DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL1B and ttll2

DIOPT Version :9

Sequence 1:	NP_729025.1	Gene:	TTLL1B / 326203	FlyBaseID:	FBgn0052238	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001104700.1	Gene:	ttll2 / 799958	ZFINID:	ZDB-GENE-041014-297	Length:	577	Species:	Danio rerio

Alignment Length:	484	Identity:	136/484 - (28%)
Similarity:	202/484 - (41%)	Gaps:	138/484 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 KRGW----HQVNGDDDWHFYWAGVQTCRNIFSVDSGYRMHDN------QMINHFPNHYELSRKDL 147
            :|||    .:|..:.||:.||.           .||:|..|.      |.:||.|....::|||.
Zfish    29 ERGWEEFDEEVQQEGDWNLYWR-----------TSGFRNSDYENILPWQRLNHHPKVTHVTRKDY 82

  Fly   148 LVKNIKRYRKDLERDGNPLAEKTESNNSSGTRYLYLDFVPTTFVLPADYNMFVEEYRKFPLST-W 211
            ||::::|.:...                ..|.|   .|.|:||:||.:|..|:..|.|...|. |
Zfish    83 LVRHLRRMKCAF----------------GATLY---GFSPSTFILPNEYTKFLGVYTKNHSSRYW 128

  Fly   212 IMKPCGKSQGAGIFLINKLSKLKKWSREAKGPFHPQIAKESYVISRYIDNPLLIGGKKFDLRLYV 276
            |.||...|:|.||||...:..|              :...|.::.|||.|||||.|.|||||:||
Zfish   129 ICKPVDLSRGRGIFLFEDIKDL--------------VYDSSVIVQRYISNPLLISGYKFDLRIYV 179

  Fly   277 LVASFRPLKAYLFKQGFCRFCTVKYDTSVTELDNMYVHLTNVSVQKHGGEY-----NTLHGGKWS 336
            .|.||.||..|:.::|..||.|.||  ::..|.|:|.||||.|:.:.|..|     ....|.||:
Zfish   180 CVKSFSPLVIYMHQEGLVRFATEKY--TLASLHNLYSHLTNTSINRFGLCYAMDKERVGKGCKWT 242

  Fly   337 VQNLALYLEGTRGKEVTDRLFGAISWLIVHSLRAVAPVMASDRHCFECYGYDIIIDNALKPWLVE 401
            :.....:|......|:.  |:..||.::..:|....|.:.|..:|.|..|:||:||::.||||:|
Zfish   243 LSQFRCFLHKQDVNELL--LWHKISNIVTLTLLKAVPCIPSSPNCLELLGFDILIDSSYKPWLLE 305

  Fly   402 VNASPSLTSTTVND------------RILKYKLIDN---------------------------IL 427
            ||.||:|:.....|            .:|.|:.||:                           :|
Zfish   306 VNHSPALSVDCAADVTVKKGLIGDFIDLLNYRTIDSFRQKGHLRKKYTRSGSKDLQPKVFQGILL 370

  Fly   428 SVVLPPDGVPDVRWNKVPSADALG--------------------------------NFELLIDEE 460
            |..|....:....|.: |.:.:||                                :.|.:|..|
Zfish   371 SKTLHATPIRKRSWTR-PISTSLGSRDIGLCSVNASARNSTVYANRPVSKSKSYDKSTEKVIAVE 434

  Fly   461 LAAQD--EQHQNSSSNTHSKTSKMGSRWK 487
            :.:.|  .:.:||:.||.|...|:.|.::
Zfish   435 VESDDLNLRPKNSTRNTPSSVCKLPSLYE 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1B	NP_729025.1	TTL	126..438	CDD:281171	111/362 (31%)
ttll2	NP_001104700.1	TTL	64..344	CDD:281171	106/316 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001326
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810