DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL1B and ttll1

DIOPT Version :9

Sequence 1:	NP_729025.1	Gene:	TTLL1B / 326203	FlyBaseID:	FBgn0052238	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001307448.1	Gene:	ttll1 / 393994	ZFINID:	ZDB-GENE-040426-1326	Length:	423	Species:	Danio rerio

Alignment Length:	425	Identity:	265/425 - (62%)
Similarity:	335/425 - (78%)	Gaps:	17/425 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KIGFCTDLDKSVLVNNFEKRGWHQVNGDDDWHFYWAGVQTCRNIFSVDSGYRMHDNQMINHFPNH 139
            |:.:.||::||||:||||||||.||...:||:|||..:||.|.:||||:|||:.|:||:||||||
Zfish     4 KVKWVTDIEKSVLINNFEKRGWIQVTDSEDWNFYWMSIQTIRTVFSVDTGYRLTDDQMVNHFPNH 68

  Fly   140 YELSRKDLLVKNIKRYRKDLERDGNPLAEKTESNNSSGTRYLYLDFVPTTFVLPADYNMFVEEYR 204
            |||:||||::|||||||::||::.:.||||.:|.     :|:||||||.||:||||||:||||:|
Zfish    69 YELTRKDLMIKNIKRYRRELEKENSALAEKDDSG-----KYIYLDFVPVTFMLPADYNLFVEEFR 128

  Fly   205 KFPLSTWIMKPCGKSQGAGIFLINKLSKLKKWSREAKGP--FHPQIAKESYVISRYIDNPLLIGG 267
            |.|.||||||||||:||.|||||||||::|||||:::..  ......||:||||.||||||||||
Zfish   129 KSPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSRTSTFVAANSGKEAYVISLYIDNPLLIGG 193

  Fly   268 KKFDLRLYVLVASFRPLKAYLFKQGFCRFCTVKYDTSVTELDNMYVHLTNVSVQKHGGEYNTLHG 332
            |||||||||||.::||||.|::|.||||||||||..|.:|||||:||||||::||||.:||.:||
Zfish   194 KKFDLRLYVLVTTYRPLKCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGDDYNHVHG 258

  Fly   333 GKWSVQNLALYLEGTRGKEVTDRLFGAISWLIVHSLRAVAPVMASDRHCFECYGYDIIIDNALKP 397
            |||:|.||.||||.|||.:||:.||..|.|:||.||:||||||.:|:|||||||||||||:.|||
Zfish   259 GKWTVSNLRLYLESTRGPDVTNHLFDQIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDRLKP 323

  Fly   398 WLVEVNASPSLTSTTVNDRILKYKLIDNILSVVLPPDGVPDVRWNKVPSADALGNFELLIDEELA 462
            ||:||||||||||:|.|||||||.||::.|::|.|...:||.|||:....:|||::::|.|||.|
Zfish   324 WLIEVNASPSLTSSTANDRILKYNLINDTLNIVTPNAEIPDCRWNRSLPKEALGHYQVLYDEEQA 388

  Fly   463 AQDEQHQNSSSNT-HS----KTSKMGSR-----WK 487
            ..:...::..|.: ||    .|.:.|.|     ||
Zfish   389 LSESTERDLRSRSGHSLGSKSTRQSGVRPFPATWK 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1B	NP_729025.1	TTL	126..438	CDD:281171	213/313 (68%)
ttll1	NP_001307448.1	TTL	59..365	CDD:281171	212/310 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573449
Domainoid	1	1.000	453	1.000	Domainoid score	I484
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8174
Inparanoid	1	1.050	563	1.000	Inparanoid score	I1049
OMA	1	1.010	-	-		QHG57390
OrthoDB	1	1.010	-	-		D315374at33208
OrthoFinder	1	1.000	-	-		FOG0001326
OrthoInspector	1	1.000	-	-		oto38610
orthoMCL	1	0.900	-	-		OOG6_104876
Panther	1	1.100	-	-	LDO	PTHR12241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4704
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870