DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32344 and Ddx54

DIOPT Version :9

Sequence 1:	NP_612028.4	Gene:	CG32344 / 326208	FlyBaseID:	FBgn0052344	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_082317.1	Gene:	Ddx54 / 71990	MGIID:	1919240	Length:	874	Species:	Mus musculus

Alignment Length:	867	Identity:	362/867 - (41%)
Similarity:	513/867 - (59%)	Gaps:	122/867 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IPGFPSLDNDAGTSDRGADILKSKS-KKNKSGGFQSMGLGFELIKGITKRGYKVPTPIQRKTIPL 72
            :|.||:.:..:.......::::::: ||.||||||||||.:.:.|||.|:||||||||||||||:
Mouse    64 LPSFPTSECVSDVEPDTREMVRAQNKKKKKSGGFQSMGLSYPVFKGIMKKGYKVPTPIQRKTIPV 128

  Fly    73 ILEGRDVVAMAKTGSGKTACFLIPLFEKLQRREPTKGARALILSPTRELAVQTYKFIKELGRFME 137
            ||:|:||||||:||||||||||:|:||:|:.|....||||||||||||||:||.||.||||:|..
Mouse   129 ILDGKDVVAMARTGSGKTACFLLPMFERLKARSAQTGARALILSPTRELALQTMKFTKELGKFTG 193

  Fly   138 LKSILVLGGDSMDSQFSAIHTCPDVIVATPGRFLHLCVEMDLKLNSIEYVVFDEADRLFEMGFGE 202
            ||:.|:||||.|:.||:|:|..||:|:|||||.:|:.|||:|||.|:||||||||||||||||.|
Mouse   194 LKTALILGGDKMEDQFAALHENPDIIIATPGRLVHVAVEMNLKLQSVEYVVFDEADRLFEMGFAE 258

  Fly   203 QLNETLHRLPSSRQTVMFSATLPKLLVEFARAGLNDPVLIRLDVESKLPDALALKFLYCRPDDRY 267
            ||.|.:.|||...|||:|||||||||||||||||.:||||||||:|||.:.|...||..|.|.:.
Mouse   259 QLQEIIGRLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIRLDVDSKLNEQLKTSFLLVREDTKA 323

  Fly   268 TALVVLLKYVIPVQSQTVVFAGTQHHVELISYILTEAGISNASVYSSLDPAARKINTAKFVNKKV 332
            ..|:.||:.|:..|.|||||..|:||.|.::.:|...|:|.|.:||:||..|||||.|||.:.|.
Mouse   324 AVLLYLLQNVVRPQDQTVVFVATKHHAEYLTELLMGQGVSCAHIYSALDQTARKINLAKFTHNKC 388

  Fly   333 SVLIVTDVAARGIDIPSLDFVVNLHFPGKPKLFVHRVGRCARAGRTGTAYSIVSTDDTAHLLDLH 397
            |.|||||:||||:|||.||.|:|..||.|.|||:|||||.|||||:|||||:|:.|:..:|||||
Mouse   389 STLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSLVAPDEVPYLLDLH 453

  Fly   398 LFLNRPF---------NIHDS----SALGTIPQDLLEEEHLTV-TDIKKSHHIAGVLRTSENAYK 448
            |||.|..         ::.|:    ..||.:||.::::|..:: |.:..|..:.|:.|.:.||.:
Mouse   454 LFLGRSVTLARPCEEPSVADAVGRDGVLGRVPQSVVDDEDSSLQTAMGASLDLQGLHRVANNAQQ 518

  Fly   449 KYLSSRPVASTDANARVKKIKFFALKPLEDFFTAAPVLAQAAEASGQSTESQAKVSAAERKLQEE 513
            :|:.|||..|.::..|.|::....|       ...|:.:...|               |.:||..
Mouse   519 QYVRSRPAPSPESIKRAKELDLAEL-------GLHPLFSSCFE---------------EGELQRL 561

  Fly   514 KHDILVKMRSFRPGGTVFELNTTQKSTQFIVMKEKRMQHAEVINKFRQQRAEEDIDEEKKTIEAL 578
            :  ::..::::|...|:||:|.:.|.....:|:.||.:..:.:..|:|:|      :|::...|
Mouse   562 R--LVDSIKNYRTRTTIFEINASSKDPSSQMMRAKRQRDRKAVASFQQRR------QERQEGPA- 617

  Fly   579 NPSSGR-MPTADE----EAISSTFNKVVAPKRLQNMDALYKDKP------KKKKRKINSKDEDHY 632
            :|:..| :|..:|    |.:...|.:||..||         .:|      |:::.:...:|::.|
Mouse   618 DPAPQRELPQEEEEEMVETVEGVFTEVVGQKR---------PRPGPSQGAKRRRMETRQRDQEFY 673

  Fly   633 VPYQSADKHTEDGLAINN----FERQAQNAEFSVSDRDLSQEVKHKPGLKKWDRIKKKMV--SVQ 691
            |||:..|..:|.||:::.    ||:|...|...:.. |.:|.:.......||||.||:.|  |.|
Mouse   674 VPYRPKDFDSERGLSVSGAGGAFEQQVAGAVLDLMG-DEAQNMSRGQQQLKWDRKKKRFVGQSGQ 737

  Fly   692 DPRANKIRTESGAWIPASFKTGRYAEWKEKSKIEDQLQRENAGSDDENAKPLSHAQR-------- 748
            :.: .||:||||.:|.:|:|...|.:||:|.||:|:...|...|:.....|....:|
Mouse   738 EDK-KKIKTESGRFISSSYKRDLYQKWKQKQKIDDRDSEEEGPSNQRGPGPRRGGKRGRSQGTSQ 801

  Fly   749 -----YPVSRHARHNLKLELKKRLTGNDKEMRRPEQIVKSRMR-----------LEFIKKRNEEN 797
                 .|..|     ::.|||.:           |||:|.|.:           |:.:..||...
Mouse   802 PRASSVPAGR-----MRSELKTK-----------EQILKQRRQAQKQRFLQRGGLKQLSARNRRR 850

  Fly   798 AE--------RKSENRKRSMRK 811
            |:        |.:.:||..|||
Mouse   851 AQELRQGAFGRGAPSRKGKMRK 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32344	NP_612028.4	DEADc	41..243	CDD:238167	145/201 (72%)
		DEXDc	54..243	CDD:214692	137/188 (73%)
		HELICc	263..384	CDD:238034	69/120 (58%)
		DBP10CT	666..721	CDD:285373	23/56 (41%)
Ddx54	NP_082317.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76		3/11 (27%)
		SrmB	69..537	CDD:223587	262/467 (56%)
		Q motif	95..123		20/27 (74%)
		DEADc	97..299	CDD:238167	145/201 (72%)
		DEAD box	246..249		2/2 (100%)
		HELICc	314..440	CDD:238034	72/125 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..687		28/121 (23%)
		DBP10CT	706..766	CDD:285373	23/61 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..874		50/178 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834116
Domainoid	1	1.000	243	1.000	Domainoid score	I2212
eggNOG	1	0.900	-	-		E2759_KOG0337
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5590
Inparanoid	1	1.050	595	1.000	Inparanoid score	I960
Isobase	1	0.950	-	0	Normalized mean entropy	S1304
OMA	1	1.010	-	-		QHG52023
OrthoDB	1	1.010	-	-		D268859at2759
OrthoFinder	1	1.000	-	-		FOG0004971
OrthoInspector	1	1.000	-	-		oto94376
orthoMCL	1	0.900	-	-		OOG6_101760
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R289
SonicParanoid	1	1.000	-	-		X3504
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750