Protein Alignment Claspin and mrc1

DIOPT Version :9

• Sequence 1: NP_001286934.1
• Gene: Claspin / 326205
• FlyBaseID: FBgn0052251
• Length: 1465
• Species: Drosophila melanogaster
• Sequence 2: NP_594486.1
• Gene: mrc1 / 2543240
• PomBaseID: SPAC694.06c
• Length: 1019
• Species: Schizosaccharomyces pombe
• Alignment Length: 1143
• Identity: 243/1143 - (21%)
• Similarity: 426/1143 - (37%)
• Gaps: 271/1143 - (23%)

  Fly   437 EETAEEVSPVKNKLKGLVDSESEPELDNPEESAGEQEAPMESALSREKPKKAKVVRESAKKALEG 501
            :|.|:|:..:.:..:..::.:.|..||.|.....:..|.::..||.....:|.:.:||....||.
pombe     5 DENADELHRMDSSDEASINDDQEDILDTPRTRVRKMLASVDMQLSSNAVSEASLDKESTVGNLEN 69

  Fly   502 MQ-AIQSEQQRLHREAHINVPYHQPKPRTLKEFLSRRTINAPLATALAGGSPMPSRQPRKSVGLR 565
            .: ...|.:..||.:.:....:.....|.      ||.:|.      .||.   |...:|.|
pombe    70 QKNRSYSSEIYLHSDTNFLSNFDSAYERV------RRLLNQ------QGGK---SSLQKKEV--- 116

  Fly   566 MTREELEAYAKLMEDRAKEATEFFKSESESDEEDDSEN---EEPMELKDN--PGVMDEMLDNPKT 625
               |::|         .:|..:..|....|:.:|...|   ::.:|.|.|  ....::::.|..|
pombe   117 ---EQIE---------TQEGGDNAKGSPSSENKDSDRNSRLQQLIEKKRNALKKEQEDLIQNSAT 169

  Fly   626 PEQPKNDTEDMTSQAVIEVPVLGEDKTDDTVGDEAMVADSITEEEPIASTSTAAALKLADNFEIQ 690
             ...|:|..|            .|...|..:.||:.::...|.:..|.:.|..|.|:|..|
pombe   170 -SHSKSDNLD------------SESADDSDLADESELSKKYTSDRKIRNASKKALLELHRN---- 217

  Fly   691 QETNAKSPSKVCLVTEVVELPKLDL----------------------STINIT--PSSKPATPK- 730
               .|:...:..|..|||...|:.|                      ...|.|  |:.:...||
pombe   218 ---TARLTRETALKPEVVVKKKVTLREFFQKIGFKNDNQLENKAISEEEANSTEPPNVEKEEPKP 279

  Fly   731 ---------ISEVIRQLKIEKSLDESPSLKGDPNMVIDLETGDMF-------AKKPTGVDDLLNR 779
                     .||.|::|.:|   |:|..||......:|:....:|       .||    :|....
pombe   280 SVDRSTGIVNSEDIKELSVE---DDSLELKEITPEALDIGQTSLFTTLNQTQVKK----EDNKKF 337

  Fly   780 LMKTREAK--------------KHKTTETVNILTT------EH---GKLEMSKVSIHLHEEEIAK 821
            |:|...||              |.|||...||..:      ||   |||:      .|.|.:::|
pombe   338 LLKEINAKLNEDDIDSELEIEVKPKTTALDNIEKSKLSEENEHGIKGKLK------QLAEIKLSK 396

  Fly   822 EPKPGAGYMKMQEHLKTLITKKR-MEDLRKKQAEEQEKMAEDEEEGM---DVDEEYEPEDKPGYA 882
            :.||......::...:.|:.:.. |..|::.|.||:.|     .:|:   .:..|.|.|:.|  .
pombe   397 DGKPFENEFNIKSFNRNLVKRAAVMAKLQRNQLEEELK-----AKGIYKPTIQGEKEEEEDP--L 454

  Fly   883 EVTINEDEEI--IDKVDSTAEDDGDAEENKNDADE--DPEDNPVEDSEDEKNDSESEQECEANPE 943
            |...|:.|:|  ::|....|.|:|:.    ||.:|  ...:.|...::.......|:...||...
pombe   455 ERARNDAEKIRQLEKASGNASDEGEL----NDEEEVISSSNTPSTKAKTTNKVIISDVIIEATQA 515

  Fly   944 PETQTRKKNRIIKAFED---DNSDEDDLDLLQTPKPSNVAPITATQLQLSAHKLFDVETRRTASD 1005
            ...:.:|.:|::...||   |:....::.:.::...||...|..:..:||:..:.|.:......|
pombe   516 EPKRRQKNSRVVFDEEDLTGDSHGSSNMKISESDDESNGDMIRDSFDRLSSESIKDSQKTEELHD 580

  Fly  1006 E--ENELLDLCSGQFPQTQMLSSDAPSVDTAVISQIPMTQFGGSSQAADELEGLCSGTFATQLPS 1068
            .  .|:.:|..:..:.|....|:...::..|..|| |..::..||:  |:.    :.|.:|| ||
pombe   581 SFGINDEVDQSTSLYVQNSQPSASQLTIVDATYSQ-PPPRWESSSR--DDK----TNTSSTQ-PS 637

  Fly  1069 QAPTQQPEQQEESEVPA---AVANRIVSSDEEAQEDALEVDKPRNKKLTKKRPKKKAKLGFSDDE 1130
            |..:..|.|. :|.:|.   :|.......|||..|:..|..:.....|::.....| ..|.:|..
pombe   638 QVDSLVPTQL-DSTIPTQIDSVQRNKDQDDEEILEERRESRRDSKTFLSRTMLYNK-DTGKADSA 700

  Fly  1131 DSDDEVEEFDEESDAEPVEEIPETFVDYD-----SEENEIVVEMTKKDRKIRAANFVDKEAELSE 1190
            .:.|.:||...|||.|           |.     |::.     ::..|.::...|.:|.|..:.:
pombe   701 WASDLIEEQAIESDDE-----------YAGIGGLSDDG-----LSDSDAELEVQNMIDDETTIQK 749

  Fly  1191 SEWGS---------ADEDEKNMDEY--DIELG--------------DEDQFDRDKLRHE-LGQIH 1229
            .|..|         .|.|||.:.:.  |:..|              |.|..|...||.| |.::.
pombe   750 GEVASMAQFAKDQEMDRDEKLVKQLMKDVTTGALRKRNRNGFAALDDSDDEDYSNLRREKLKELR 814

  Fly  1230 ARKMMDQ---DIREVRKIKELLFEEEEEGANRQRQFRWKNVEAGFSLDDNRTDNGEGNDGSGDEE 1291
            .:|:::.   ::.|..|.|..|...|:...:.:....|        ||....|:|.|:...||
pombe   815 RQKLLEDGNLNVLEGDKRKAFLATVEDSLVSSKDNLTW--------LDATVEDSGVGSSDLGD-- 869

  Fly  1292 NEHLW--RKIRYEREQLLLEKGLK------PEVASPL---STSVINTSNNGNS--------PAIR 1337
             |:|:  :.:.:|.|:.:.|:..:      |.|...:   .:|..:||:| ||        |.:|
pombe   870 -EYLYSEQSLNHEEEEQMEEELSEIFSSGGPNVVDRVYLKKSSTRHTSDN-NSLEEVLPIFPGVR 932

  Fly  1338 RLNIISSKKTTVEVKKNSPFLISKTIAGKQQKSAVRGSFLIRDQQTLSKLAGL-TKGTSGDVDAA 1401
            :|  :|:.::    :|........::..|..|:.:..|   ..:....|..|| .:.:..|:...
pombe   933 KL--VSNSQS----EKIGDLSNDNSMGAKSYKTPIISS---TQRPQGRKFRGLMNQSSKADISRT 988

  Fly  1402 EGTISVKSAKAKNFVFATLTEEEHENRKRKAADILNSS 1439
            ....|:|          .:...:..|..|..|.:.|.|
pombe   989 VDAGSIK----------VVPNSQSANPPRLLASLNNYS 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Claspin	NP_001286934.1	infB	58..>180	CDD:177089
		2A1904	<96..411	CDD:273344
		MDN1	<861..947	CDD:227596	20/92 (22%)
mrc1	NP_594486.1	MRC1	701..837	CDD:286523	32/151 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14396
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100