |.:|..:     ||:|
Zfish   198 INTKKATFKDVGTLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYL-----EDII 257

  Fly   174 NS-------------FNSLKQMRTEQANVHANREKEKS-----------------DLVKKQKRLE 208
            .|             ..:|.:.|.|:.|.....|||||                 |:.||:..|.
Zfish   258 GSCRLKEPINILCRRVEALNEQRGEKLNRVKMVEKEKSALEGEKNKAVDFLSLENDIFKKRNLLC 322

  Fly   209 H-----LQMTVS-------QYKE------------REEVKQKLQVYSA--KKL-----WVETQAG 242
            |     ||..||       |.:|            .||:|.|.:...|  |||     ::|:|..
Zfish   323 HFYVHDLQSRVSVKEAEKQQIQEDTKDLSDKSSQLTEEMKSKNEDLKAVEKKLTKLTKYIESQKE 387

  Fly   243 -----EAKAAEMKTQVKNAKTQSDKLKNQHDKLLQSQEQIEK--------EK----ESLRKALLE 290
                 :.:..|::.::|:.|:::.||:.|   |.:.||::|:        ||    .|.:|..||
Zfish   388 KFTQLDLQDVEVREKLKHTKSKTKKLQKQ---LQKDQEKLEEVRGVPASSEKIITEASAQKEELE 449

  Fly   291 KTRLLENAVAEKAAIDGKMDSLKQ---GIYQKKYELEQNIKKSRRTATECDNLNQLVENK--IY- 349
            |.:|||.   :|.|  ..|:|||:   |:.:.|.:.|:.:.:..::..|..:...:.:::  || 
Zfish   450 KKKLLEE---QKLA--EVMESLKEETKGLQEDKEKKEKELLELSKSVNETRSRMDVAQSELDIYL 509

  Fly   350 -----ELETLNKSRPLIVSELERAKESCAAARGKAMEQYSRRRQLEQKLNDEMIPEITAYKLKIE 409
                 .:..||:::..:...::..:|..||.:...::..::..||  |.::..:.:|:      |
Zfish   510 SQHNTAINQLNQAKSALQETVDTLRERRAAIKDLQVKIPAQEEQL--KKDERELEQIS------E 566

  Fly   410 RLRNVKMQKIDEIRAKNPNLVVAMNWLAQNKQRYKLNVYDPMILELTVQNHEDAKFLENVVAQRD 474
            :.:..:.| :.::|.|   :..|.:.|:.|:.|.|       :|:..:|.....|....:....|
Zfish   567 QDKQTRAQ-VGDMRQK---VAEAKSSLSSNRSRSK-------VLDTLMQQKRSGKIPGILGRLGD 620

  Fly   475 LFAFACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVDLVTGP 539
            |.|.  ::|.|::  |:..|                       ..:|::        |||    .
Zfish   621 LGAI--DEKYDVA--ISSSC-----------------------GSLDNI--------LVD----T 646

  Fly   540 IPLINKLCASYSIHNIPIGT-----------EAVGNYTS--SIPK---AIRVYFGGSKKFVVTAS 588
            |....|........||.:.|           :::|:.::  :||:   .:||.....:.....|.
Zfish   647 IDTAQKCVTFLKAQNIGVATFIGLDKMKVWQQSMGSISTPENIPRLFDMVRVKDESVRPAFYFAL 711

  Fly   589 RYRSDTILT---ESSIRAKNQ------LITVDSQQL----------ALVMK------QCSEAVKE 628
            |   ||::.   |.:.|...|      ::|:..|.:          ..|||      .|::..:|
Zfish   712 R---DTLVAKDLEQATRVAFQKDKRWRVVTLQGQIIEQAGTMTGGGGRVMKGRMGSSVCADVTQE 773

  Fly   629 S-DSIKNAITQTDNEFERLQAVAKDEQEKRRKLDQKI------------------AHFNSL---- 670
            . |.:::|:   :.|..:||    |.|:::.:|::|:                  |...||    
Zfish   774 QLDKMESAL---NKEVTQLQ----DCQKRKNQLEEKVHKARCELRDMKNTLEKYTATIQSLTEQE 831

  Fly   671 --------------------KTEIETLQKKLEALR---------------------------NS- 687
                                |.:.:.::|.|||.|                           || 
Zfish   832 LHLKPQIKDLEANVIAAAPDKAKQKQMEKSLEAYRKDFEAASNKAGKVEAEVKRLHTLIVDINSH 896

  Fly   688 ------DSLDCLETNF--CNS-----------LHKDLKKIFDA----DAELCSCLKAIDRLIIEK 729
                  |.||.:.|..  |:|           ..::|||..|.    :.|:....|.::.|..:.
Zfish   897 KLKAQQDKLDQINTQLDQCSSAVTKAQVAIKTAGRNLKKSEDGVSRLEQEISENEKLMEELTEQL 961

  Fly   730 NMAQTKVSIYMLQHETQIEALKESEEQSKAATRDFQQLLQ---CLENQISDVNKRKSAIQGL--- 788
            ...:.:....|..::...|||.|.::|.:|..::.:.|.:   .|:.:...|..:...|...   
Zfish   962 KKLEEQAGEIMQSYQQAEEALPEVQDQHRAVVQEIKALQEQEHALQKESLSVRLKVEHIDTAITE 1026

  Fly   789 CHGEIPTSSKFPFKKEFRELENI---DLPELR----------EAIHDFQARLE--C--MKSVNSE 836
            ||.:|....|...|.....::.:   :||.|.          :.|.:..|.||  |  ||. |..
Zfish  1027 CHNKIKHWQKEASKLCLHHIDGVPAEELPALNPDQLQDIGNPDVIKNEIALLEDRCANMKP-NLG 1090

  Fly   837 AISSYQGLQNEVKQLEEGIQESVNQAKSIESGMSNLYDKWEPKLNSLVETISTKFSEFMESIEYV 901
            ||:.::..:....|....:.:...|..|.:.|..:|..:...:..:....|:.|..|..:.:...
Zfish  1091 AIAEFKKKEELYLQRVAELDDITTQRDSFKRGCEDLRKQRLHEFMAGFNIITNKLKENYQMLTLG 1155

  Fly   902 GEVVLSKTDKYDFDSYGIQIMVQFRRGLQLQPLDK-----FIQSGGERAVSIAIYSLSLQHVTHV 961
            |:..|...|..|..|.||...|        :|..|     :..||||:.:|......:|.|....
Zfish  1156 GDAELELVDSLDPFSEGIMFSV--------RPPKKSWKKIYNLSGGEKTLSSLALVFALHHFKPT 1212

  Fly   962 PFRCVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVT 1001
            |...:|||:..:|..|. .|....:.|.||  :||::.::
Zfish  1213 PLYFMDEIDAALDFKNV-SIVACYIYEQTK--NAQFIIIS 1249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC5NP_996141.2 ABC_SMC5_euk 14..>160 CDD:213244 39/172 (23%)
Smc 22..1011 CDD:224117 259/1257 (21%)
GrpE 212..>316 CDD:295646 40/149 (27%)
ABC_SMC5_euk <919..1025 CDD:213244 23/88 (26%)
smc4NP_775360.2 ABC_SMC4_euk 81..>240 CDD:213241 36/161 (22%)
SMC_N 82..1273 CDD:280601 260/1264 (21%)
DUF4349 <274..435 CDD:305044 40/163 (25%)
SMC_hinge 612..726 CDD:214944 26/155 (17%)
MIT_CorA-like <866..1025 CDD:294313 27/158 (17%)
ABC_SMC4_euk <1180..1274 CDD:213241 20/73 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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