Protein Alignment SMC5 and SMC2

DIOPT Version :9

• Sequence 1: NP_996141.2
• Gene: SMC5 / 326215
• FlyBaseID: FBgn0052438
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_001036015.1
• Gene: SMC2 / 10592
• HGNCID: 14011
• Length: 1197
• Species: Homo sapiens
• Alignment Length: 1227
• Identity: 243/1227 - (19%)
• Similarity: 453/1227 - (36%)
• Gaps: 364/1227 - (29%)

  Fly    16 IHSVYCKDFVSYSEIT----FHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADY 76
            |.|:..:.|.||::.|    |.|  ..|.:||.||||||.|:.:|...||...:...|::::.|.
Human     3 IKSIILEGFKSYAQRTEVNGFDP--LFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDL 65

  Fly    77 I----QSNKTSATIIVRV---------YGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFLAA 128
            :    |:..|.|::.:..         .|...:...|..|.:...|.:.:.:|..:.:.......
Human    66 VYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGVNANNTRVQDL 130

  Fly   129 VSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANVHANR 193
            ..|..:.|:|....:.|.|:.....|.|.|:|     |:.:|       :......|...:.|.:
Human   131 FCSVGLNVNNPHFLIMQGRITKVLNMKPPEIL-----SMIEE-------AAGTRMYEYKKIAAQK 183

  Fly   194 EKEKSDLVKKQKR----------LEHLQMTVSQYKEREEVKQKLQVYSAKKLWVETQAGEAKAAE 248
            ..||.:...|:.:          ::.|:...|.|.|.::|.::::..|  :|::..|...|:
Human   184 TIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLS--RLYIAYQFLLAE--- 243

  Fly   249 MKTQVKNAKTQSDKLKNQHDKLLQSQEQIEKEKESLRKAL------LEK---------TRLLENA 298
             .|:|::|    ::||...||:::.||::.:..:.: |||      |||         .|.||:|
Human   244 -DTKVRSA----EELKEMQDKVIKLQEELSENDKKI-KALNHEIEELEKRKDKETGGILRSLEDA 302

  Fly   299 VAEKAAIDGK----MDSLKQGI---YQKKYELEQNIKKSRRT--ATE------CDNLNQLVENKI 348
            :||...::.|    .|..|:.:   ..|:.|||:|:.:..:|  |.|      .|.|:.|.|...
Human   303 LAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASN 367

  Fly   349 YELETL------------------NKSRPLIVSELERAKESCAAARGKAMEQYSRRRQLEQKLND 395
            .:.|.|                  :.:...:..::...|...:.|:.:|.:...:.:..:|:|.:
Human   368 KDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKN 432

  Fly   396 EMIPEI----TAYKLKIERLRNVK---------MQKIDEIRAKNPNLVVAMNWLAQNKQRYKLNV 447
            :. .|:    :.|:...|.|..||         |:|::....|..:|:.....|:::..|.| ..
Human   433 KQ-AEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLK-ET 495

  Fly   448 YDPMILELTVQNHEDAKFLENVVAQRDLFAFACED----------KGDMSDLINELCVKQKLGVN 502
            |:.::          |:|..        ..||.:|          ||.::.||:   ||......
Human   496 YEALL----------ARFPN--------LRFAYKDPEKNWNRNCVKGLVASLIS---VKDTSATT 539

  Fly   503 VIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVDL-VTGP--------------IPLINKLCA-SYS 551
            .:.....:||.                :.:||. |||.              ||| ||:.| ..:
Human   540 ALELVAGERLY----------------NVVVDTEVTGKKLLERGELKRRYTIIPL-NKISARCIA 587

  Fly   552 IHNIPIGTEAVG-----------NYTSSIPKAIRVYFG--------GSKKFVVTASRYRSDTILT 597
            ...:.:....||           .|...:.||:...||        .:.|.|....|..:.|:..
Human   588 PETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTL 652

  Fly   598 ESSIRAKNQLIT--VDSQQLALVMKQCSEAVKESDSIKNAITQTDNEFERLQ---AVAKDEQEKR 657
            ...:...:..::  ..||..:::.|     .:|...:::.:...:||...|:   |..|:..||.
Human   653 GGDVFDPHGTLSGGARSQAASILTK-----FQELKDVQDELRIKENELRALEEELAGLKNTAEKY 712

  Fly   658 RKLDQKIAHFNSLKT-EIETLQKKLEALRNSDSLDCLETNFCNSLHKD------LKKIFDADAEL 715
            |:|.|:.    .:|| |.:.||.||:.               :|.||.      |||..:...|.
Human   713 RQLKQQW----EMKTEEADLLQTKLQQ---------------SSYHKQQEELDALKKTIEESEET 758

  Fly   716 CSCLKAIDRLIIEKNMAQTKVSIYMLQHETQIEALKESEEQSKAATRDFQQLLQCLENQISDVNK 780
            ....|.|.|...||             :|.....:|.:|.:.:...:|.|:.|.|.:.: :|.:.
Human   759 LKNTKEIQRKAEEK-------------YEVLENKMKNAEAERERELKDAQKKLDCAKTK-ADASS 809

  Fly   781 RKSAIQGLCHGEIPTSSKFPFKKEFRELE--NIDLPELR--------------EAIHDFQARLEC 829
            :|                  .|::.:|:|  .::|.||:              |||..:::::|.
Human   810 KK------------------MKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEV 856

  Fly   830 MKSVNSEAISSYQGLQNEVKQLEEGI--QESVNQAKSIE-------SGMSNLYDKWEPKLNSLVE 885
            |.:..::...|....|.||.:.:|.|  |::|.:||..|       :..|.|      |:..|..
Human   857 MAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQL------KIKELDH 915

  Fly   886 TIS----------TKFSEFMESIEYVG---EVVLSKTDKYDFDSYGIQIMVQFRRGLQLQPLDKF 937
            .||          .|.|:.::..:::.   .:.......|||.:...:     ..|.:||.|.:.
Human   916 NISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPK-----EAGQRLQKLQEM 975

  Fly   938 IQSGGERAVSIAIYSLSLQHVTHVPFRCVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVTP 1002
            .:..|.                :|..|.::.:.:..:..|     ||:.|:.........:..|
Human   976 KEKLGR----------------NVNMRAMNVLTEAEERYN-----DLMKKKRIVENDKSKILTT- 1018

  Fly  1003 KLLRDLNYNEHLCVSIV-------------------------HNSKTVCHGMQFPMA 1034
              :.||:..::..::|.                         ...:||..|::|.:|
Human  1019 --IEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVA 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	39/160 (24%)
		Smc	22..1011	CDD:224117	235/1171 (20%)
		GrpE	212..>316	CDD:295646	32/122 (26%)
		ABC_SMC5_euk	<919..1025	CDD:213244	15/130 (12%)
SMC2	NP_001036015.1	Smc	1..1168	CDD:224117	243/1227 (20%)
		ABC_SMC2_euk	1..>172	CDD:213240	42/182 (23%)
		Uds1	<193..287	CDD:292096	24/104 (23%)
		L_lactis_ph-MCP	252..>465	CDD:115336	46/214 (21%)
		SMC_hinge	522..639	CDD:214944	27/136 (20%)
		DUF342	<636..777	CDD:302792	38/177 (21%)
		DUF4200	740..841	CDD:290574	25/132 (19%)
		P-loop_NTPase	<1074..1168	CDD:304359	243/1227 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810