Protein Alignment SMC5 and C23H4.6

DIOPT Version :9

• Sequence 1: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_001257189.1
• Gene: C23H4.6 / 181384
• WormBaseID: WBGene00007694
• Length: 1137
• Species: Caenorhabditis elegans
• Alignment Length: 1226
• Identity: 267/1226 - (21%)
• Similarity: 467/1226 - (38%)
• Gaps: 351/1226 - (28%)

  Fly     1 MAGDRALSSKQLAGRIHSVYCKDFVSYSE--ITFHPKH----YLNVLTGPNGSGKSTIVSAIILG 59
            |.|::.:    :|||:.|::.|:|:.::.  |.|...:    |:.   ||||||||.:.:|:.:|
 Worm    31 MDGEKVI----IAGRVASIHLKNFMCHANLLIEFDVANKNCFYIG---GPNGSGKSALFAAMNMG 88

  Fly    60 LGGEPILLDRSASVADYIQSNKTSATIIVRV----------YGRTPNTTETFRRIINSNGLSTFS 114
            |||.....:|..:|..||:...|.|.|.:.:          |....:...|..|..:...:....
 Worm    89 LGGRGSDSERGNNVQAYIKDGTTQAKITITLTNEGLNALPEYDELISIERTINRTASKYTIRNIK 153

  Fly   115 VNDK--------DTSKKNFLAAVSSFNIQVSNLCQFLPQDRVQDF-SKMNPQELLLNTMSSVCDE 170
            ||..        .|.|.:..:.|:..||.::|...::.|||.:.| :...|..:....:.|...|
 Worm   154 VNTHKYKMERVVSTKKSDVDSVVTRLNIHLTNPAFWMSQDRSRSFLANFKPSTVYKLYLESTNLE 218

  Fly   171 DLINSFNSL-----------------------KQMRTEQANV-HANREKEKSDLV---------- 201
            ::..|:|..                       |..|.:::.| ....||:::.|.
 Worm   219 NIRQSYNRFAESIDHSAELVTAKSEEIANEKRKLKRAQESRVLQLKLEKDRNLLASYRWKFLFCR 283

  Fly   202 ------------KKQ---KRLEHLQMTVSQYK---EREEVKQKLQVYSAKKLWVETQAGEAKAAE 248
                        |||   |:| |.::..:.||   ||.||::|||....:   ||.|..|.|  |
 Worm   284 VRDYDNNIMLNKKKQEVHKKL-HKEVKDAYYKNRTERSEVQKKLQELRDE---VEVQDEEIK--E 342

  Fly   249 MKTQVKNAKTQSDKLKNQHDKLLQSQEQIEKEKES---LRKALLEKTRLLENAVAEKAAIDGKMD 310
            .:..|.|.:...:.||::   :..|:.|:.::|..   :||.:.:..:.|..|:.
 Worm   343 SRADVDNLRKIVNDLKHE---IKMSESQMRRKKVEIMLIRKEIAKAQKQLREALG---------- 394

  Fly   311 SLKQGIYQKKYELEQNIKKSRRTATECDNLN-QLVENKIYELETLNKSRPLIVSELERAKESCAA 374
                     |:..|:..||......:.::|| ::.|.:..:|:.|.|....:..||...:|....
 Worm   395 ---------KFGHEELTKKLAEAEDKRESLNIEIEEIEHVQLKALRKKYEKLTKELRNEEEEKFN 450

  Fly   375 ARGKAMEQYSRRRQLEQKLNDEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMNWLAQN 439
            .|||..   :.||.:||   |:.|            ||::|..|.:::....|.:...:..:...
 Worm   451 TRGKIA---TLRRTIEQ---DQKI------------LRSMKATKKNDVNKFGPYMSEILTEIDHR 497

  Fly   440 KQRYKLNVYDPMILELTVQNHEDAKFLENVVAQRDLFAFACEDKGDMSDLINE-LCVKQKLGV-- 501
            ..::|.....|:           .|::..|..:     :||..:....::.|. ||..|:...
 Worm   498 SSQFKQKPKGPL-----------GKYVTLVEPK-----WACATEECFKNIANNFLCCSQEDAATL 546

  Fly   502 ----NVIYCAPSDR--LVYSPKTPI--DDLRSFG--FRSYLVDLVTGPIPLINKL-----CASYS 551
                :::....:||  :|.|..|.|  :||:..|  |::....|....:.:.|.:     |..:.
 Worm   547 RKIFDILKIPSNDRPTIVVSRFTGIKYEDLQQPGYQFKTLYRTLAFSDVDVHNAIIDKSNCEQFL 611

  Fly   552 IHNIP------IGTE-----AVGNYTSSIPKAIRVYFGG-----------SKK----FVVTASRY 590
            :....      :|.:     ||..||   |.|.:::..|           .|:    |.|...:.
 Worm   612 LIEDKTAAMKLMGCDDPPKYAVKAYT---PDASQIFANGLHSQYRFYSSRGKRAVGLFGVNQKQV 673

  Fly   591 RSDTILTESSIRAKN-QLITVDSQQLALVMKQCSEAVKESDSIKNAITQTDNEFERLQAVAKDEQ 654
            ..:|:  |..:.|.| :||.:::..:.|:.|...|...|..:||:.|.:.|.:...|       |
 Worm   674 DEETL--EQELEAANRELIRLENHDIKLIEKTLRELTMERSTIKSTIDKLDKKTREL-------Q 729

  Fly   655 EKRRKLDQKIAHFNSLKTE-------------IETLQKKLEALRN-----SDSLDCLETNF---- 697
            .:|.|:|:.|..:.:..|:             :..||:||..|..     .|.||.|:..|
 Worm   730 YERVKIDRNINDWKADMTQCANTEQVDNINDALGELQEKLSILEEEAYCIQDKLDELDEKFQPAI 794

  Fly   698 -----------------------CNSLHKDLKKIFDADAELCSCLKAIDRLIIEKNMAQTKVSIY 739
                                   ..|..|.|:|: |.|.|            ..||
 Worm   795 KTKNESEKNYVELQQEVKGYAAQTLSFQKQLRKL-DEDGE------------AGKN--------- 837

  Fly   740 MLQHETQIEALKESEEQSKAATRDFQQLLQCLENQISDVNKRKSAIQ-GLCHGEIPTSSKFPFKK 803
                  :::.||.:|::   ...|..:|....:..::.|.|.|..|: .....:.|..|:||..|
 Worm   838 ------RLDKLKSNEDE---LYHDEARLKSERDEALNIVEKEKVTIERPRREADPPDLSEFPSTK 893

  Fly   804 EFRELENIDLPELREAIHDFQARLECMKSVNSEAISSYQGLQNEVKQLEEG---IQESVNQAKSI 865
            :.|:    .:.|:.:||....|  ||..:|   .|.|.:..:..:|:|.|.   ::|.|.:.:::
 Worm   894 DARK----KIIEMHKAISRDAA--ECGDTV---TIGSVKEFKENLKKLRESCRMLEEVVEEMQTV 949

  Fly   866 ESGMSNLY------------DKWE-----------------PKLNSLVETISTKFSEFMESIEYV 901
            .:|....|            ||::                 .|.|..|...|||..:.:...||
 Worm   950 HNGRLKAYPTLKKYTELKVTDKFKELLAIRGHFVGGLEFDHEKENLNVNVHSTKEKDALAGKEY- 1013

  Fly   902 GEVVLSKTDKYDFDSYGIQIMVQFRRGLQLQPLDKFIQ----------SGGERAVSIAIYSLSLQ 956
                 |.||:.:.|....     ::.|...:...|..:          |||||:...|...:||.
 Worm  1014 -----SSTDEDEDDEQEF-----YKNGKPKKKRSKKTKKKPVCDLKGLSGGERSFVTAALVMSLW 1068

  Fly   957 HVTHVPFRCVDEINQGMDATNERHIFDLLLKEATK---HGSAQYLFVTPKLLRDLN 1009
            .|...|||.:||.:..||..|.:.:.|||::.|||   |.  |::|.||:.:::||
 Worm  1069 EVMEQPFRMLDEFDVFMDMMNRKLVMDLLVEMATKKFPHN--QFIFFTPQGIKELN 1122

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	44/170 (26%)
		Smc	22..1011	CDD:224117	261/1205 (22%)
		GrpE	212..>316	CDD:295646	26/109 (24%)
		ABC_SMC5_euk	<919..1025	CDD:213244	32/104 (31%)
C23H4.6	NP_001257189.1	Smc	70..1116	CDD:224117	253/1175 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910