Protein Alignment Claspin and clspn

DIOPT Version :10

• Sequence 1: NP_728981.1
• Gene: Claspin / 326205
• FlyBaseID: FBgn0052251
• Length: 1465
• Species: Drosophila melanogaster
• Sequence 2: XP_002938885.3
• Gene: clspn / 100124314
• XenbaseID: XB-GENE-992187
• Length: 1289
• Species: Xenopus tropicalis
• Alignment Length: 1616
• Identity: 364/1616 - (22%)
• Similarity: 603/1616 - (37%)
• Gaps: 545/1616 - (33%)

  Fly    29 EEDEQMVSGEDLLGGKSLIMSDDSEAEDGSQEKPLSPKDRRRRMMDSDQEEDAMDQGNGDSIKNS 93
            ||::.::..||.:..|  |:..||::..||.|  ::..|.:.:::|..::.|.
 Frog     6 EEEQLVLEPEDSISLK--ILETDSDSGQGSCE--MASADDQNKILDCIEDRDT------------ 54

  Fly    94 EDVEEEMVSRPKKKVSAIIDSDNDDEQQAEKKTQKEEGKQPVKSKKKRSQVNQEDQEKPVKSNKT 158
             |.||.:|.:..|....:::||:|:|.:..|
 Frog    55 -DEEEFLVCKKSKSKKILVESDSDEEMETSK---------------------------------- 84

  Fly   159 KKAVKNKTQANKAEDDQDNPS-KEDKPKKVVKNKKQTNKDGKPQTNEEYDHHQQHEKPAKTQKSK 222
               :.:..:.|...|:::|.| ..:||:::     |:.......::.|.|              .
 Frog    85 ---IADNVKGNSKNDEENNISAHREKPRRI-----QSALFDSDNSDNEVD--------------V 127

  Fly   223 KLAKKQKQQEDDKEDNGTEQEKKKPSPKSKAKKSDKSKIDSLMDNEEDAGEDLKMYQEDQEPQKQ 287
            :::.:|...|..:.|:|: .||:.|:                                    .|.
 Frog   128 QMSTRQNTIERPESDHGS-LEKESPT------------------------------------VKH 155

  Fly   288 KTKKSAKKTNKDSKEESGEDQEHQEQKKPLKKIKLDNIDTKEDKEQIVKPKKMAKKNKQKVLSDD 352
            ||.||.||....:||               |::|      .:.|.:|.|.:|:.::.:||..:..
 Frog   156 KTSKSLKKQGDTNKE---------------KRVK------NKSKHKIQKEEKVKRRTQQKSKAVK 199

  Fly   353 ESEENQNEKVDQDHDLKKMSSENELEMGSDKEDQEMQEPPKKAKKNKQRMDSESEDEIPKTESEK 417
            |...|.|   |....|.....|||:..|.|..::|
 Frog   200 EDRPNLN---DSGCLLNGDLFENEVGSGVDSNEEE------------------------------ 231

  Fly   418 ITSSPKNKLKGLVDSESEPEETAEEVSPVKNKLKGLVDSESEPELDNPE-ESAGEQEAPMESALS 481
                                   |.:..::.|:||.::|.|..:.:..| |:.|.||       :
 Frog   232 -----------------------ESLDAIRTKIKGKLNSHSTEDYEGFELETEGMQE-------T 266

  Fly   482 REKPKKAKVVRESAKKALEGMQAIQSEQQRLHREAHINVPYHQPKPRTLKEFLSRRTINAPLATA 546
            :||.|:    |::|:...|.|:.:.||.|||.||:.:::|||.|:|:|:.:|..||      ...
 Frog   267 QEKRKE----RKAARLGKEAMKQMHSETQRLMRESSVSLPYHLPEPKTIHDFFRRR------PRP 321

  Fly   547 LAGGSPM---------PSRQPRKSVGLRMTREELEAYAKLMEDRAKEATEFFKSESESDEEDDSE 602
            |..|:.|         |..:.:|:     |:||:.|       ..::.....|.:.|..||::|.
 Frog   322 LCQGNAMHLIKSTKYQPCTEEKKN-----TKEEICA-------EVQKGDYVSKEDLEISEENNSL 374

  Fly   603 NEEPMELKDNPGVMDEMLDNPKTPEQPKNDTEDMTSQAVIEVPVLGEDKTDDTVGDEAMVADSIT 667
            |.:.....       .:||..|...     ||             |..|:.:||     |...|.
 Frog   375 NPQCSHAA-------ALLDVQKDAH-----TE-------------GISKSTETV-----VNGEIN 409

  Fly   668 EEEPIASTSTAAALKLADNFEIQQETNAKSPSKVCLVTEVVELPKL--DLSTI----------NI 720
            |        ....|...|.|......:.:....:..|.|:.:.|.:  ..||:          |:
 Frog   410 E--------NLIQLDKEDTFNHNNNVHKQEAVGLIAVNEIFQSPSILQPESTVCEQIQNNVDSNL 466

  Fly   721 TPSSKPATPKIS--EVIRQLKIEKSLDESPSLKGDPNMVIDLETGDMFAKKPTGVDDLL------ 777
            .|......||:|  |.:|.|.::.|:  .|.|..:....::|:     ..||....:.|
 Frog   467 MPEQPLHKPKLSKLEKLRALGVDLSI--KPRLCPNDGSFVNLD-----EPKPNKEFEALKERFLK 524

  Fly   778 NRLMKTREAKKHKTTETVNIL---TTEHGKLEMSK--VSIHLHEEEIAK--EPKPG----AGYMK 831
            :.|.|.:...:.|.  .:||:   ||..||.|:..  |.:.:..|::.:  ..|||    |...|
 Frog   525 HSLQKAKPRAERKV--NLNIIRKETTADGKEELKAEIVPVVMATEKLDESIHQKPGEKLQALKFK 587

  Fly   832 MQEHLKTLITKKRMEDLRKKQA---EEQEKMAEDEEEGMDVDEEYEPEDKPGYAEVTINEDEEII 893
            :||.:|.    :|:|:.:|:||   .:.|...||:||..::.:|.|.:||.......:.|::|
 Frog   588 LQEAMKV----RRIEERQKRQALYKLDNEDGFEDDEEEEEMTDESEDDDKNAETADYLGEEDE-- 646

  Fly   894 DKVDSTAEDDGDAEENKNDADEDPE--------------------DN--PVEDS----------- 925
                   |:.|||.|:::|....||                    ||  .:.||
 Frog   647 -------EEAGDAAEDEDDTGNVPEIVVPVPRPTVTTDSTLMLFKDNSSKIGDSLPDESVCKRTN 704

  Fly   926 --EDE--------KNDSESEQECEANPEPETQTRKKNRIIKAFEDDNSD---------------- 964
              |||        :|...|..|..::..|..|  ..|:..:...:.|:.
 Frog   705 RLEDEDSLLPQLKENSHNSSFELISSMIPSYQ--PFNKTARGVTNSNNGGFRSPSPVNFKTSFLS 767

  Fly   965 ----------------EDDLDLLQT---PKPSNVAPITATQLQLSAH-----KLFDVE------- 998
                            ||..||...   ||.|.:....::|.|.|..     :|.|.:
 Frog   768 SASKSSGKMSEPSLPVEDSQDLYNASPEPKVSYLCAGRSSQFQFSLEDDTQSQLLDADGFLNVGR 832

  Fly   999 --------TRRTASD--EEN-------ELLDLCSGQFPQTQMLSSDAPSVDTAVISQIPMTQFGG 1046
                    ..|.|.|  :||       ||||||||||..:...:|.|             |:...
 Frog   833 HQSKYSSAKHRLALDTMDENAMDANMDELLDLCSGQFKDSISGTSQA-------------TEKEA 884

  Fly  1047 SSQAADELEGLCSGTFATQLPSQAPTQQP----------EQQEESEVPAAVANRIVSSDEEAQED 1101
            ..|..|||..||||.|.:|  :...||..          |:::.|:|.|..::..::  |..||:
 Frog   885 KKQPMDELLELCSGKFVSQ--ADCSTQDSSASAKDSSANEKKDMSDVAALGSSSFLA--EREQEE 945

  Fly  1102 ALEVDKPRNKKLTKKRPKKKAKLGFSDDEDSDDEVEEFDEESDAEPVEEIPETFVDYDSEENEIV 1166
            ..|.:....|.|.           ...:.|:|:..||.:.|.|.|..|        |:.:|:||:
 Frog   946 GEEEEFGEFKLLP-----------CDSESDNDENNEEEEGEKDNEDNE--------YEEDEDEIL 991

  Fly  1167 VEMTKKDRKIRAANFVDKEAELSESEWGSADEDEKNMDEYDIELGDEDQFDRDKLRHELGQIHAR 1231
            .:..|  ||:|..:|::.|||||.|:.||.||.|.:.|||:.|..|||....::|:.::.:||.:
 Frog   992 QQQQK--RKLRLKDFMEDEAELSGSDVGSGDEYEGDDDEYEEEAIDEDLPSDEELQDQVNKIHMK 1054

  Fly  1232 KMMDQDIREVRKIKELLFEE---EEEGANRQRQFRWKNVEAGFSLDDNRTDNGEGNDGSGD---- 1289
            ..||:|.|::|..:|....:   ..:|..|.|:|||||::....||..|.|: |..|..|:
 Frog  1055 VTMDEDQRQLRLYQERYLADGDLHSDGPGRTRKFRWKNLDDASQLDMFRRDS-EVEDADGENEET 1118

  Fly  1290 EENEHLWRKIRYEREQLLLEKGLKPEVASPLSTSVINTSNN-------GNSPAIRRLNIISSKKT 1347
            |:.|..|||.|:||||.|.::            :.:...||       |......:|    :||.
 Frog  1119 EDTELKWRKQRFEREQWLRQQ------------TQVGRDNNEEEEEDIGEDSQFMKL----AKKV 1167

  Fly  1348 T-------VEVKKNSPFLISKTIAGKQQKSAVR---------GSFLIRDQQTLSKLAGLTKGTSG 1396
            |       |..:.|.|    |.:..|.|...:|         ||.|.:.::.|.|||.::
 Frog  1168 TAKALQKKVSTELNEP----KKLEAKNQYEVIRPFSHPKLRTGSLLSKPKEVLQKLAAVS----- 1223

  Fly  1397 DVDAAEGTISVKSAKAKNFVFATLTEEEHENRKRKAADILNSSTETGVNF-IKKPK 1451
            |::..      ....::||||.|::    ..:|.:..|...|.....::. :..||
 Frog  1224 DLNPN------APRNSRNFVFQTVS----PGKKEEPTDKPRSKVRKNISVAVPSPK 1269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Claspin	NP_728981.1	2A1904	<96..411	CDD:273344	53/315 (17%)
		DNA_pol_phi	<850..933	CDD:461488	30/128 (23%)
clspn	XP_002938885.3	None