DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TTLL1B and TTLL9

DIOPT Version :9

Sequence 1:	NP_729025.1	Gene:	TTLL1B / 326203	FlyBaseID:	FBgn0052238	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001008409.1	Gene:	TTLL9 / 164395	HGNCID:	16118	Length:	439	Species:	Homo sapiens

Alignment Length:	446	Identity:	172/446 - (38%)
Similarity:	241/446 - (54%)	Gaps:	52/446 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GRTSVGANQSVTNGNSNSGANSGGGASGGAQGHDKLKIGFCTDLDKSVLVNNFEKRGWHQVNGDD 103
            |.|::...:.:.|.|     ..|.|.|.|.:...:..|.|.|.|..:::.....:.||.:|..:.
Human    12 GTTAIRCPKKLQNQN-----YKGHGLSKGKEREQRASIRFKTTLMNTLMDVLRHRPGWVEVKDEG 71

  Fly   104 DWHFYWAGVQTCRNIFSVDSGYRMHDNQMINHFPNHYELSRKDLLVKNIKRYRKDLERDGNPLAE 168
            :|.|||..|...|..|  |..| |.::..|:||.|||||:||:.:|||:||:||.|||:    |.
Human    72 EWDFYWCDVSWLRENF--DHTY-MDEHVRISHFRNHYELTRKNYMVKNLKRFRKQLERE----AG 129

  Fly   169 KTESNNSSGTRYLYLDFVPTTFVLPADYNMFVEEYRKFPLSTWIMKPCGKSQGAGIFLINKLSKL 233
            |.|:..        .||.|.||.:|.:|::||||:||.|..||||||..:|||.||||..:|..:
Human   130 KLEAAK--------CDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDI 186

  Fly   234 KKWSREAKGPFHPQ--IAKESYVISRYIDNPLLIGGKKFDLRLYVLVASFRPLKAYLFKQGFCRF 296
            ..|.::.:.....:  |..|:||..|||:||.||||:|||||:||||.|.  ....|...|..|
Human   187 VDWRKDTRSSDDQKDDIPVENYVAQRYIENPYLIGGRKFDLRVYVLVMSV--FAECLLWSGHRR- 248

  Fly   297 CTVKYDTSVTELDNMYVHLTNVSVQKHGGEYNTLHGGKWSVQNLALYLEGTRGKEVTDRLFGAIS 361
                          ..||||||:|||...:|:...|.||::|....||....|.|..:.||..|.
Human   249 --------------QDVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVETLFRDID 299

  Fly   362 WLIVHSLRAVAPVMASDRHCFECYGYDIIIDNALKPWLVEVNASPSLTSTTVNDRILKYKLIDNI 426
            .:.|.||::|..|:.||:||||.|||||:||..|||||:|||||||||:::..|..||..|:::.
Human   300 NIFVKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDT 364

  Fly   427 LSVVLPPDGVPDVRWNKVPSADALGNFELLIDEELAAQDEQHQNSS------SNTH 476
            |.||       |:..........:|.|:|:.::...:::|...:.|      :|||
Human   365 LHVV-------DMEARLTGREKRVGGFDLMWNDGPVSREEGAPDLSGMGNFVTNTH 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL1B	NP_729025.1	TTL	126..438	CDD:281171	139/313 (44%)
TTLL9	NP_001008409.1	TTL	92..368	CDD:281171	137/304 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2157
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D315374at33208
OrthoFinder	1	1.000	-	-		FOG0001326
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1567
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850