Protein Alignment SMC5 and Smc2

DIOPT Version :10

• Sequence 1: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_032043.3
• Gene: Smc2 / 14211
• MGIID: 106067
• Length: 1191
• Species: Mus musculus
• Alignment Length: 1243
• Identity: 238/1243 - (19%)
• Similarity: 447/1243 - (35%)
• Gaps: 396/1243 - (31%)

  Fly    16 IHSVYCKDFVSYSEIT----FHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADY 76
            :.|:..:.|.||::.|    |.|  ..|.:||.||||||.|:.:|...||...:...|::::.|.
Mouse     3 VKSIILEGFKSYAQRTEVNGFDP--LFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDL 65

  Fly    77 I----QSNKTSATIIVRV---------YGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFLAA 128
            :    |:..|.|::.:..         .|...:...|..|.:...|.:.:.:|..:.:.......
Mouse    66 VYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQDL 130

  Fly   129 VSSFNIQVSNLCQFLPQDRVQDFSKMNPQELL-----------------------------LNTM 164
            ..|..:.|:|....:.|.|:.....|.|.|:|                             |..:
Mouse   131 FCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEI 195

  Fly   165 SSVCDEDLINSFNSLKQMRT---EQANV-----HANR--------------EKEKSDLVKKQKRL 207
            .::.:|::..:...||:.|:   |...|     |.:|              |:...:|.:.|.::
Mouse   196 KTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLRAEDTKERSAGELKEMQDKI 260

  Fly   208 EHLQMTVSQYKER--------EEVKQKLQVYSAKKL-WVETQAGEAKAAEMKTQ------VKNAK 257
            .:||..:|:.:::        ||::::....:..|| .:|....||:....|:|      .||..
Mouse   261 VNLQEVLSENEKKIKALNCEIEELERRKDKETGGKLKSLEDACAEAQRVNTKSQSAFDLKKKNLA 325

  Fly   258 TQSDKLKNQHDKLLQSQEQI-EKEKE---------SLRKALLEKTRLLE------NAVA------ 300
            ::..|.|...:.:.:..:.: .||||         .|::|..:....|.      |||:
Mouse   326 SEETKRKELQNSMAEDSKALAAKEKEVKKITDGLHGLQEASNKDAEALAAAQQHFNAVSAGLSSN 390

  Fly   301 ---EKAAIDGKMDSLKQGIYQKKYELEQNIKKSRRTATECDNLNQLVE--NKIYE-----LETLN 355
               .:|.:.|:|.:.|..|.:.:.|.:|...|.:....|..:....|:  :..|:     .|.:.
Mouse   391 EDGAEATLAGQMIACKNDISKAQTEAKQAQMKLKHAQQELKSKQAEVKKMDSGYKKDQDAFEAVK 455

  Fly   356 KSRPLIVSEL-----ERAKESCAAARGKAMEQYSRRRQLEQKLNDEMIPEITAYKLKIERLRNVK 415
            |::..:.:|:     |..||.      |.:|::   |||.:.:|                  |:|
Mouse   456 KAKEKLETEMKKLNYEENKEE------KLLEKH---RQLSRDIN------------------NLK 493

  Fly   416 MQKIDEIRAKNPNLVVA-----MNWLAQNKQRYK------LNVYD---PMILELTVQNHEDAKFL 466
             .|.:.:.||.|||..|     .||   |:...|      :||.|   ...||:..     .:.|
Mouse   494 -GKHEALLAKFPNLQFAYKDPEKNW---NRNSVKGLVASLINVKDNSTATALEVVA-----GERL 549

  Fly   467 ENVVAQRDLFAFACEDKGDMS--------DLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDL 523
            .|||...::.|....:||::.        :.|:..|:                   :|:|    |
Mouse   550 YNVVVDTEVTAKKLLEKGELKRRYTIIPLNKISARCI-------------------APET----L 591

  Fly   524 RSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFG--------GS 580
            |       :...:.||             .|:.:....| :|...:.|.:...||        .:
Mouse   592 R-------VAQNLVGP-------------DNVHVALSLV-DYKPELQKGMEFVFGTTFVCNNMDN 635

  Fly   581 KKFVVTASRYRSDTILTESSIRAKNQLIT--VDSQQLALVMKQCSEAVKESDSIKNAITQTDNEF 643
            .|.|....|..:.|:.....:...:..::  ..||..:::.|     .:|...:::.:...:||.
Mouse   636 AKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTK-----FQEVKDVQDELRTKENEL 695

  Fly   644 ERLQ---AVAKDEQEKRRKLDQKIAHFNSLKTEI-ETLQKKLEALRNSDSLDCLETNFCNSLHKD 704
            ..|:   |..|:..||.|:|.|:.    .:|||. :.||.||:.               :|.||.
Mouse   696 RALEEELAGLKNVAEKYRQLKQQW----EMKTEEGDLLQTKLQQ---------------SSYHKQ 741

  Fly   705 ------LKKIFDADAELCSCLKAIDRLIIEKNMAQTKVSIYMLQHETQIEALKESEEQSKAATRD 763
                  |||..:...|.....|.|.:...||             :|.....:|.:|.:.:...:|
Mouse   742 QEELDALKKTIEESEETLKSTKEIQKKAEEK-------------YEALENKMKNAEAEREKELKD 793

  Fly   764 FQQLLQCLENQISDVNKRKSAIQGLCHGEIPTSSKFPFKKEFRELENIDLPELREAIHDFQARLE 828
            .|:.|.|.:.: :|.:.:|                  .|::.:|:|.|.| ||.|...:..:..:
Mouse   794 AQKKLDCAKTK-ADASSKK------------------MKEKQQEVEAITL-ELEELKREHASNEQ 838

  Fly   829 CMKSVNSEAISSYQGLQNEVKQLEEGI---QESVNQA-------KSIESGMSNLY-DKW------ 876
            .:.:|| |||.:|:|   :::::...:   :||||:|       |.|.:...|:. ||.
Mouse   839 QLDAVN-EAIKAYEG---QIEKMAAEVAKNKESVNKAQDELMKQKQIITAQDNIIKDKCAEVAKH 899

  Fly   877 -------EPKLNSLVETIS----------TKFSEFMESIEYVG---EVVLSKTDKYDFDSYGIQI 921
                   :.|:..|..:||          .|.|:.:...:::.   .:.......|||.:...:
Mouse   900 NLQNNESQLKIKELDHSISKHKREADDAAAKVSKMLSDYDWINAEKHLFGQPNSAYDFKTNNPK- 963

  Fly   922 MVQFRRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLL 986
                ..|.:||.|.:..:..|.                :|..|.::.:.:..:..|     ||:.
Mouse   964 ----EAGQRLQKLQEVKEKLGR----------------NVNLRAMNVLTEAEERYN-----DLMK 1003

  Fly   987 KEATKHGSAQYLFVTPKLLRDLNYNEHLCVSIV-------------------------HNSKTVC 1026
            |:.........:..|   :.||:..::..::|.                         ...:||.
Mouse  1004 KKRIVENDKSKILAT---IEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVL 1065

  Fly  1027 HGMQFPMA 1034
            .|::|.:|
Mouse  1066 DGLEFKVA 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	P-loop containing Nucleoside Triphosphate Hydrolases	14..>160	CDD:476819	38/160 (24%)
		SMC_N	22..>425	CDD:481474	102/522 (20%)
		SMC_prok_B	<193..1001	CDD:274008	182/952 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<919..1025	CDD:476819	15/130 (12%)
Smc2	NP_032043.3	SMC_N	2..1167	CDD:426784	238/1243 (19%)