Protein Alignment Claspin and CLSPN

DIOPT Version :10

• Sequence 1: NP_728981.1
• Gene: Claspin / 326205
• FlyBaseID: FBgn0052251
• Length: 1465
• Species: Drosophila melanogaster
• Sequence 2: NP_071394.2
• Gene: CLSPN / 63967
• HGNCID: 19715
• Length: 1339
• Species: Homo sapiens
• Alignment Length: 1435
• Identity: 324/1435 - (22%)
• Similarity: 571/1435 - (39%)
• Gaps: 377/1435 - (26%)

  Fly   221 SKKLAKKQKQQEDDKEDNGTEQEKKKPSPKSKAKKSDKSKIDSL-MDNEED--AGEDLKMYQEDQ 282
            ||||..::..|:.|.|   ||.....|         :|:..||. .:|:|:  ||::.|:
Human    53 SKKLKNRKVLQDSDSE---TEDTNASP---------EKTTYDSAEEENKENLYAGKNTKI----- 100

  Fly   283 EPQKQKTKKSAKKTNKDSKEESGEDQEHQE----QKKPLKKIKLDN-------IDTKEDKEQIVK 336
                    |...||..||.|...|...:||    |.||..::.|.:       .|.|..|:.|..
Human   101 --------KRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHD 157

  Fly   337 PKKMAKKNKQKVLSDDESEENQNEKVDQDHDLKKMSSENELEMGSDKEDQEMQEPPKKA---KKN 398
            .:..|.|.|.|.....|.||.:.||:.|   |||..::|        ::.::::|...:   ..:
Human   158 KEGTAGKAKVKSKRRLEKEERKMEKIRQ---LKKKETKN--------QEDDVEQPFNDSGCLLVD 211

  Fly   399 KQRMDSESEDEIPKTESEKITSSPKNKLKGLVDSESEPEETAEEV-SPVKNKLKGLVDSESEPEL 462
            |...::..|||         .:||           .|.||:.|.: :.||||:|  ...:.||.|
Human   212 KDLFETGLEDE---------NNSP-----------LEDEESLESIRAAVKNKVK--KHKKKEPSL 254

  Fly   463 DNPEESAGEQEAPMESALSREKPKKAKVVRESAKKALEGMQAIQSEQQRLHREAHINVPYHQPKP 527
            ::...|. |:.:.:....:|::.|.|::.:|:.|:       :.||.|||.||:.:|:|||.|:.
Human   255 ESGVHSF-EEGSELSKGTTRKERKAARLSKEALKQ-------LHSETQRLIRESALNLPYHMPEN 311

  Fly   528 RTLKEFLSRRTINAPLATALAGGSPMPSRQPRKSVGLRMTREELEAYAKLMEDRAKEATEFFKSE 592
            :|:.:|..|:              |.|:........|:.::.: .::.|.:.|.|.      .:|
Human   312 KTIHDFFKRK--------------PRPTCHGNAMALLKSSKYQ-SSHHKEIIDTAN------TTE 355

  Fly   593 SESDEEDDSENEEPMELKDNPGVMDEMLDNPKTPEQPKNDTEDMTSQAVIEVPVLGEDKTDDTVG 657
            ..||.                        :.|..||......::.:.|   :||:.::....|..
Human   356 MNSDH------------------------HSKGSEQTTGAENEVETNA---LPVVSKETQIITGS 393

  Fly   658 DEAMVADSITEEE-PIASTSTAAALKLA--DNFEIQQETN--AKSPSKVCLV------------- 704
            ||:...|.:..|| .|......:.::.:  |:..:|||:|  ..:.|:.|.|
Human   394 DESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEG 458

  Fly   705 ---------TEVVELPKLDLSTINITPSSKPATPKISEVIRQLKIEKSLDESPSLKGDPNMVIDL 760
                     .|.||.|:....:..:.|..|.....:.. ::||.::.|:  .|.|..|.:..:.|
Human   459 EGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDR-LKQLGVDVSI--KPRLGADEDSFVIL 520

  Fly   761 ETGDMFAKKPTGVDDLLNRLMK-TREAKKHKTTETVNI------LTTEHGKLEMSK--VSIHLHE 816
            |     .:....::.|..|..| ...|.|.:..:|||:      :.|: ||.|:..  |.:.|..
Human   521 E-----PETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTD-GKEELKADVVPVTLAP 579

  Fly   817 EEI--AKEPKPGAGYMKMQEHLKTLITKKRMEDLRKKQA--------------EEQEKMAEDEEE 865
            :::  |...|||.....::..|:..:..:|.|:.:|:||              ||:|:|.::.||
Human   580 KKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEE 644

  Fly   866 GMDVDEEYEPEDKPGYAEVTINEDEEIIDKVDSTAEDDGDAE-----------ENKNDADEDPED 919
              |.:|:.|.|:|    |..:.|:||    .:...|::|:.|           |.|::.:.|.|:
Human   645 --DGEEKVEKEEK----EEELEEEEE----KEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKEN 699

  Fly   920 N---------------PVEDSEDE-----KNDSESEQECEANPEPETQTRKKNRIIKAFEDD--- 961
            |               |...|.|.     |:.|..........:.||......:..|..|||
Human   700 NDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCS 764

  Fly   962 -----NSDEDDLDLL------------QTPKPSNVAPITATQLQLSAHKLFDVETRRTASDEENE 1009
                 :|.....:|:            ||.:.::..| ||...:..:..||......:||....:
Human   765 LLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFFP-TAGGFRSPSPGLFRASLVSSASKSSGK 828

  Fly  1010 L----------------------LDLCSGQF-------PQTQMLSSDA-------PSVDTAVISQ 1038
            |                      |.|.:|.|       .|:|:|.:|.       .:...|:..:
Human   829 LSEPSLPIEDSQDLYNASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQALKPR 893

  Fly  1039 IPMTQFGGSSQAA--DELEGLCSGTFATQLPSQAPTQQPEQQEESEVPAAVANRIVSSDEEAQED 1101
            :|:.....::..|  |||..||:|.|.:|.....|.:..:::...|:....:.:..|.|
Human   894 LPLASMDENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQD------ 952

  Fly  1102 ALEVDKPRNKKLTKKRPKKKAKLG-------------FSDDEDSDDEVEEF--------DEESDA 1145
               ...|.:.:|.|:  :|::.:|             |..|::.:||.|||        |.|.|:
Human   953 ---ASTPASSELNKQ--EKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDS 1012

  Fly  1146 EPVEEIPE----TFVDY-DSEENEIVVEMTKKDRKIRAANFVDKEAELSESEWGSADE-DEKNMD 1204
            :..|....    ...|: |.:|.|::....|..|::|...:::.|||:|.|:.||.|| |.:.:|
Human  1013 DEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEID 1077

  Fly  1205 EYDIELGDEDQFDRDKLRHELGQIHARKMMDQDIREVRKIKELLFEE---EEEGANRQRQFRWKN 1266
            ||:.::.||.....::|:.::.:||.:.|:|.|.|::|..:|....:   ..:|..|.|:|||||
Human  1078 EYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKN 1142

  Fly  1267 VEAGFSLDDNRTDNGEGNDGSGDEENEHLWRKIRYEREQLLLEKGLKPEVASPLSTSVINTSNNG 1331
            ::....:|....|:.:.......:|:|..|||.|.||||.|.:...:.::.:.....:...|
Human  1143 IDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDS--- 1204

  Fly  1332 NSPAIRRLNIISSKKTTVEVKKNSPFLISKTIAGKQQKSAVR----------------GSFLIRD 1380
                  :..|::.|.|...::||:    |:.:..::.||.:|                ||.|.:.
Human  1205 ------QFMILAKKVTAKALQKNA----SRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQP 1259

  Fly  1381 QQTLSKLAGLTKGTSGDVDAAEGTISVKSAKAKNFVFATLTEEEHENRKRKAADILNSSTETGVN 1445
            :..|.|||.|:.....           ....::||||.||:..:.|..|..:.   :...:.|.:
Human  1260 KAVLQKLAALSDHNPS-----------APRNSRNFVFHTLSPVKAEAAKESSK---SQVKKRGPS 1310

  Fly  1446 FIKKP 1450
            |:..|
Human  1311 FMTSP 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Claspin	NP_728981.1	2A1904	<96..411	CDD:273344	54/206 (26%)
		DNA_pol_phi	<850..933	CDD:461488	30/127 (24%)
CLSPN	NP_071394.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..96		16/54 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..204		20/78 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..285		10/44 (23%)
		PCNA-interacting protein (PIP). /evidence=ECO:0000269|PubMed:27401717	311..318		1/6 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..490		33/187 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	618..707		24/98 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	730..774		8/43 (19%)
		CKB motif 1	910..919		5/8 (63%)
		CKB motif 2	939..948		1/8 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	946..973		7/37 (19%)
		CKB motif 3	976..985		0/8 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	985..1075		28/89 (31%)
		Acidic patch. /evidence=ECO:0000269|PubMed:27401717	988..1086		30/97 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1294..1327		5/25 (20%)