DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC5 and mix-1

DIOPT Version :9

Sequence 1:	NP_996141.2	Gene:	SMC5 / 326215	FlyBaseID:	FBgn0052438	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_496331.1	Gene:	mix-1 / 174669	WormBaseID:	WBGene00003367	Length:	1244	Species:	Caenorhabditis elegans

Alignment Length:	1279	Identity:	252/1279 - (19%)
Similarity:	463/1279 - (36%)	Gaps:	411/1279 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IHSVYCKDFVSYSEIT----FHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADY 76
            |.|::...|.||.:.|    |.|.  .|.:||.||||||.|:.:|...:|...:...|:.|:.:.
Worm     3 IKSIHLDGFKSYQKHTDILDFSPT--FNAITGYNGSGKSNILDSICFIMGINKLDNIRAKSMHEL 65

  Fly    77 IQSNKTSATIIVRVYGRTPNTTETF----------RRIINS----NGLST-FSVNDKDTSKKNFL 126
            |....|.|.:.|| :..|......|          :|||.:    .|.:| :::|....:.....
Worm    66 ISHGGTKAIVQVR-FDNTDKRCSPFGMEHLDEIVVQRIITAQATGKGCATSYTLNGHAATNGKMQ 129

  Fly   127 AAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANV-- 189
            .......:.|:|....:.|.|:.....|.|:|:|                    .|..|.|..
Worm   130 DFFRGVGLNVNNPHFLIMQGRITTVLNMKPEEIL--------------------GMVEEAAGTKM 174

  Fly   190 --HANREKEKSDLVKKQK-----RLEHLQMTVSQYKEREEVKQKLQVYSAKKL------------ 235
              ...::.||:..:|..|     |:....:.....|.||:.|..::|...|||
Worm   175 YDQKKKDAEKTMFLKDAKLKEVDRIFQSSIDPRMVKFREDRKNMVEVTRLKKLKENFSRKYEAFQ 239

  Fly   236 WVET-QAGEAKAAEMKTQVKNAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKALLEKTRLLENAV 299
            :.:| :|.:..|.|::...|..:...:|. ||.|..|:::|. ||:|       :|::|   :..
Worm   240 YFQTCEAVKKSAKEIEDAKKGIEDLGEKF-NQLDLDLKNKED-EKKK-------MEESR---DDQ 292

  Fly   300 AEKAAIDGKMDSLKQGIYQKKYELEQNIKKSRRTATECDNLNQLVE--NKI-YELETLNKS---- 357
            .|:||:.....| ||.|..:|    :.:|            |||||  ||: .|.|.:|||
Worm   293 HEEAALSAAHLS-KQSIMLQK----ETVK------------NQLVETINKLKKEGEQINKSLSKD 340

  Fly   358 RPLIVSELERAKESCAA-------------------------ARGKAMEQYSRRRQLEQKLN--- 394
            |.::.::.:..::|.||                         .||...........:|.::.
Worm   341 REVLDAKRKEHEDSKAANSKDIQSQSDDEALVTKYRNDLESLTRGTIANDKGEHVSIESEIQSCK 405

  Fly   395 ---DEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMNWLAQNKQRYKLNVYDPMILELT 456
               .:|...|||.|.:.|||.|    :|..:..:...|          ..|.|.::.       :
Worm   406 STASQMSSGITAAKKRGERLHN----QIKHLEGEKATL----------SARSKSDIG-------S 449

  Fly   457 VQNHEDAKFLENVVAQRDLFAF---ACEDKGDMSDLINELCVKQK-LGVNVIYCAPSDRLVYSPK 517
            ..|::  |.::.:..|..|..|   |..:|.:.:..::|...|.| :...::......|...:.:
Worm   450 ADNYQ--KEVDEINKQLQLLGFNIDADTEKREHAAKLHESITKLKDMDTRLLNSYKDGRYALNYQ 512

  Fly   518 TP------IDDLRS-FGFRSYLVDLVTGPIPLINKLCASYSI-HNIPIGTEAVGNYTSSIPKAIR 574
            .|      .|:.|. ||:.::|:.:..|        |..::: .:|.:| ..:||...|.....|
Worm   513 RPPLHIDKFDEKRDVFGYVAHLIKMKPG--------CEQFAVAADIALG-GVLGNVVVSTQDIAR 568

  Fly   575 VYFGG----SKKFVV-------TASRYR-----------------SDTI------------LTES 599
            :...|    |:|.::       .||.|.                 :||:            ::.:
Worm   569 ILIDGKAFTSRKTMIPVSENARNASSYNTLPDVKLRRAKEIAEKYNDTVTKMIDLIEYPDFISNT 633

  Fly   600 SIRAKNQLITVDSQQLA------------LVMK-------------------------------- 620
            .:.|..|::.|||..:|            ::.:
Worm   634 ILNAVGQILVVDSLDVAREIAYDEVAKTRMITRRGDDVRTNGIMTGGYNDPGNKPALIALEPMYA 698

  Fly   621 ---QCSEAVKESDSIKNAITQTDNEFERLQAVAKDEQEKRRKLDQKIAHFNS------------- 669
               |.....:|.|::...:..|:...::.:.:........|||.|...:.|:
Worm   699 RRPQIEAQQRELDALNRELQLTEASSQKCRDLNNQLATAMRKLAQVKTNINNSEFGIVVRDLKVH 763

  Fly   670 ----------LKTEIETLQ------KKLEALRNSDSLDCLETNFCNSLHKDLKKIFDADAELCSC 718
                      ::..::||:      |.||:::|.|.         ||..|..|       ||.:.
Worm   764 SEEYEKNQAEIEATVKTLKDVEDKIKTLESMKNKDK---------NSQEKRKK-------ELTAL 812

  Fly   719 LKAIDRLIIE-KNMAQ-TKVSIYMLQHETQ------------------------------IEALK 751
            |:..::.:.: ||..: .:..:.:||...:                              |.|||
Worm   813 LQKAEQTVAQNKNRGEKARREVMLLQATVEEMEKTIKKDEGIWEQKKKECDELEEKLPNAIAALK 877

  Fly   752 ESEEQSKAATRDFQQLLQCLENQISDVNKRKSAIQGLCHGEIPTSSKFPFKKEFRELENIDLPEL 816
            ::|.:.|||    |..|..|:|....::.|...|...|...|...:|...|:|.:|.|...|.:
Worm   878 DAELEQKAA----QAKLNDLKNNQRQISTRLGKIAKECDALIREKAKTKSKREEKEKELTSLQQ- 937

  Fly   817 REAIHDFQARLECMK---SVNSEA-------ISSYQGL-----QNEVKQLEEGIQ--------ES 858
            .||.:..:||.:..|   ..:.||       :..::|.     ::|:|:|.:.|:        ::
Worm   938 SEASNRKEARSKLKKFEWLSDEEAHFNKKGGLYDFEGYTVSKGKDEIKELTDKIETLERSCCIQN 1002

  Fly   859 VNQAKSIESGMSNLYDKWE---PKLNSLVETIST----KFSEFMESIEYVGEVVLSKTDKYDF-- 914
            |:...:.|:.:.::.:|.|   ...|.|.:||:|    |..|.:.:.|.|.:         ||
Worm  1003 VSNLDTCEAKVLDIKNKRERITEDFNMLKKTIATLDKKKVDELIRAHESVNK---------DFGQ 1058

  Fly   915 -------DSY-------------GIQIMVQFRRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVT 959
                   |::             |:::.|.| .|:....|.:.  |||:|::......|::....
Worm  1059 IFNCLLPDAHASLVPPEGKTVCEGLEVKVSF-GGVVKDSLHEL--SGGQRSLVALSLILAMLKFK 1120

  Fly   960 HVPFRCVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVTPK 1003
            ..|...:||::..:|.::..:| .:::|....|.  |::.|:.|
Worm  1121 PAPLYILDEVDAALDLSHTANI-GMMIKTHFHHN--QFIIVSLK 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	42/162 (26%)
		Smc	22..1011	CDD:224117	250/1273 (20%)
		GrpE	212..>316	CDD:295646	30/116 (26%)
		ABC_SMC5_euk	<919..1025	CDD:213244	19/85 (22%)
mix-1	NP_496331.1	Smc	1..1172	CDD:224117	252/1279 (20%)
		ABC_SMC2_euk	1..>157	CDD:213240	39/156 (25%)
		SMC_hinge	527..654	CDD:284001	25/135 (19%)
		TMPIT	765..>854	CDD:285135	18/104 (17%)
		P-loop_NTPase	<1086..1184	CDD:304359	19/82 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900