DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32344 and DDX54

DIOPT Version :9

Sequence 1:	NP_612028.4	Gene:	CG32344 / 326208	FlyBaseID:	FBgn0052344	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_001104792.1	Gene:	DDX54 / 79039	HGNCID:	20084	Length:	882	Species:	Homo sapiens

Alignment Length:	874	Identity:	366/874 - (41%)
Similarity:	509/874 - (58%)	Gaps:	129/874 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IPGFPSLDNDAGTSDRGAD----ILKSKSKKNKSGGFQSMGLGFELIKGITKRGYKVPTPIQRKT 69
            :|.||:.:   .|||...|    :.....||.||||||||||.:.:.|||.|:||||||||||||
Human    65 LPTFPTSE---CTSDVEPDTREMVRAQNKKKKKSGGFQSMGLSYPVFKGIMKKGYKVPTPIQRKT 126

  Fly    70 IPLILEGRDVVAMAKTGSGKTACFLIPLFEKLQRREPTKGARALILSPTRELAVQTYKFIKELGR 134
            ||:||:|:||||||:||||||||||:|:||:|:......||||||||||||||:||.||.||||:
Human   127 IPVILDGKDVVAMARTGSGKTACFLLPMFERLKTHSAQTGARALILSPTRELALQTLKFTKELGK 191

  Fly   135 FMELKSILVLGGDSMDSQFSAIHTCPDVIVATPGRFLHLCVEMDLKLNSIEYVVFDEADRLFEMG 199
            |..||:.|:||||.|:.||:|:|..||:|:|||||.:|:.|||.|||.|:|||||||||||||||
Human   192 FTGLKTALILGGDRMEDQFAALHENPDIIIATPGRLVHVAVEMSLKLQSVEYVVFDEADRLFEMG 256

  Fly   200 FGEQLNETLHRLPSSRQTVMFSATLPKLLVEFARAGLNDPVLIRLDVESKLPDALALKFLYCRPD 264
            |.|||.|.:.|||...|||:|||||||||||||||||.:||||||||::||.:.|...|...|.|
Human   257 FAEQLQEIIARLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIRLDVDTKLNEQLKTSFFLVRED 321

  Fly   265 DRYTALVVLLKYVIPVQSQTVVFAGTQHHVELISYILTEAGISNASVYSSLDPAARKINTAKFVN 329
            .:...|:.||..|:..|.|||||..|:||.|.::.:||...:|.|.:||:|||.|||||.|||..
Human   322 TKAAVLLHLLHNVVRPQDQTVVFVATKHHAEYLTELLTTQRVSCAHIYSALDPTARKINLAKFTL 386

  Fly   330 KKVSVLIVTDVAARGIDIPSLDFVVNLHFPGKPKLFVHRVGRCARAGRTGTAYSIVSTDDTAHLL 394
            .|.|.|||||:||||:|||.||.|:|..||.|.|||:|||||.|||||:|||||:|:.|:..:||
Human   387 GKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSLVAPDEIPYLL 451

  Fly   395 DLHLFLNRPFNIHD-----------SSALGTIPQDLLEEEHLTV-TDIKKSHHIAGVLRTSENAY 447
            ||||||.|...:..           ...||.:||.:::||...: :.::.|..:.|:.|.::||.
Human   452 DLHLFLGRSLTLARPLKEPSGVAGVDGMLGRVPQSVVDEEDSGLQSTLEASLELRGLARVADNAQ 516

  Fly   448 KKYLSSRPVASTDANARVKKIKFFALKPLEDFFTAAPVLAQAAEASGQSTESQAKVSAAERKLQE 512
            ::|:.|||..|.::..|.|::....|       ...|:.:...|               |.:||.
Human   517 QQYVRSRPAPSPESIKRAKEMDLVGL-------GLHPLFSSRFE---------------EEELQR 559

  Fly   513 EKHDILVKMRSFRPGGTVFELNTTQKSTQFIVMKEKRMQHAEVINKFRQ-QRAEEDIDEEKKTIE 576
            .:  ::..::::|...|:||:|.:.:.....||:.||.:..:.|.:|:| |:..::..|     .
Human   560 LR--LVDSIKNYRSRATIFEINASSRDLCSQVMRAKRQKDRKAIARFQQGQQGRQEQQE-----G 617

  Fly   577 ALNPSSGR------MPTADE-----EAISSTFNKVVAPKRLQ---NMDALYKDKPKKKKRKINSK 627
            .:.|:..|      .|..:|     |::...|::||..||.:   |..|      |:::.:...:
Human   618 PVGPAPSRPALQEKQPEKEEEEEAGESVEDIFSEVVGRKRQRSGPNRGA------KRRREEARQR 676

  Fly   628 DEDHYVPYQSADKHTEDGLAINN----FERQAQNAEFSVSDRDLSQEVKHKPGLKKWDRIKKKMV 688
            |::.|:||:..|..:|.||:|:.    ||:||..|...:.. |.:|.:.......||||.||:.|
Human   677 DQEFYIPYRPKDFDSERGLSISGEGGAFEQQAAGAVLDLMG-DEAQNLTRGRQQLKWDRKKKRFV 740

  Fly   689 --SVQDPRANKIRTESGAWIPASFKTGRYAEWKEKSKIEDQLQRENAGSDDEN------------ 739
              |.|:.: .||:||||.:|.:|:|...|.:||:|.||:|:...|...||...
Human   741 GQSGQEDK-KKIKTESGRYISSSYKRDLYQKWKQKQKIDDRDSDEEGASDRRGPERRGGKRDRGQ 804

  Fly   740 ---AKPLSHAQRYPVSRHARHNLKLELKKRLTGNDKEMRRPEQIVKSRMR---LEFIKK------ 792
               ::|  ||...|..|     ::.|||.:           :||:|.|.|   |.|:::
Human   805 AGASRP--HAPGTPAGR-----VRPELKTK-----------QQILKQRRRAQKLHFLQRGGLKQL 851

  Fly   793 --RNEENAE--------RKSENRKRSMRK 811
              ||....:        |.:.::|..|||
Human   852 SARNRRRVQELQQGAFGRGARSKKGKMRK 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32344	NP_612028.4	DEADc	41..243	CDD:238167	144/201 (72%)
		DEXDc	54..243	CDD:214692	136/188 (72%)
		HELICc	263..384	CDD:238034	70/120 (58%)
		DBP10CT	666..721	CDD:285373	23/56 (41%)
DDX54	NP_001104792.1	PRK01297	1..469	CDD:234938	249/406 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78		6/15 (40%)
		Q motif	96..124		20/27 (74%)
		DEADc	98..300	CDD:238167	144/201 (72%)
		DEAD box	247..250		2/2 (100%)
		HELICc	315..441	CDD:238034	72/125 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..698		26/112 (23%)
		Interaction with nuclear receptors	605..647		8/46 (17%)
		DBP10CT	714..774	CDD:285373	23/61 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143880
Domainoid	1	1.000	241	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E2759_KOG0337
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5590
Inparanoid	1	1.050	589	1.000	Inparanoid score	I997
Isobase	1	0.950	-	0	Normalized mean entropy	S1304
OMA	1	1.010	-	-		QHG52023
OrthoDB	1	1.010	-	-		D255924at33208
OrthoFinder	1	1.000	-	-		FOG0004971
OrthoInspector	1	1.000	-	-		oto90793
orthoMCL	1	0.900	-	-		OOG6_101760
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720