DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL1B and Ttll9

DIOPT Version :9

Sequence 1:	NP_729025.1	Gene:	TTLL1B / 326203	FlyBaseID:	FBgn0052238	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001014073.1	Gene:	Ttll9 / 311548	RGDID:	1359622	Length:	461	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	176/454 - (38%)
Similarity:	254/454 - (55%)	Gaps:	57/454 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 SGANSGGGASGGAQGHDKLKIGFCTDLDKSVLVNNFEKRGWHQVNGDDDWHFYWAGVQTCRNIFS 120
            |..:.|.|||.|.:...:..|.|.|.|..:::.....:.||.:|..:.:|.|||..|...|..|
  Rat     6 SQTSKGHGASKGKEREQRTLIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENF- 69

  Fly   121 VDSGYRMHDNQMINHFPNHYELSRKDLLVKNIKRYRKDLERDGNPLAEKTESNNSSGTRYLYLDF 185
             |..| |.::..|:||.|||||:||:.:|||:||:||.|||:    |.|||:..        .||
  Rat    70 -DHTY-MDEHVRISHFRNHYELTRKNYMVKNLKRFRKQLERE----AGKTEAAK--------CDF 120

  Fly   186 VPTTFVLPADYNMFVEEYRKFPLSTWIMKPCGKSQGAGIFLINKLSKLKKWSREAKGP------- 243
            .|.||.:|.:|::||||:||.|..||||||..:|||.||||..:|..:..|.:...|.
  Rat   121 FPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIMDWRKGTAGKKVTSVET 185

  Fly   244 ------FHP--------------QIAKESYVISRYIDNPLLIGGKKFDLRLYVLVASFRPLKAYL 288
                  .:|              .|..|:||..||::||.||||:|||||:||||.|:.||:|:|
  Rat   186 QATRANVNPSGSHDTRSSDDQKDDIPVENYVAQRYVENPYLIGGRKFDLRVYVLVMSYIPLRAWL 250

  Fly   289 FKQGFCRFCTVKYDTSVTELDNMYVHLTNVSVQKHGGEYNTLHGGKWSVQNLALYLEGTRGKEVT 353
            ::.||.||...::  ::..:|:.|||||||:|||...:|:...|.||::|....||....|.:..
  Rat   251 YRDGFARFSNTRF--TLNSIDDHYVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPKAV 313

  Fly   354 DRLFGAISWLIVHSLRAVAPVMASDRHCFECYGYDIIIDNALKPWLVEVNASPSLTSTTVNDRIL 418
            :.||..:..:.:.||::|..|:.||:||||.|||||:||..|||||:|||||||||:::..|..|
  Rat   314 ETLFSDMDNIFIKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYEL 378

  Fly   419 KYKLIDNILSVVLPPDGVPDVRWNKVPSADALGNFELLIDEELAAQDE------QHQNSSSNTH 476
            |..|:::.|.||       |:..........:|.|:|:.::...:::|      ...|..:|||
  Rat   379 KTCLLEDTLHVV-------DMEARLTGKEKRVGGFDLMWNDGPVSREEGPCDLSGMGNFVTNTH 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1B	NP_729025.1	TTL	126..438	CDD:281171	145/338 (43%)
Ttll9	NP_001014073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		6/13 (46%)
		TTL	74..390	CDD:281171	143/329 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..208		1/21 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D315374at33208
OrthoFinder	1	1.000	-	-		FOG0001326
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820