Protein Alignment Claspin and clspn

DIOPT Version :9

• Sequence 1: NP_001286934.1
• Gene: Claspin / 326205
• FlyBaseID: FBgn0052251
• Length: 1465
• Species: Drosophila melanogaster
• Sequence 2: XP_002938885.3
• Gene: clspn / 100124314
• XenbaseID: XB-GENE-992187
• Length: 1289
• Species: Xenopus tropicalis
• Alignment Length: 1614
• Identity: 365/1614 - (22%)
• Similarity: 602/1614 - (37%)
• Gaps: 541/1614 - (33%)

  Fly    29 EEDEQMVSGEDLLGGKSLIMSDDSEAEDGSQEKPLSPKDRRRRMMDSDQEEDAMDQGNGDSIKNS 93
            ||::.::..||.:..|  |:..||::..||.|  ::..|.:.:::|..::.|.
 Frog     6 EEEQLVLEPEDSISLK--ILETDSDSGQGSCE--MASADDQNKILDCIEDRDT------------ 54

  Fly    94 EDVEEEMVSRPKKKVSAIIDSDNDDEQQAEKKTQKEEGKQPVKSKKKRSQVNQEDQEKPVKSNKT 158
             |.||.:|.:..|....:::||:|:|.:..|
 Frog    55 -DEEEFLVCKKSKSKKILVESDSDEEMETSK---------------------------------- 84

  Fly   159 KKAVKNKTQANKAEDDQDNPS-KEDKPKKVVKNKKQTNKDGKPQTNEEYDHHQQHEKPAKTQKSK 222
               :.:..:.|...|:::|.| ..:||:::     |:.......::.|.|              .
 Frog    85 ---IADNVKGNSKNDEENNISAHREKPRRI-----QSALFDSDNSDNEVD--------------V 127

  Fly   223 KLAKKQKQQEDDKEDNGTEQEKKKPSPKSKAKKSDKSKIDSLMDNEEDAGEDLKMYQEDQEPQKQ 287
            :::.:|...|..:.|:|: .||:.|:                                    .|.
 Frog   128 QMSTRQNTIERPESDHGS-LEKESPT------------------------------------VKH 155

  Fly   288 KTKKSAKKTNKDSKEESGEDQEHQEQKKPLKKIKLDNIDTKEDKEQIVKPKKMAKKNKQKVLSDD 352
            ||.||.||....:||               |::|      .:.|.:|.|.:|:.::.:||..:..
 Frog   156 KTSKSLKKQGDTNKE---------------KRVK------NKSKHKIQKEEKVKRRTQQKSKAVK 199

  Fly   353 ESEENQNEKVDQDHDLKKMSSENELEMGSDKEDQEMQEPPKKAKKNKQRMDSESEDEIPKTESEK 417
            |...|.|   |....|.....|||:..|.|..::|
 Frog   200 EDRPNLN---DSGCLLNGDLFENEVGSGVDSNEEE------------------------------ 231

  Fly   418 ITSSPKNKLKGLVDSESEPEETAEEVSPVKNKLKGLVDSESEPELDNPE-ESAGEQEAPMESALS 481
                                   |.:..::.|:||.::|.|..:.:..| |:.|.||       :
 Frog   232 -----------------------ESLDAIRTKIKGKLNSHSTEDYEGFELETEGMQE-------T 266

  Fly   482 REKPKKAKVVRESAKKALEGMQAIQSEQQRLHREAHINVPYHQPKPRTLKEFLSRRTINAPLATA 546
            :||.|:    |::|:...|.|:.:.||.|||.||:.:::|||.|:|:|:.:|..||      ...
 Frog   267 QEKRKE----RKAARLGKEAMKQMHSETQRLMRESSVSLPYHLPEPKTIHDFFRRR------PRP 321

  Fly   547 LAGGSPM---------PSRQPRKSVGLRMTREELEAYAKLMEDRAKEATEFFKSESESDEEDDSE 602
            |..|:.|         |..:.:|:     |:||:.|       ..::.....|.:.|..||::|.
 Frog   322 LCQGNAMHLIKSTKYQPCTEEKKN-----TKEEICA-------EVQKGDYVSKEDLEISEENNSL 374

  Fly   603 NEEPMELKDNPGVMDEMLDNPKTPEQPKNDTEDMTSQAVIEVPVLGEDKTDDTVGDEAMVADSIT 667
            |.:.....       .:||..|...     ||             |..|:.:||     |...|.
 Frog   375 NPQCSHAA-------ALLDVQKDAH-----TE-------------GISKSTETV-----VNGEIN 409

  Fly   668 EEEPIASTSTAAALKLADNFEIQQETNAKSPSKVCLVTEVVELPKL--DLSTI----------NI 720
            |        ....|...|.|......:.:....:..|.|:.:.|.:  ..||:          |:
 Frog   410 E--------NLIQLDKEDTFNHNNNVHKQEAVGLIAVNEIFQSPSILQPESTVCEQIQNNVDSNL 466

  Fly   721 TPSSKPATPKIS--EVIRQLKIEKSLDESPSLKGDPNMVIDLETGDMFAKKPT-GVDDLLNRLMK 782
            .|......||:|  |.:|.|.::.|:  .|.|..:....::|:     ..||. ..:.|..|.:|
 Frog   467 MPEQPLHKPKLSKLEKLRALGVDLSI--KPRLCPNDGSFVNLD-----EPKPNKEFEALKERFLK 524

  Fly   783 TREAKKHKTTE---TVNIL---TTEHGKLEMSK--VSIHLHEEEIAK--EPKPG----AGYMKMQ 833
            ....|.....|   .:||:   ||..||.|:..  |.:.:..|::.:  ..|||    |...|:|
 Frog   525 HSLQKAKPRAERKVNLNIIRKETTADGKEELKAEIVPVVMATEKLDESIHQKPGEKLQALKFKLQ 589

  Fly   834 EHLKTLITKKRMEDLRKKQA---EEQEKMAEDEEEGMDVDEEYEPEDKPGYAEVTINEDEEIIDK 895
            |.:|.    :|:|:.:|:||   .:.|...||:||..::.:|.|.:||.......:.|::|
 Frog   590 EAMKV----RRIEERQKRQALYKLDNEDGFEDDEEEEEMTDESEDDDKNAETADYLGEEDE---- 646

  Fly   896 VDSTAEDDGDAEENKNDADEDPE--------------------DN--PVEDS------------- 925
                 |:.|||.|:::|....||                    ||  .:.||
 Frog   647 -----EEAGDAAEDEDDTGNVPEIVVPVPRPTVTTDSTLMLFKDNSSKIGDSLPDESVCKRTNRL 706

  Fly   926 EDE--------KNDSESEQECEANPEPETQTRKKNRIIKAFEDDNSD------------------ 964
            |||        :|...|..|..::..|..|  ..|:..:...:.|:.
 Frog   707 EDEDSLLPQLKENSHNSSFELISSMIPSYQ--PFNKTARGVTNSNNGGFRSPSPVNFKTSFLSSA 769

  Fly   965 --------------EDDLDLLQT---PKPSNVAPITATQLQLSAH-----KLFDVE--------- 998
                          ||..||...   ||.|.:....::|.|.|..     :|.|.:
 Frog   770 SKSSGKMSEPSLPVEDSQDLYNASPEPKVSYLCAGRSSQFQFSLEDDTQSQLLDADGFLNVGRHQ 834

  Fly   999 ------TRRTASD--EEN-------ELLDLCSGQFPQTQMLSSDAPSVDTAVISQIPMTQFGGSS 1048
                  ..|.|.|  :||       ||||||||||..:...:|.|             |:.....
 Frog   835 SKYSSAKHRLALDTMDENAMDANMDELLDLCSGQFKDSISGTSQA-------------TEKEAKK 886

  Fly  1049 QAADELEGLCSGTFATQLPSQAPTQQP----------EQQEESEVPAAVANRIVSSDEEAQEDAL 1103
            |..|||..||||.|.:|  :...||..          |:::.|:|.|..::..::  |..||:..
 Frog   887 QPMDELLELCSGKFVSQ--ADCSTQDSSASAKDSSANEKKDMSDVAALGSSSFLA--EREQEEGE 947

  Fly  1104 EVDKPRNKKLTKKRPKKKAKLGFSDDEDSDDEVEEFDEESDAEPVEEIPETFVDYDSEENEIVVE 1168
            |.:....|.|.           ...:.|:|:..||.:.|.|.|..|        |:.:|:||:.:
 Frog   948 EEEFGEFKLLP-----------CDSESDNDENNEEEEGEKDNEDNE--------YEEDEDEILQQ 993

  Fly  1169 MTKKDRKIRAANFVDKEAELSESEWGSADEDEKNMDEYDIELGDEDQFDRDKLRHELGQIHARKM 1233
            ..|  ||:|..:|::.|||||.|:.||.||.|.:.|||:.|..|||....::|:.::.:||.:..
 Frog   994 QQK--RKLRLKDFMEDEAELSGSDVGSGDEYEGDDDEYEEEAIDEDLPSDEELQDQVNKIHMKVT 1056

  Fly  1234 MDQDIREVRKIKELLFEE---EEEGANRQRQFRWKNVEAGFSLDDNRTDNGEGNDGSGD----EE 1291
            ||:|.|::|..:|....:   ..:|..|.|:|||||::....||..|.|: |..|..|:    |:
 Frog  1057 MDEDQRQLRLYQERYLADGDLHSDGPGRTRKFRWKNLDDASQLDMFRRDS-EVEDADGENEETED 1120

  Fly  1292 NEHLWRKIRYEREQLLLEKGLKPEVASPLSTSVINTSNN-------GNSPAIRRLNIISSKKTT- 1348
            .|..|||.|:||||.|.::            :.:...||       |......:|    :||.|
 Frog  1121 TELKWRKQRFEREQWLRQQ------------TQVGRDNNEEEEEDIGEDSQFMKL----AKKVTA 1169

  Fly  1349 ------VEVKKNSPFLISKTIAGKQQKSAVR---------GSFLIRDQQTLSKLAGLTKGTSGDV 1398
                  |..:.|.|    |.:..|.|...:|         ||.|.:.::.|.|||.::     |:
 Frog  1170 KALQKKVSTELNEP----KKLEAKNQYEVIRPFSHPKLRTGSLLSKPKEVLQKLAAVS-----DL 1225

  Fly  1399 DAAEGTISVKSAKAKNFVFATLTEEEHENRKRKAADILNSSTETGVNF-IKKPK 1451
            :..      ....::||||.|::    ..:|.:..|...|.....::. :..||
 Frog  1226 NPN------APRNSRNFVFQTVS----PGKKEEPTDKPRSKVRKNISVAVPSPK 1269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Claspin	NP_001286934.1	infB	58..>180	CDD:177089	19/122 (16%)
		2A1904	<96..411	CDD:273344	53/315 (17%)
		MDN1	<861..947	CDD:227596	29/128 (23%)
clspn	XP_002938885.3	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2716
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3546
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007571
OrthoInspector	1	1.000	-	-		oto105485
Panther	1	1.100	-	-	LDO	PTHR14396
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7601
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.150