DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL1B and TTLL1

DIOPT Version :9

Sequence 1:	NP_729025.1	Gene:	TTLL1B / 326203	FlyBaseID:	FBgn0052238	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_036395.1	Gene:	TTLL1 / 25809	HGNCID:	1312	Length:	423	Species:	Homo sapiens

Alignment Length:	425	Identity:	272/425 - (64%)
Similarity:	340/425 - (80%)	Gaps:	17/425 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KIGFCTDLDKSVLVNNFEKRGWHQVNGDDDWHFYWAGVQTCRNIFSVDSGYRMHDNQMINHFPNH 139
            |:.:.||::||||:||||||||.||..::||:|||..|||.||:|||::|||:.|:|::||||||
Human     4 KVKWVTDIEKSVLINNFEKRGWVQVTENEDWNFYWMSVQTIRNVFSVEAGYRLSDDQIVNHFPNH 68

  Fly   140 YELSRKDLLVKNIKRYRKDLERDGNPLAEKTESNNSSGTRYLYLDFVPTTFVLPADYNMFVEEYR 204
            |||:||||:|||||||||:||::|:|||||.|:.     :||||||||.|::||||||:||||:|
Human    69 YELTRKDLMVKNIKRYRKELEKEGSPLAEKDENG-----KYLYLDFVPVTYMLPADYNLFVEEFR 128

  Fly   205 KFPLSTWIMKPCGKSQGAGIFLINKLSKLKKWSREAK-GPFHPQIAKESYVISRYIDNPLLIGGK 268
            |.|.||||||||||:||.|||||||||::|||||::| ..|..|..||:||||.||:|||||||:
Human   129 KSPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSKTSSFVSQSNKEAYVISLYINNPLLIGGR 193

  Fly   269 KFDLRLYVLVASFRPLKAYLFKQGFCRFCTVKYDTSVTELDNMYVHLTNVSVQKHGGEYNTLHGG 333
            ||||||||||:::|||:.|::|.||||||||||..|.:|||||:||||||::||||.:||.:|||
Human   194 KFDLRLYVLVSTYRPLRCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGEDYNHIHGG 258

  Fly   334 KWSVQNLALYLEGTRGKEVTDRLFGAISWLIVHSLRAVAPVMASDRHCFECYGYDIIIDNALKPW 398
            ||:|.||.||||.|||||||.:||..|.|:||.||:||||||.:|:|||||||||||||:.||||
Human   259 KWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKPW 323

  Fly   399 LVEVNASPSLTSTTVNDRILKYKLIDNILSVVLPPDGVPDVRWNKVPSADALGNFELLIDEELAA 463
            |:||||||||||:|.|||||||.||::.|::.:|...:||.:|||.|..:.|||:|:|.|||||.
Human   324 LIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQ 388

  Fly   464 QD------EQHQNSSSNTHSKTSKMGSR-----WK 487
            .|      ...|..|....:..|:...|     ||
Human   389 GDGADRELRSRQGQSLGPRAGRSRDSGRAVLTTWK 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1B	NP_729025.1	TTL	126..438	CDD:281171	217/312 (70%)
TTLL1	NP_036395.1	TTL	59..364	CDD:397308	216/309 (70%)
TTLL1	NP_036395.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..423		4/31 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140736
Domainoid	1	1.000	463	1.000	Domainoid score	I474
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8174
Inparanoid	1	1.050	581	1.000	Inparanoid score	I1022
Isobase	1	0.950	-	0	Normalized mean entropy	S3002
OMA	1	1.010	-	-		QHG57390
OrthoDB	1	1.010	-	-		D315374at33208
OrthoFinder	1	1.000	-	-		FOG0001326
OrthoInspector	1	1.000	-	-		oto90115
orthoMCL	1	0.900	-	-		OOG6_104876
Panther	1	1.100	-	-	LDO	PTHR12241
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1567
SonicParanoid	1	1.000	-	-		X4704
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	18	17.750