DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Claspin and clsp-1

DIOPT Version :9

Sequence 1:	NP_001286934.1	Gene:	Claspin / 326205	FlyBaseID:	FBgn0052251	Length:	1465	Species:	Drosophila melanogaster
Sequence 2:	NP_001251008.1	Gene:	clsp-1 / 172742	WormBaseID:	WBGene00009127	Length:	752	Species:	Caenorhabditis elegans

Alignment Length:	898	Identity:	195/898 - (21%)
Similarity:	348/898 - (38%)	Gaps:	285/898 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   653 DDTVGDEAMVAD---SITEEEPIASTSTAAALKLADNFEIQQETNAKSPSKVCLVTEVVELPKLD 714
            |||....::||:   |.::|:.|:|.:|....:..::.::::....|:     |..|...||
Worm    14 DDTDSPSSLVAEHTMSDSQEQLISSENTEVDKQAEEDRKLRRLNRRKA-----LALERSPLP--- 70

  Fly   715 LSTINITPSSKPATPKISEVIRQLKIEKSLDESPSLKGDPNMVIDLETGDMFAKKPTGVDDLLNR 779
                         .||:..|:.                ..|..|||...|         ||..|:
Worm    71 -------------VPKLGRVLL----------------SANSTIDLTNED---------DDPSNK 97

  Fly   780 -LMKTREAKKHKTTETVNILTTEHGKLEMSKVSIHLHEEEIAKEPKPGAGYMKMQEHL-KTLIT- 841
             ..||..|:|                  :.|::....|.::...|:      |:.::. |:|:|
Worm    98 WFKKTFNAEK------------------IPKLAKSPEEAKLFAVPR------KISKNAPKSLLTS 138

  Fly   842 ---KKR----MEDLRKKQAEEQEKMAEDEEE----GMDVDEEYEPEDKPGYAEVTINEDEEIIDK 895
               ||:    |...|:|:.|::.||.|::.|    |.|.:||.:...|....:..:||:|
Worm   139 ETLKKKLQASMSAKRRKEQEQRRKMYEEDNEHLKAGSDEEEEEDVVFKKKKGKKPVNEEE----- 198

  Fly   896 VDSTAEDDGDAEENKNDADEDPEDNPVEDSEDEKNDSESEQECEANPEPETQTRKKNRIIK---- 956
                       .::::|.|.:||::..||| ||||:..::.|...|...::.|......:|
Worm   199 -----------YKSEDDEDYEPENSGEEDS-DEKNNGRADDEMSVNLLNDSFTYDVFNNVKRSGP 251

  Fly   957 ----AFEDDNSDEDDLD---LLQTPKPSNVAPITATQLQLSAHKLFDVETRRTASDEENELLDLC 1014
                :..|..|:.|.::   ::|.|        |.|::                :...|::|:||
Worm   252 GSTVSNFDSRSEADVVEKNGVVQLP--------TMTEI----------------TGGSNDILNLC 292

  Fly  1015 SGQ--------FPQTQMLSSDAPSVDTAVISQIPMTQFGGSSQAADELEGLCSGTFATQLPSQAP 1071
            .|.        ||.|..:..:..:.:..:  .:|..                    :|.:.|..|
Worm   293 PGSFGVSQSAGFPDTLQMLIEEDTTERKI--NLPQN--------------------STSVSSDKP 335

  Fly  1072 -TQQPEQQEESEV------PAAVANRIVSSDEEAQEDALEVDKPRN--------------KKLTK 1115
             .::.|.::|.:|      ||...:|::.||||  :|.:|...|..              |::.:
Worm   336 RLEESESEDEDDVGVKRRLPAVKNHRVLDSDEE--DDVIEETLPSQDVFGSGTLEDSETIKEICE 398

  Fly  1116 KRPKKKAKLG-------------FSDDEDSDDEVEEFDEESD--AEPVEEIPETFVD-------- 1157
            |..:...|:.             .||.||||:|.||.:||.|  .||.|:..|:..|
Worm   399 KSGEFTEKIETVLEEKTELKRVVLSDGEDSDEEAEEAEEEGDDEEEPEEDDIESENDEAETEGVE 463

  Fly  1158 -----YDSEENEIVV----EMTKKDRKIRAANFVDKEAELSESEWGSADEDEKNMDE-YDIELGD 1212
                 :|.|::|:.:    :..:..:||:.....|.||.||..:.||..|||:.|:. |:.|.||
Worm   464 APDPNFDDEDDELAILKRLQHQEYKQKIKKRTLFDDEASLSGDDVGSDLEDEEGMENVYEAEEGD 528

  Fly  1213 EDQF-DRDKLRHELGQIHARKMMDQDIREVRKIKE-LLFEEEEEGANRQRQFRWK-----NVEAG 1270
            .|.. |.|.:|.:..::..::..|::.||:.|::: ||.:.:..|....||||:|     .::.|
Worm   529 ADDVPDNDTIRRQNHKLLLKQENDKEQRELAKLQDRLLADGDLGGVETNRQFRFKLREEVQIQMG 593

  Fly  1271 FSLDDNRTDNGEGNDGSGD----EENEHLWR------KIRYER-EQLLLEKGLKPEVASPLSTSV 1324
                    |:.:||||.|:    ||:|...:      |.:||. |:|:|
Worm   594 --------DDVDGNDGDGEDDEPEEDEQKKKERAEMIKFKYEHAEELML---------------- 634

  Fly  1325 INTSNNGNSPAIRRLNII-SSKKTTVEVKK--------NSPFLISKTIAGKQQKSAVRGSFLIRD 1380
            ::....|:....|...:. .::||.:|..:        :.|.|:|||......:..:.|......
Worm   635 LDEPKQGDDMFARAGKLFKKTEKTVIEFSEETMFKPRLSKPSLLSKTTLAVTFQEVLNGPGGAAK 699

  Fly  1381 QQTLSKLAGLTKGTSGDVDAAEGTISV---------KSAKAKNFVFATLTEEE 1424
            |..:......|..::|.:.:....:|.         .||.||....:.|:..|
Worm   700 QMYVQSFEKPTPLSTGHISSPSSRLSTGKRLLKSPESSASAKRVRSSKLSSLE 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Claspin	NP_001286934.1	infB	58..>180	CDD:177089
		2A1904	<96..411	CDD:273344
		MDN1	<861..947	CDD:227596	23/89 (26%)
clsp-1	NP_001251008.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162546
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8226
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007571
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14396
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.980