DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL1B and PBY1

DIOPT Version :9

Sequence 1:	NP_729025.1	Gene:	TTLL1B / 326203	FlyBaseID:	FBgn0052238	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_009652.2	Gene:	PBY1 / 852391	SGDID:	S000000298	Length:	753	Species:	Saccharomyces cerevisiae

Alignment Length:	396	Identity:	83/396 - (20%)
Similarity:	147/396 - (37%)	Gaps:	97/396 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 YWAGVQTCRNIFSVDSG-------------YRMHDNQMINHFPNHY---------ELSRKDLLVK 150
            |...|:...|:...|:|             |...|...:...||:|         .|.||..|..
Yeast   357 YLPQVEIVSNLPEFDNGGCEKEMKVFHYGDYEQLDMDKLMELPNNYFTNSYIYRKALIRKHFLSH 421

  Fly   151 NIKRYRKDLERDGNPLAEKTESNNSSGTRYLYLDFVPTTFVLPADYNMFVE-------EYRKFPL 208
            .|:.|              |..|..|..:..||:    :|.:..||..|::       |.|: .|
Yeast   422 TIQTY--------------TAKNPESILKKAYLE----SFTIDLDYAEFLDDALDENWELRQ-EL 467

  Fly   209 ST------WIMKPCGKSQGAGIFLINKLSKLKKW-------------------SREAKGPF---- 244
            ..      ||:||....:|.||.:...:..|:..                   :.:..|.|
Yeast   468 ENESQDKWWIVKPSMSDKGQGIRVFKTIEDLQAIFDSFDDEDSEAEESGNDDDADDVNGEFMDNN 532

  Fly   245 HPQIAK-ESYVISRYIDNPLLIG---GKKFDLRLYVLVASFRPLKAYLFKQGFCRFCTV------ 299
            ...|:: ..::|..|:.||||:.   .:||.:|.||:...  .|:.:::.:....|...
Yeast   533 KVNISQLRHFIIQEYLTNPLLLASMDNRKFHIRCYVVCRG--DLQVFVYDRMLALFAAKPFVPLD 595

  Fly   300 KYDTSVTELDNMYVHLTNVSVQ--KHGGEYNTLHGGKWSVQNLALYLEGTRGKEVTDRLFGAISW 362
            .|..|||:|.::..||||..:|  |...:.:.|...  |::.    :...|...:.:::....:.
Yeast   596 PYAYSVTDLKDLECHLTNTCLQSKKKDKDSSVLEFD--SIEE----IPNERKSNIKEQIHSITND 654

  Fly   363 LIVHSLRAVAPVMASDRHCFECYGYDIIIDNALKPWLVEVNASPSLTSTTVNDRILKYKLIDNIL 427
            :.:.::...........:.||.||.|.:||:..:..|:|:||.|....|..:.:.|..:|.|:.:
Yeast   655 VFLAAVNVNRLNFQPLPNAFETYGVDFLIDSNYEVKLLEINAFPDFKQTGKDLKNLIDELFDDTV 719

  Fly   428 SVVLPP 433
            ...:.|
Yeast   720 KYCVTP 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1B	NP_729025.1	TTL	126..438	CDD:281171	77/365 (21%)
PBY1	NP_009652.2	surE	1..311	CDD:272899
PBY1	NP_009652.2	TTL	389..732	CDD:397308	77/364 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3002
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1567
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.790