DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC5 and Smc1b

DIOPT Version :9

Sequence 1:	NP_996141.2	Gene:	SMC5 / 326215	FlyBaseID:	FBgn0052438	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_536718.1	Gene:	Smc1b / 140557	MGIID:	2154049	Length:	1248	Species:	Mus musculus

Alignment Length:	1269	Identity:	244/1269 - (19%)
Similarity:	442/1269 - (34%)	Gaps:	414/1269 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GRIHSVYCKDFVSY-SEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYI 77
            |.:..:..::|.|: ......|......:.||||||||.::.|:...:|.:...| |..::.:.|
Mouse     2 GHLELLLVENFKSWRGRQVIGPFKRFTCIIGPNGSGKSNVMDALSFVMGEKTTNL-RVKNIQELI 65

  Fly    78 Q--------SNKTSATIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFLAAVSSFNI 134
            .        |:..|.|||   |.......:||.|||. .|.|.:...||..|:..::|.:.:..|
Mouse    66 HGAHTGKPVSSSASVTII---YIEDSGEEKTFTRIIR-GGCSEYHFGDKPVSRSVYVAQLENIGI 126

  Fly   135 ------------QVSNLCQFLPQDRVQDFSKMNPQELLLNTMSS------VCDEDLINSFNSLKQ 181
                        .|.::....|::|.|.|.:::.....:....:      ..:||....||..|.
Mouse   127 IVKAQNCLVFQGTVESISMKKPKERTQFFEEISTSGEFIGEYEAKKKKLQKAEEDAQFHFNVKKN 191

  Fly   182 MRTEQANVHANREKEKSDLVK---KQKRLEHLQMTVSQYKEREE------------------VKQ 225
            :..|:.  ||..|||:::..:   ::.::..:|:.:.|....||                  ||.
Mouse   192 VAAERK--HAKIEKEEAEHYQNLLEELKINKIQLMLFQLYYNEEKINVLNTELEQMDGNLSVVKD 254

  Fly   226 KL----QVYSAKK-------LWVETQAGEAKAAE------------------------------M 249
            .|    .::.|||       ..::..|.|.|:.|                              :
Mouse   255 TLSHHENIFKAKKKDYGMLTRQLQQTAKELKSVEAILNQKRPQYIKAKENTSHHLKKLDLSKKLI 319

  Fly   250 KTQVKNAKTQSDKL------------------KNQHDKLLQSQEQIEKE----------KESLRK 286
            ....|....|.|.:                  |...:|:||....||.|          ||.:|:
Mouse   320 TDNEKQCSKQEDGIRALVAELADLDRAWKSFEKQMEEKILQKGRDIELENSQLDRYKLLKEQVRR 384

  Fly   287 AL------LEKTRLLENAVAEKAAID--------GKMDSLKQGIYQKKYELEQNIKKSRRTATEC 337
            .:      |||.:..:.|..|:.|.:        |.:..:|:.|.:.|..:|: :::..:|..:|
Mouse   385 KVGIMTQQLEKLQWEQKAEKERLAFEKRRHGDTQGNLKQIKEQIEEHKKRIEK-LEEYTKTCMDC 448

  Fly   338 --------DNLNQLVENKIYELETLNKSRPLIVSELERAKESCAAARGKAMEQYSRRRQLEQ--- 391
                    :.|.:.:||....:..:|:...||.:||:.|    .....:...|..|...||.
Mouse   449 LEDKKQQEEALKKEIENTKSRMSEVNEELSLIRNELQNA----GIDNHEGKRQQKRAEVLEHLKR 509

  Fly   392 --------KLNDEMIPEITAYKLKI---------------------------------------- 408
                    :|.|...|....|:|.:
Mouse   510 LYPDSVFGRLLDLCHPIHKKYQLAVTKLFGRYMVAIVVASEKIAKDCIRFLKAERAEPETFLALD 574

  Fly   409 --------ERLRNVKMQK--IDEIRAKNPNLVVAMNWLAQNKQRYKLNVYDPMILELTVQNHEDA 463
                    ||||.:|..|  ||.|:.:.|.|...:.::..|              .|..:..|:|
Mouse   575 YLDIKPINERLREIKGCKMMIDVIKTQFPQLKKVIQFVCGN--------------GLVCETVEEA 625

  Fly   464 KFL--------ENVVAQRDLFAFACEDKGDMSDLINE-LCVKQKLGVNVIYCAPSDRLVYSPKTP 519
            :.:        :.|.....||..:....|..|||.:: ||..:|                    .
Mouse   626 RHIAFGGPERRKAVALDGTLFLKSGVISGGSSDLKHKALCWDEK--------------------E 670

  Fly   520 IDDLRSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGGSKKFV 584
            :.:||.  .||.||..:...:..:.|......|..:..||.....|:.:..:.|:      ||.:
Mouse   671 LHNLRD--KRSQLVQELKELMKTLRKETDLKQIQTLVQGTNTRLKYSQNELEMIK------KKHL 727

  Fly   585 VTASRYRSDTILTESSIRAKNQLITVDSQQLAL---VMKQ---CSEAVKESDSIKNAITQ----- 638
            .|..|.:|         :.:::|:.:|||...|   :.||   ..|...:.|.:::.|.|
Mouse   728 ATFYREQS---------QLQSELLNIDSQCTMLSEGINKQQQKIEEFQDKIDEVEDDIFQDFCEE 783

  Fly   639 --TDN--EFERLQAVAKDEQEKRRKLDQKIAHFNSLKTEIETLQKKLEALRNS-----DSLDCLE 694
              .:|  |||...  .|.:||.    |||...|...||.   |..:||..||.     :::|.|:
Mouse   784 IGVENIREFENKH--VKQQQEN----DQKRLEFEKQKTR---LNIQLEYSRNQLKKKLNNIDTLK 839

  Fly   695 TNFCNSLHKDLKKIFDADAELCSCLKAIDRLIIEKNMAQTKVSIYMLQHETQIEALK-ESEEQSK 758
            |..... .:|:..:...:.|   |||.::.|:::    |.::...:....:.||.:. :.||:.|
Mouse   840 TTIQKG-KEDIDNLKKTEEE---CLKIVEELMVK----QEQIKEVLATQSSNIEKIHIQIEEERK 896

  Fly   759 AATRDFQQLLQCLENQISDVNKRKSAIQGLCHGEIPTSSKFPFKKEFR---ELENIDLPELREAI 820
            .        :..::.::..:.|....|||      ....|...|....   ::::||:..:..::
Mouse   897 K--------VLAVDREVGKLQKEVVIIQG------SLEQKLLEKHNLLLDCKVQDIDISLVLGSL 947

  Fly   821 HDFQARLECMKSVNSEAIS-----------SYQGLQNEVKQLEEGIQESVNQAKSIESGMSNLYD 874
            .|. ..:|..::.:::|.:           .|..|:.::|.|:..        |.:|:.::.|..
Mouse   948 EDI-IEMELTETESTQATADIYEKEASIQIDYSPLREDLKALQSD--------KEVEAHLTLLLQ 1003

  Fly   875 KWEPKLNSLVET----------ISTKFSEFMESIEYV-----------GEVVLSKTDKYD----- 913
            :...:.|:|::|          :.|...:|.||.:..           .|....|..:||
Mouse  1004 QVASQENTLLKTTAPNLRAQENLKTVRDKFQESADVFEASRKEARICRQEFEQVKRRRYDAFSQC 1068

  Fly   914 FDSYGIQIMVQFRR-------------------------------GLQLQPLDKFIQSGGERAVS 947
            |:...:.|...:::                               |.:..|:|..  ||||:.|:
Mouse  1069 FEHISVSIDQIYKKLCRNNSAQAFLSPENPEEPYLDGISYNCVAPGKRFMPMDNL--SGGEKCVA 1131

  Fly   948 IAIYSLSLQHVTH----VPFRCVDEINQGMDATN 977
                :|:|....|    .||..:||::..:|.||
Mouse  1132 ----ALALLFAVHSFRPAPFFVLDEVDAALDNTN 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	40/166 (24%)
		Smc	22..1011	CDD:224117	243/1261 (19%)
		GrpE	212..>316	CDD:295646	34/204 (17%)
		ABC_SMC5_euk	<919..1025	CDD:213244	19/94 (20%)
Smc1b	NP_536718.1	Smc	3..1199	CDD:224117	243/1268 (19%)
		ABC_SMC1_euk	4..>148	CDD:213242	35/148 (24%)
		DUF342	<421..492	CDD:302792	15/75 (20%)
		SMC_hinge	513..628	CDD:214944	20/128 (16%)
		ABC_SMC1_euk	<1112..1215	CDD:213242	18/56 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1219..1248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900