DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC5 and smc5

DIOPT Version :9

Sequence 1:	NP_996141.2	Gene:	SMC5 / 326215	FlyBaseID:	FBgn0052438	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	XP_017944874.1	Gene:	smc5 / 100485531	XenbaseID:	XB-GENE-953072	Length:	1086	Species:	Xenopus tropicalis

Alignment Length:	1099	Identity:	317/1099 - (28%)
Similarity:	533/1099 - (48%)	Gaps:	131/1099 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GDRALSSKQ------LAGRIHSVYCKDFVSYSEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLG 61
            |.:.|..:|      :.|.|..:..::|::|......|..:||::.|.||:|||:||.||.|||.
Frog    12 GTKLLLGRQGHNRNLVEGSITRIKMENFLTYDHCEVFPGPHLNMIVGANGTGKSSIVCAICLGLA 76

  Fly    62 GEPILLDRSASVADYIQSNKTSATIIVRVYGRTPNTTETFRRIINSNGLSTFSVNDKDTSKKNFL 126
            |:...:.|:..|..|::.......:.:.:|..:.|.| ..|.|..:|..|.:.:|.|:.:.|...
Frog    77 GKTAFIGRADKVGFYVKRGCQKGFVELELYKASGNVT-IKREIQVANNQSVWYINHKNATLKMVE 140

  Fly   127 AAVSSFNIQVSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLKQMRTEQANVHA 191
            ..|::.||||.|||||||||:|.:|:|::..|||..|..||...::......||..|.::..:.:
Frog   141 EQVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSVGTPEMYKFHCELKNCREKEKELES 205

  Fly   192 NREKEKSDLVKKQKRLEHLQMTVSQYKEREEVKQKLQVYSAKKLWVETQAGEAKAAEMKTQVKNA 256
            ..:.:...|.|..:|.|..:..|.:|.:::..:.|:.:...|:.|||.:....:..|:|.:..|.
Frog   206 ACKSKAEFLEKLNQRNERNKQEVERYYQQKRHQDKIDMLERKRPWVEYENVRQQYEEVKKRCNNI 270

  Fly   257 KTQSDKLKNQHDKLLQSQEQIEKEKESL-----RKA--LLEKTRLLENAVAEKAAIDGKMDSLKQ 314
            |.:..||:.....|.|..:||||.:.::     .||  :.|.:|..:....|....|.|::.::|
Frog   271 KDELKKLQELQAPLNQKIQQIEKRQRAIDEKIKNKAVEIKETSRNCKQKQDELEQKDKKIEEVQQ 335

  Fly   315 GIYQKKYELEQNIKKSRRTATECDNLNQLVENKIYELETLNKSRPL------IVSELERAKESCA 373
            .:..|:.|.:...||       ..|:.:::|:...||.|:.....|      |.::|...:...|
Frog   336 ALRMKRDEEQDRQKK-------IGNIRKMIEDWKKELGTMTNQENLQPEMDSITTDLRHIQNEKA 393

  Fly   374 AARGK----AMEQYSRRRQLEQKLNDEMIPEITAYKLK-IERLRNVKMQKIDEIRAKNPNLVVAM 433
            ....:    .||:..:.|:.:.|.|          ::| .:.|.|.|.:|:..:.....|.||
Frog   394 NIESEMSDLRMERDIQEREKKDKAN----------RIKQFDNLMNFKEEKLKRMFTDTYNAVV-- 446

  Fly   434 NWLAQNKQRYKLNVYDPMILELTVQNHEDAKFLENVVAQRDLFAFACEDKGDMSDLINELCVKQK 498
             ||.:||.|:|..|..||:||:.:::...||::||.::..|:.||..|.|.||...:.|:..|||
Frog   447 -WLKENKDRFKKRVCQPMMLEINMRDQYHAKYVENHISMNDMKAFVFESKEDMEVFLREVRDKQK 510

  Fly   499 LGVNVIYCAPSDRLVYS---PKTPIDDLRSFGFRSYLVDLVTGPIPLINKLCASYSIHNIPIGTE 560
            |.||.: |:|.:  .|:   |..||.||:.:||.|||.:|...|.|::|.||..|::|::|:|||
Frog   511 LRVNTV-CSPEE--PYATRRPTRPISDLQQYGFFSYLRELFDAPDPVMNYLCYQYNVHDVPVGTE 572

  Fly   561 AVGNYTSSIPKAI-----RVYFGGSKKFVVTASRYRSDTILTESSIRAKNQL-ITVDSQQLALVM 619
            ..   .|.|.|.|     |..:...:|:....|.|....|.:..|::....| :|||:::...|.
Frog   573 QT---RSMIEKVIQETKLRHMYTAEEKYTTKTSVYSQKLISSNVSLKGAQFLTVTVDAEERRQVE 634

  Fly   620 KQCSEAVKESDSI----------KNAITQTDNEFERLQAVAKDEQEKRRKLDQKIAHFNSLKTEI 674
            :|..|..::..|:          :..:.:.|||....:....|.:.|:::|:|:|:      |:.
Frog   635 EQLKEIQRKCSSLDASMGQLTERQRLLDRRDNELRMRKKEISDMKIKKKQLEQRIS------TKY 693

  Fly   675 ETLQKKLEALRNSDSLDCLETNFCNSLHKDLKKIFDADAELCSCLKAIDRLIIEKN---MAQTKV 736
            ::| |:||    .|:|:..|..  ......:|.|....|:|..     |.|::.|.   ::..||
Frog   694 DSL-KQLE----QDNLNVEEVE--QQAENKIKNINVQKAKLVK-----DLLLLMKKCTLLSIEKV 746

  Fly   737 SIYMLQHETQIEALKESEEQSKAATRDFQQLLQCLENQISDVNKRKSAIQGLCHG---------- 791
            .: .||..|......:.|...|.||...::    |:||...::.:|..:...|.|
Frog   747 EL-ALQSTTVSSEKNKIESDYKNATSQLRE----LKNQFDGIDAKKCMLLENCKGLLKKARQACN 806

  Fly   792 -----EIP----TSSKFPF---------------KKEFRELENIDLPELREAIHDFQARLECMKS 832
                 |:|    |:|:..:               .|.|:.|.: .|.|:...:::.:.|..|...
Frog   807 LGQNQEVPQDFQTTSRLEYSHLLEILDRIMNNDGSKAFQALPD-SLDEIDAMLNEERTRASCFTG 870

  Fly   833 VNSEAISSYQGLQNEVKQLEEGIQESVNQAKSIESGMSNLYDKWEPKLNSLVETISTKFSEFMES 897
            :.:..:..|.....|:|::...:.....:.::....:|.:.:||...|..|||.|:.:||.|..|
Frog   871 LTASVVEDYNKRTKEIKEVTAELDRKKLELENYRQNISQVKEKWLNPLRQLVEKINDQFSSFFSS 935

  Fly   898 IEYVGEVVLSKTDKYDFDSYGIQIMVQFRRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHVTHVP 962
            ::.||||.|...::.|:|.|||:|.|:||...||..|....||||||:||..:|.::||.:...|
Frog   936 MQCVGEVDLHTENEEDYDKYGIRIRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCP 1000

  Fly   963 FRCVDEINQGMDATNERHIFDLLLKEATKHGSAQYLFVTPKLLRDLNYNEHLCVSIVHN 1021
            ||.|||||||||..|||.:|::::|.|.|..::||.|:|||||::|.|.|.:.|..|:|
Frog  1001 FRVVDEINQGMDPVNERRVFEMVVKTACKENTSQYFFITPKLLQNLTYAEKMTVLFVYN 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	52/145 (36%)
		Smc	22..1011	CDD:224117	307/1062 (29%)
		GrpE	212..>316	CDD:295646	27/110 (25%)
		ABC_SMC5_euk	<919..1025	CDD:213244	52/103 (50%)
smc5	XP_017944874.1	Smc	31..1041	CDD:224117	303/1060 (29%)
smc5	XP_017944874.1	ABC_SMC5_euk	<961..1063	CDD:213244	50/99 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	267	1.000	Domainoid score	I1849
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41009
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1761
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D100993at2759
OrthoFinder	1	1.000	-	-		FOG0004754
OrthoInspector	1	1.000	-	-		oto105112
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3345
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060