DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL1B and TTLL2

DIOPT Version :9

Sequence 1:	NP_729025.1	Gene:	TTLL1B / 326203	FlyBaseID:	FBgn0052238	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_114155.4	Gene:	TTLL2 / 83887	HGNCID:	21211	Length:	592	Species:	Homo sapiens

Alignment Length:	373	Identity:	132/373 - (35%)
Similarity:	188/373 - (50%)	Gaps:	83/373 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 KSVLVNNFEKRGWH----QVNGDDDWHFYWAGVQTCRNIFSVDSGYRMHDN------QMINHFPN 138
            :|||:    :|||:    |....:||:.||.           .|.:||.::      |.:||.|.
Human   100 QSVLL----ERGWNKFDKQEQNAEDWNLYWR-----------TSSFRMTEHNSVKPWQQLNHHPG 149

  Fly   139 HYELSRKDLLVKNIKRYRKDLERDGNPLAEKTESNNSSGTRYLYLDFVPTTFVLPADYNMFVEEY 203
            ..:|:|||.|.|::|..|:                 ..||. || .|:|.|||:|.||..||.||
Human   150 TTKLTRKDCLAKHLKHMRR-----------------MYGTS-LY-QFIPLTFVMPNDYTKFVAEY 195

  Fly   204 --RKFPLST----WIMKPCGKSQGAGIFLINKLSKLKKWSREAKGPFHPQIAKESYVISRYIDNP 262
              .:..|.|    ||.||...|:|.||.:.:              .|...|..:.|::.:||.||
Human   196 FQERQMLGTKHSYWICKPAELSRGRGILIFS--------------DFKDFIFDDMYIVQKYISNP 246

  Fly   263 LLIGGKKFDLRLYVLVASFRPLKAYLFKQGFCRFCTVKYDTSVTELDNMYVHLTNVSVQKHGGEY 327
            ||||..|.|||:||.|..|:||..|::::|..||.|.|:|.|  .|.|.|.||||.|:.|.|..|
Human   247 LLIGRYKCDLRIYVCVTGFKPLTIYVYQEGLVRFATEKFDLS--NLQNNYAHLTNSSINKSGASY 309

  Fly   328 NTL-----HGGKWSVQNLALYLEGTRGKEVTDRLFGAISWLIVH-----SLRAVAPVMASDRHCF 382
            ..:     ||.||::.....||   |..:|.|.|.    |..:|     ::.|:||.:....:||
Human   310 EKIKEVIGHGCKWTLSRFFSYL---RSWDVDDLLL----WKKIHRMVILTILAIAPSVPFAANCF 367

  Fly   383 ECYGYDIIIDNALKPWLVEVNASPSLTSTTVNDRILKYKLIDNILSVV 430
            |.:|:||:||:.|||||:|||.||:||.....|.::|.||:.:|:.::
Human   368 ELFGFDILIDDNLKPWLLEVNYSPALTLDCSTDVLVKRKLVHDIIDLI 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1B	NP_729025.1	TTL	126..438	CDD:281171	120/327 (37%)
TTLL2	NP_114155.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..77
		TTL	140..412	CDD:281171	117/313 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001326
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810