Protein Alignment SMC5 and mix-1

DIOPT Version :10

• Sequence 1: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_496331.1
• Gene: mix-1 / 174669
• WormBaseID: WBGene00003367
• Length: 1244
• Species: Caenorhabditis elegans
• Alignment Length: 1279
• Identity: 252/1279 - (19%)
• Similarity: 463/1279 - (36%)
• Gaps: 411/1279 - (32%)

  Fly    16 IHSVYCKDFVSYSEIT----FHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADY 76
            |.|::...|.||.:.|    |.|.  .|.:||.||||||.|:.:|...:|...:...|:.|:.:.
 Worm     3 IKSIHLDGFKSYQKHTDILDFSPT--FNAITGYNGSGKSNILDSICFIMGINKLDNIRAKSMHEL 65

  Fly    77 IQSNKTSATIIVRVYGRTPNTTETF----------RRIINS----NGLST-FSVNDKDTSKKNFL 126
            |....|.|.:.|| :..|......|          :|||.:    .|.:| :::|....:.....
 Worm    66 ISHGGTKAIVQVR-FDNTDKRCSPFGMEHLDEIVVQRIITAQATGKGCATSYTLNGHAATNGKMQ 129

  Fly   127 AAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANV-- 189
            .......:.|:|....:.|.|:.....|.|:|:|                    .|..|.|..
 Worm   130 DFFRGVGLNVNNPHFLIMQGRITTVLNMKPEEIL--------------------GMVEEAAGTKM 174

  Fly   190 --HANREKEKSDLVKKQK-----RLEHLQMTVSQYKEREEVKQKLQVYSAKKL------------ 235
              ...::.||:..:|..|     |:....:.....|.||:.|..::|...|||
 Worm   175 YDQKKKDAEKTMFLKDAKLKEVDRIFQSSIDPRMVKFREDRKNMVEVTRLKKLKENFSRKYEAFQ 239

  Fly   236 WVET-QAGEAKAAEMKTQVKNAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLEKTRLLENAV 299
            :.:| :|.:..|.|::...|..:...:|. ||.|..|:::|. ||:|       :|::|   :..
 Worm   240 YFQTCEAVKKSAKEIEDAKKGIEDLGEKF-NQLDLDLKNKED-EKKK-------MEESR---DDQ 292

  Fly   300 AEKAAIDGKMDSLKQGIYQKKYELEQNIKKSRRTATECDNLNQLVE--NKI-YELETLNKS---- 357
            .|:||:.....| ||.|..:|    :.:|            |||||  ||: .|.|.:|||
 Worm   293 HEEAALSAAHLS-KQSIMLQK----ETVK------------NQLVETINKLKKEGEQINKSLSKD 340

  Fly   358 RPLIVSELERAKESCAA-------------------------ARGKAMEQYSRRRQLEQKLN--- 394
            |.::.::.:..::|.||                         .||...........:|.::.
 Worm   341 REVLDAKRKEHEDSKAANSKDIQSQSDDEALVTKYRNDLESLTRGTIANDKGEHVSIESEIQSCK 405

  Fly   395 ---DEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMNWLAQNKQRYKLNVYDPMILELT 456
               .:|...|||.|.:.|||.|    :|..:..:...|          ..|.|.::.       :
 Worm   406 STASQMSSGITAAKKRGERLHN----QIKHLEGEKATL----------SARSKSDIG-------S 449

  Fly   457 VQNHEDAKFLENVVAQRDLFAF---ACEDKGDMSDLINELCVKQK-LGVNVIYCAPSDRLVYSPK 517
            ..|::  |.::.:..|..|..|   |..:|.:.:..::|...|.| :...::......|...:.:
 Worm   450 ADNYQ--KEVDEINKQLQLLGFNIDADTEKREHAAKLHESITKLKDMDTRLLNSYKDGRYALNYQ 512

  Fly   518 TP------IDDLRS-FGFRSYLVDLVTGPIPLINKLCASYSI-HNIPIGTEAVGNYTSSIPKAIR 574
            .|      .|:.|. ||:.::|:.:..|        |..::: .:|.:| ..:||...|.....|
 Worm   513 RPPLHIDKFDEKRDVFGYVAHLIKMKPG--------CEQFAVAADIALG-GVLGNVVVSTQDIAR 568

  Fly   575 VYFGG----SKKFVV-------TASRYR-----------------SDTI------------LTES 599
            :...|    |:|.::       .||.|.                 :||:            ::.:
 Worm   569 ILIDGKAFTSRKTMIPVSENARNASSYNTLPDVKLRRAKEIAEKYNDTVTKMIDLIEYPDFISNT 633

  Fly   600 SIRAKNQLITVDSQQLA------------LVMK-------------------------------- 620
            .:.|..|::.|||..:|            ::.:
 Worm   634 ILNAVGQILVVDSLDVAREIAYDEVAKTRMITRRGDDVRTNGIMTGGYNDPGNKPALIALEPMYA 698

  Fly   621 ---QCSEAVKESDSIKNAITQTDNEFERLQAVAKDEQEKRRKLDQKIAHFNS------------- 669
               |.....:|.|::...:..|:...::.:.:........|||.|...:.|:
 Worm   699 RRPQIEAQQRELDALNRELQLTEASSQKCRDLNNQLATAMRKLAQVKTNINNSEFGIVVRDLKVH 763

  Fly   670 ----------LKTEIETLQ------KKLEALRNSDSLDCLETNFCNSLHKDLKKIFDADAELCSC 718
                      ::..::||:      |.||:::|.|.         ||..|..|       ||.:.
 Worm   764 SEEYEKNQAEIEATVKTLKDVEDKIKTLESMKNKDK---------NSQEKRKK-------ELTAL 812

  Fly   719 LKAIDRLIIE-KNMAQ-TKVSIYMLQHETQ------------------------------IEALK 751
            |:..::.:.: ||..: .:..:.:||...:                              |.|||
 Worm   813 LQKAEQTVAQNKNRGEKARREVMLLQATVEEMEKTIKKDEGIWEQKKKECDELEEKLPNAIAALK 877

  Fly   752 ESEEQSKAATRDFQQLLQCLENQISDVNKRKSAIQGLCHGEIPTSSKFPFKKEFRELENIDLPEL 816
            ::|.:.|||    |..|..|:|....::.|...|...|...|...:|...|:|.:|.|...|.:
 Worm   878 DAELEQKAA----QAKLNDLKNNQRQISTRLGKIAKECDALIREKAKTKSKREEKEKELTSLQQ- 937

  Fly   817 REAIHDFQARLECMK---SVNSEA-------ISSYQGL-----QNEVKQLEEGIQ--------ES 858
            .||.:..:||.:..|   ..:.||       :..::|.     ::|:|:|.:.|:        ::
 Worm   938 SEASNRKEARSKLKKFEWLSDEEAHFNKKGGLYDFEGYTVSKGKDEIKELTDKIETLERSCCIQN 1002

  Fly   859 VNQAKSIESGMSNLYDKWE---PKLNSLVETIST----KFSEFMESIEYVGEVVLSKTDKYDF-- 914
            |:...:.|:.:.::.:|.|   ...|.|.:||:|    |..|.:.:.|.|.:         ||
 Worm  1003 VSNLDTCEAKVLDIKNKRERITEDFNMLKKTIATLDKKKVDELIRAHESVNK---------DFGQ 1058

  Fly   915 -------DSY-------------GIQIMVQFRRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVT 959
                   |::             |:::.|.| .|:....|.:.  |||:|::......|::....
 Worm  1059 IFNCLLPDAHASLVPPEGKTVCEGLEVKVSF-GGVVKDSLHEL--SGGQRSLVALSLILAMLKFK 1120

  Fly   960 HVPFRCVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVTPK 1003
            ..|...:||::..:|.::..:| .:::|....|.  |::.|:.|
 Worm  1121 PAPLYILDEVDAALDLSHTANI-GMMIKTHFHHN--QFIIVSLK 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	P-loop containing Nucleoside Triphosphate Hydrolases	14..>160	CDD:476819	42/162 (26%)
		SMC_N	22..>425	CDD:481474	111/481 (23%)
		SMC_prok_B	<193..1001	CDD:274008	204/1075 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<919..1025	CDD:476819	19/85 (22%)
mix-1	NP_496331.1	SMC_N	2..1182	CDD:481474	252/1279 (20%)