DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC5 and him-1

DIOPT Version :9

Sequence 1:	NP_996141.2	Gene:	SMC5 / 326215	FlyBaseID:	FBgn0052438	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_001040658.2	Gene:	him-1 / 172116	WormBaseID:	WBGene00001860	Length:	1262	Species:	Caenorhabditis elegans

Alignment Length:	1346	Identity:	257/1346 - (19%)
Similarity:	465/1346 - (34%)	Gaps:	464/1346 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGDRALSSKQLAGRIHSVYCKDFVSY-SEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEP 64
            |.|..:|.|....|.:|::..::|.|| .:.|..|......:.||||||||.::.||...||.:|
Worm     1 MRGGSSLDSFPGKGTLHTLEIENFKSYKGKHTIGPFTRFTAIIGPNGSGKSNLMDAISFVLGEKP 65

  Fly    65 ILLDRSASVADYIQS---NKTSA--TIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKN 124
            ..| |....||.|..   ||..|  ..:...|..:....:.|.|.:| ||.|...::.:..:...
Worm    66 SSL-RVRKYADLIHGAPINKPVAKKCRVTMNYKYSDGKVKAFTRGVN-NGTSEHLLDGQTVTSAA 128

  Fly   125 FLAAVSSFNI------------QVSNLCQFLPQDRVQDF-------------------------- 151
            :...:.|.||            .:.|:....|::|.|.|
Worm   129 YSQEMESINIFIKARNFLVYQGAIENIAMKTPKERTQLFEELSRSHEFQAEYERLKVEMTKAEDD 193

  Fly   152 -----------------SKMNPQE-----LLLNTMSSV-----------CDEDLINSFNSLKQMR 183
                             :||...|     .:.|.:::.           |:..:..|...:...:
Worm   194 TQHNMNKRRGIAQEKREAKMEKDEAEKYQTMKNELAAKSTMLFLHQLFHCERTIDESKEEINAQK 258

  Fly   184 TEQANVHANREKE----------------------------KSDLVKKQKRLEHLQMTVSQYKER 220
            ...|::.|.|.||                            ::||.:||:.:..|:::|:...::
Worm   259 KTIASLEATRSKEEAKIAAVHQEHRKALREVQKMTRKLDQKETDLAEKQQNMLTLKVSVAHEHKK 323

  Fly   221 EEVKQKLQVYSAKKLWVETQAGEAKAAEMKTQ---VKNAKTQSDKLKNQHDKLLQ---------- 272
            .|:.:|:           ..|.|:||....||   :|.:|.:.:|.|..::..:|
Worm   324 LEIAKKM-----------LAAAESKAENNSTQLADLKKSKKELEKKKAAYEAEIQDMMQRGELNL 377

  Fly   273 SQEQIE-----KEKESLRKALLEKTRLLENAVAEKAAIDGKMDSLKQGIYQKKYELEQNIKKS-- 330
            |.||:.     |::.....|::::..|:...|.|     |...||...:.::| |.::.:|..
Worm   378 SDEQVREYGQLKDQAQRESAMVQRELLMAEQVFE-----GDKSSLNHELRRQK-EHQERVKAKEG 436

  Fly   331 --RRTATECDNLNQLVENKIYELETLNKSRPLIVSELERAKESCAAARGKAMEQYSRR-----RQ 388
              ||..|:...|.|    :|.|.|...|   ::.::|::.:......:..|.| |::.     ||
Worm   437 DVRRIETQIATLAQ----RIKETEEETK---ILKADLKKIENDVVIDKSAAAE-YNKELVAVVRQ 493

  Fly   389 LEQKLNDEMIPEITAYKLKIERLRNVKMQKIDEIRAKNPNLVVAMNWLAQNKQRYKLNVYDPMIL 453
            |.:...|....|                        :|.....|:..|   |:.:..:||..::
Worm   494 LSEASGDSAEGE------------------------RNQRRTEALEGL---KKNFPESVYGRLV- 530

  Fly   454 ELTVQNHEDAKFLENVVAQRDLFAFACEDKGDMSDLINELCVKQKLGVNVIYC----------AP 508
            :|...:|:........:.|:.:.:..|:.:        |...|.     ::|.          .|
Worm   531 DLCQPSHKRFNIATTKILQKHMNSIVCDTE--------ETAAKA-----IVYLKDHRYPPETFLP 582

  Fly   509 SDRLVYSPKTPIDDLRSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGTEAVGNYTSSIPKAI 573
            :|.||.:|..  :.||.                 |.|          |.|.:.|.:..:...:|.
Worm   583 NDALVVNPLN--EKLRE-----------------IKK----------PAGVKLVFDVINPQHQAA 618

  Fly   574 R----------------------VYFGGSKKFVVTASRYRS----DTILTESSIRA--------- 603
            |                      .|.||..|     .|:::    .|:..:|.:.:
Worm   619 RKALQFVCGNALVCESQEDAKQLAYGGGELK-----DRFKAVSMDGTLFQQSGVMSGGSADLRQK 678

  Fly   604 ---------------KNQLITVDSQQLALVMKQCSEAVKESDSIKNAITQTDNEFERLQAVAKDE 653
                           :|||    ::::|.:.|.....: |.:|:::.|  ..|| :||..:.:|.
Worm   679 SKKWDEKVVKQLREKRNQL----NEKIADLQKHRRREL-EVESVRSKI--NGNE-QRLAMMKRDL 735

  Fly   654 QEKR--------RKLDQKIAHFNSLKTEIETLQKKLEALRNSDSLDCLET-----------NFCN 699
            :..|        .:|:...|..|.|...|...|:|||  |:..:|..|:|           :||.
Worm   736 KNMREMQLERLQNELEGMTAEMNMLPPRISNCQEKLE--RSESTLKSLQTKSNEVADRIFADFCT 798

  Fly   700 SL------------------HKDLKKIFDADAELCSC--------------------LKAIDRLI 726
            .:                  .:|..:.||.|.:..:.                    :..|||..
Worm   799 RVGIASIRDYENREMRIKQEMEDKLRSFDDDIQKLAYEIDFVTEQDGNRKVEVEKEKVSQIDRQY 863

  Fly   727 IEKNMAQTKVSIYMLQHETQIEALKESEEQSKA------------------ATRDF----QQLLQ 769
            .:....:...:..:.:|...:|..||..|:.||                  |.:||    ::||:
Worm   864 KDMKKKEKTAAAALKEHTESMEQDKEVLEEKKALSHKLETEWNEVKKIAQVAMKDFTKAEKELLR 928

  Fly   770 CLENQISDVN-KRKSAIQGLCHGEI--PTSSKFPFKKEFRELENIDLPELREAIHDFQARLECMK 831
             ||:.::... :|.|.:..:..|:|  |..|......|:.|.:..|     .|....|:..: ..
Worm   929 -LESLLTKKQYERHSLLHSVKLGQIALPLKSGSMADVEYEEDDGDD-----TASQSSQSATD-GP 986

  Fly   832 SVNSEAIS-------SYQGLQNEVKQL--EEGIQESVNQAK-SIESGMSNLYDKWEP--KLNSLV 884
            ||:.|.|.       :|..|..|.|.:  ::|:::..|:.. .|:....|:.....|  |.|..:
Worm   987 SVSEEQIQREQHIKINYDSLPREYKDVDDDDGVRQMSNRLNVEIDELQKNVSKMNAPNLKANQRM 1051

  Fly   885 ETISTKFSEFMESIEYVGEVVLS--------KTDKY----DF---------DSY----------- 917
            ..:..:.:|..|.:|...:....        |||:|    ||         |.|
Worm  1052 AEVKEREAESTEELENARKKAKRIRQQFEKVKTDRYRRFQDFFDPVANTIDDIYKQLSRNTSAQA 1116

  Fly   918 --GIQIM-------VQFR---RGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTH----VPFRCV 966
              |...|       :|:.   .|.:.:|:|..  ||||:.::    :|:|....|    .||..:
Worm  1117 FLGADNMEEPYLDGIQYNCVAPGKRFRPMDNL--SGGEKTIA----ALALLFAVHGRNPAPFFVL 1175

  Fly   967 DEINQGMDATNERHIFDLLLKEATKHGSAQYLFVTPKLLRDLNYNE 1012
            |||:..:|.||...:...:.:.|.:|  .|.:.::   |::..||:
Worm  1176 DEIDAALDNTNIGKVASYICESAREH--MQIIVIS---LKEEFYNK 1216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	46/211 (22%)
		Smc	22..1011	CDD:224117	249/1322 (19%)
		GrpE	212..>316	CDD:295646	25/121 (21%)
		ABC_SMC5_euk	<919..1025	CDD:213244	26/108 (24%)
him-1	NP_001040658.2	SMC_N	15..1232	CDD:280601	252/1332 (19%)
		ABC_SMC1_euk	16..>160	CDD:213242	38/145 (26%)
		Vps53_N	232..>334	CDD:282020	15/112 (13%)
		SMC_hinge	523..641	CDD:214944	23/160 (14%)
		ABC_SMC1_euk	<1137..1240	CDD:213242	24/91 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000